Quantitative expression data of human estrogen receptor α variants in non-functioning pituitary adenomas obtained by reverse transcription-digital polymerase chain reaction analysis
Expression profiles of gonadal steroid receptor variants have been reportedly associated with malignancy in breast and prostate cancers [1,2]. However, such associations with pituitary tumors remain unclear. Therefore, the expression levels of the wild-type ESR1 (ERα66) and the ESR1 variants (ERαi34...
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| Format: | Article |
| Language: | English |
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Elsevier
2020-12-01
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| Series: | Data in Brief |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352340920313342 |
| _version_ | 1819295858829557760 |
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| author | Yujiro Hattori Hirotaka Ishii Shigeyuki Tahara Akio Morita Hitoshi Ozawa |
| author_facet | Yujiro Hattori Hirotaka Ishii Shigeyuki Tahara Akio Morita Hitoshi Ozawa |
| author_sort | Yujiro Hattori |
| collection | DOAJ |
| description | Expression profiles of gonadal steroid receptor variants have been reportedly associated with malignancy in breast and prostate cancers [1,2]. However, such associations with pituitary tumors remain unclear. Therefore, the expression levels of the wild-type ESR1 (ERα66) and the ESR1 variants (ERαi34, ERαi45c, and ERαΔ5) transcripts encoding constitutively active ERα proteins with C-terminal truncation in non-functioning pituitary adenomas (NFPAs) were evaluated using reverse transcription-digital polymerase chain reaction. The results revealed that the expression levels of the variants were approximately two orders of magnitude lower than that of ERα66 in NFPAs. These data were based on our previous article entitled “Accurate assessment of estrogen receptor profiles in non-functioning pituitary adenomas using RT-digital PCR and immunohistochemistry” [3]. |
| first_indexed | 2024-12-24T04:48:54Z |
| format | Article |
| id | doaj.art-81c6dd6b8024415b94de0dbc0eaf8159 |
| institution | Directory Open Access Journal |
| issn | 2352-3409 |
| language | English |
| last_indexed | 2024-12-24T04:48:54Z |
| publishDate | 2020-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Data in Brief |
| spelling | doaj.art-81c6dd6b8024415b94de0dbc0eaf81592022-12-21T17:14:36ZengElsevierData in Brief2352-34092020-12-0133106452Quantitative expression data of human estrogen receptor α variants in non-functioning pituitary adenomas obtained by reverse transcription-digital polymerase chain reaction analysisYujiro Hattori0Hirotaka Ishii1Shigeyuki Tahara2Akio Morita3Hitoshi Ozawa4Department of Anatomy and Neurobiology, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan; Department of Neurological Surgery, Nippon Medical School, Tokyo, Japan; Corresponding author.Department of Anatomy and Neurobiology, Graduate School of Medicine, Nippon Medical School, Tokyo, JapanDepartment of Neurological Surgery, Nippon Medical School, Tokyo, JapanDepartment of Neurological Surgery, Nippon Medical School, Tokyo, JapanDepartment of Anatomy and Neurobiology, Graduate School of Medicine, Nippon Medical School, Tokyo, JapanExpression profiles of gonadal steroid receptor variants have been reportedly associated with malignancy in breast and prostate cancers [1,2]. However, such associations with pituitary tumors remain unclear. Therefore, the expression levels of the wild-type ESR1 (ERα66) and the ESR1 variants (ERαi34, ERαi45c, and ERαΔ5) transcripts encoding constitutively active ERα proteins with C-terminal truncation in non-functioning pituitary adenomas (NFPAs) were evaluated using reverse transcription-digital polymerase chain reaction. The results revealed that the expression levels of the variants were approximately two orders of magnitude lower than that of ERα66 in NFPAs. These data were based on our previous article entitled “Accurate assessment of estrogen receptor profiles in non-functioning pituitary adenomas using RT-digital PCR and immunohistochemistry” [3].http://www.sciencedirect.com/science/article/pii/S2352340920313342non-functioning pituitary adenomasESR1estrogen receptor α variantRT-dPCR |
| spellingShingle | Yujiro Hattori Hirotaka Ishii Shigeyuki Tahara Akio Morita Hitoshi Ozawa Quantitative expression data of human estrogen receptor α variants in non-functioning pituitary adenomas obtained by reverse transcription-digital polymerase chain reaction analysis Data in Brief non-functioning pituitary adenomas ESR1 estrogen receptor α variant RT-dPCR |
| title | Quantitative expression data of human estrogen receptor α variants in non-functioning pituitary adenomas obtained by reverse transcription-digital polymerase chain reaction analysis |
| title_full | Quantitative expression data of human estrogen receptor α variants in non-functioning pituitary adenomas obtained by reverse transcription-digital polymerase chain reaction analysis |
| title_fullStr | Quantitative expression data of human estrogen receptor α variants in non-functioning pituitary adenomas obtained by reverse transcription-digital polymerase chain reaction analysis |
| title_full_unstemmed | Quantitative expression data of human estrogen receptor α variants in non-functioning pituitary adenomas obtained by reverse transcription-digital polymerase chain reaction analysis |
| title_short | Quantitative expression data of human estrogen receptor α variants in non-functioning pituitary adenomas obtained by reverse transcription-digital polymerase chain reaction analysis |
| title_sort | quantitative expression data of human estrogen receptor α variants in non functioning pituitary adenomas obtained by reverse transcription digital polymerase chain reaction analysis |
| topic | non-functioning pituitary adenomas ESR1 estrogen receptor α variant RT-dPCR |
| url | http://www.sciencedirect.com/science/article/pii/S2352340920313342 |
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