Identification of plasma biomarker candidates in glioblastoma using an antibody-array-based proteomic approach
Background. Glioblastoma multiforme (GBM) is a brain tumour with a very high patient mortality rate, with a median survival of 47 weeks. This might be improved by the identification of novel diagnostic, prognostic and predictive therapy-response biomarkers, preferentially through the monitoring of t...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Sciendo
2014-09-01
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| Series: | Radiology and Oncology |
| Subjects: | |
| Online Access: | https://doi.org/10.2478/raon-2014-0014 |
| _version_ | 1818691688602796032 |
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| author | Zupancic Klemen Blejec Andrej Herman Ana Veber Matija Verbovsek Urska Korsic Marjan Knezevic Miomir Rozman Primoz Turnsek Tamara Lah Gruden Kristina Motaln Helena |
| author_facet | Zupancic Klemen Blejec Andrej Herman Ana Veber Matija Verbovsek Urska Korsic Marjan Knezevic Miomir Rozman Primoz Turnsek Tamara Lah Gruden Kristina Motaln Helena |
| author_sort | Zupancic Klemen |
| collection | DOAJ |
| description | Background. Glioblastoma multiforme (GBM) is a brain tumour with a very high patient mortality rate, with a median survival of 47 weeks. This might be improved by the identification of novel diagnostic, prognostic and predictive therapy-response biomarkers, preferentially through the monitoring of the patient blood. The aim of this study was to define the impact of GBM in terms of alterations of the plasma protein levels in these patients. Materials and methods. We used a commercially available antibody array that includes 656 antibodies to analyse blood plasma samples from 17 healthy volunteers in comparison with 17 blood plasma samples from patients with GBM. |
| first_indexed | 2024-12-17T12:45:52Z |
| format | Article |
| id | doaj.art-81c5d86e53c34f9d9137272d98c392f4 |
| institution | Directory Open Access Journal |
| issn | 1581-3207 |
| language | English |
| last_indexed | 2024-12-17T12:45:52Z |
| publishDate | 2014-09-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Radiology and Oncology |
| spelling | doaj.art-81c5d86e53c34f9d9137272d98c392f42022-12-21T21:47:44ZengSciendoRadiology and Oncology1581-32072014-09-0148325726610.2478/raon-2014-0014raon-2014-0014Identification of plasma biomarker candidates in glioblastoma using an antibody-array-based proteomic approachZupancic Klemen0Blejec Andrej1Herman Ana2Veber Matija3Verbovsek Urska4Korsic Marjan5Knezevic Miomir6Rozman Primoz7Turnsek Tamara Lah8Gruden Kristina9Motaln Helena10Department of Biotechnology and Systems Biology, National Institute of Biology, Ljubljana, SloveniaDepartment of Entomology, National Institute of Biology, Ljubljana, SloveniaBlood Transfusion Centre, Immunohaematology Department Ljubljana, SloveniaEducell Ltd., Trzin, SloveniaDepartment of Genetic Toxicology and Cancer Biology, National Institute of Biology, Ljubljana, SloveniaDepartment of Neurosurgery, University Medical Centre Ljubljana, University of Ljubljana, Ljubljana, SloveniaEducell Ltd., Trzin, SloveniaBlood Transfusion Centre, Immunohaematology Department Ljubljana, SloveniaDepartment of Genetic Toxicology and Cancer Biology, National Institute of Biology, Ljubljana, SloveniaDepartment of Biotechnology and Systems Biology, National Institute of Biology, Ljubljana, SloveniaDepartment of Genetic Toxicology and Cancer Biology, National Institute of Biology, Ljubljana, SloveniaBackground. Glioblastoma multiforme (GBM) is a brain tumour with a very high patient mortality rate, with a median survival of 47 weeks. This might be improved by the identification of novel diagnostic, prognostic and predictive therapy-response biomarkers, preferentially through the monitoring of the patient blood. The aim of this study was to define the impact of GBM in terms of alterations of the plasma protein levels in these patients. Materials and methods. We used a commercially available antibody array that includes 656 antibodies to analyse blood plasma samples from 17 healthy volunteers in comparison with 17 blood plasma samples from patients with GBM.https://doi.org/10.2478/raon-2014-0014glioblastomaproteomicsbiomarkerantibody arrayplasma |
| spellingShingle | Zupancic Klemen Blejec Andrej Herman Ana Veber Matija Verbovsek Urska Korsic Marjan Knezevic Miomir Rozman Primoz Turnsek Tamara Lah Gruden Kristina Motaln Helena Identification of plasma biomarker candidates in glioblastoma using an antibody-array-based proteomic approach Radiology and Oncology glioblastoma proteomics biomarker antibody array plasma |
| title | Identification of plasma biomarker candidates in glioblastoma using an antibody-array-based proteomic approach |
| title_full | Identification of plasma biomarker candidates in glioblastoma using an antibody-array-based proteomic approach |
| title_fullStr | Identification of plasma biomarker candidates in glioblastoma using an antibody-array-based proteomic approach |
| title_full_unstemmed | Identification of plasma biomarker candidates in glioblastoma using an antibody-array-based proteomic approach |
| title_short | Identification of plasma biomarker candidates in glioblastoma using an antibody-array-based proteomic approach |
| title_sort | identification of plasma biomarker candidates in glioblastoma using an antibody array based proteomic approach |
| topic | glioblastoma proteomics biomarker antibody array plasma |
| url | https://doi.org/10.2478/raon-2014-0014 |
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