miR-184 represses β-catenin and behaves as a skin tumor suppressor
Abstract miR-184-knockout mice display perturbed epidermal stem cell differentiation. However, the potential role of miR-184 in skin pathology is unclear. Here, we report that miR-184 controls epidermal stem cell dynamics and that miR-184 ablation enhances skin carcinogenesis in mice. In agreement,...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2024-02-01
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| Series: | Cell Death and Disease |
| Online Access: | https://doi.org/10.1038/s41419-024-06554-4 |
| _version_ | 1797273042877939712 |
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| author | Lubov Turovsky Ghazal Kheshaiboun Gharam Yassen Sara Nagosa Ilanit Boyango Aya Amitai-Lange Swarnabh Bhattacharya Neta Ilan Israel Vlodavsky Daniel Aberdam Ruby Shalom-Feuerstein Emily Avitan-Hersh |
| author_facet | Lubov Turovsky Ghazal Kheshaiboun Gharam Yassen Sara Nagosa Ilanit Boyango Aya Amitai-Lange Swarnabh Bhattacharya Neta Ilan Israel Vlodavsky Daniel Aberdam Ruby Shalom-Feuerstein Emily Avitan-Hersh |
| author_sort | Lubov Turovsky |
| collection | DOAJ |
| description | Abstract miR-184-knockout mice display perturbed epidermal stem cell differentiation. However, the potential role of miR-184 in skin pathology is unclear. Here, we report that miR-184 controls epidermal stem cell dynamics and that miR-184 ablation enhances skin carcinogenesis in mice. In agreement, repression of miR-184 in human squamous cell carcinoma (SCC) enhances neoplastic hallmarks of human SCC cells in vitro and tumor development in vivo. Characterization of miR-184-regulatory network, suggests that miR-184 inhibits pro-oncogenic pathways, cell proliferation, and epithelial to mesenchymal transformation. Of note, depletion of miR-184 enhances the levels of β-catenin under homeostasis and following experimental skin carcinogenesis. Finally, the repression of β-catenin by miR-184, inhibits the neoplastic phenotype of SCC cells. Taken together, miR-184 behaves as an epidermal tumor suppressor, and may provide a potentially useful target for skin SCC therapy. |
| first_indexed | 2024-03-07T14:37:53Z |
| format | Article |
| id | doaj.art-81c6513c80504b699b3cd22ba2134fe7 |
| institution | Directory Open Access Journal |
| issn | 2041-4889 |
| language | English |
| last_indexed | 2024-03-07T14:37:53Z |
| publishDate | 2024-02-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Cell Death and Disease |
| spelling | doaj.art-81c6513c80504b699b3cd22ba2134fe72024-03-05T20:31:25ZengNature Publishing GroupCell Death and Disease2041-48892024-02-0115211010.1038/s41419-024-06554-4miR-184 represses β-catenin and behaves as a skin tumor suppressorLubov Turovsky0Ghazal Kheshaiboun1Gharam Yassen2Sara Nagosa3Ilanit Boyango4Aya Amitai-Lange5Swarnabh Bhattacharya6Neta Ilan7Israel Vlodavsky8Daniel Aberdam9Ruby Shalom-Feuerstein10Emily Avitan-Hersh11Department of Genetics & Developmental Biology, The Rappaport Faculty of Medicine & Research Institute, Technion Integrated Cancer Center, Technion – Israel Institute of TechnologyDepartment of Genetics & Developmental Biology, The Rappaport Faculty of Medicine & Research Institute, Technion Integrated Cancer Center, Technion – Israel Institute of TechnologyDepartment of Genetics & Developmental Biology, The Rappaport Faculty of Medicine & Research Institute, Technion Integrated Cancer Center, Technion – Israel Institute of TechnologyDepartment of Genetics & Developmental Biology, The Rappaport Faculty of Medicine & Research Institute, Technion Integrated Cancer Center, Technion – Israel Institute of TechnologySkin Cancer Research lab, Clinical research institute (CRIR), Rambam Health Care CampusDepartment of Genetics & Developmental Biology, The Rappaport Faculty of Medicine & Research Institute, Technion Integrated Cancer Center, Technion – Israel Institute of TechnologyDepartment of Genetics & Developmental Biology, The Rappaport Faculty of Medicine & Research Institute, Technion Integrated Cancer Center, Technion – Israel Institute of TechnologyCell Biology and Cancer Science, The Ruth and Bruce Rappaport Faculty of Medicine, Technion Integrated Cancer Center, Technion Israel Institute of TechnologyCell Biology and Cancer Science, The Ruth and Bruce Rappaport Faculty of Medicine, Technion Integrated Cancer Center, Technion Israel Institute of TechnologyUniversité de Paris Cité, INSERM U1138, Centre des CordeliersDepartment of Genetics & Developmental Biology, The Rappaport Faculty of Medicine & Research Institute, Technion Integrated Cancer Center, Technion – Israel Institute of TechnologySkin Cancer Research lab, Clinical research institute (CRIR), Rambam Health Care CampusAbstract miR-184-knockout mice display perturbed epidermal stem cell differentiation. However, the potential role of miR-184 in skin pathology is unclear. Here, we report that miR-184 controls epidermal stem cell dynamics and that miR-184 ablation enhances skin carcinogenesis in mice. In agreement, repression of miR-184 in human squamous cell carcinoma (SCC) enhances neoplastic hallmarks of human SCC cells in vitro and tumor development in vivo. Characterization of miR-184-regulatory network, suggests that miR-184 inhibits pro-oncogenic pathways, cell proliferation, and epithelial to mesenchymal transformation. Of note, depletion of miR-184 enhances the levels of β-catenin under homeostasis and following experimental skin carcinogenesis. Finally, the repression of β-catenin by miR-184, inhibits the neoplastic phenotype of SCC cells. Taken together, miR-184 behaves as an epidermal tumor suppressor, and may provide a potentially useful target for skin SCC therapy.https://doi.org/10.1038/s41419-024-06554-4 |
| spellingShingle | Lubov Turovsky Ghazal Kheshaiboun Gharam Yassen Sara Nagosa Ilanit Boyango Aya Amitai-Lange Swarnabh Bhattacharya Neta Ilan Israel Vlodavsky Daniel Aberdam Ruby Shalom-Feuerstein Emily Avitan-Hersh miR-184 represses β-catenin and behaves as a skin tumor suppressor Cell Death and Disease |
| title | miR-184 represses β-catenin and behaves as a skin tumor suppressor |
| title_full | miR-184 represses β-catenin and behaves as a skin tumor suppressor |
| title_fullStr | miR-184 represses β-catenin and behaves as a skin tumor suppressor |
| title_full_unstemmed | miR-184 represses β-catenin and behaves as a skin tumor suppressor |
| title_short | miR-184 represses β-catenin and behaves as a skin tumor suppressor |
| title_sort | mir 184 represses β catenin and behaves as a skin tumor suppressor |
| url | https://doi.org/10.1038/s41419-024-06554-4 |
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