Simulation and experimental verification of ambient neutron doses in a pencil beam scanning proton therapy room as a function of treatment plan parameters
Out-of-field patient doses in proton therapy are dominated by neutrons. Currently, they are not taken into account by treatment planning systems. There is an increasing need to include out-of-field doses in the dose calculation, especially when treating children, pregnant patients, and patients with...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.903537/full |
| _version_ | 1828408231448281088 |
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| author | Olivier Van Hoey Liliana Stolarczyk Liliana Stolarczyk Liliana Stolarczyk Jan Lillhök Linda Eliasson Natalia Mojzeszek Malgorzata Liszka Malgorzata Liszka Ali Alkhiat Ali Alkhiat Vladimir Mares François Trompier Sebastian Trinkl Sebastian Trinkl Immaculada Martínez-Rovira Maite Romero-Expósito Carles Domingo Ondrej Ploc Roger Harrison Pawel Olko |
| author_facet | Olivier Van Hoey Liliana Stolarczyk Liliana Stolarczyk Liliana Stolarczyk Jan Lillhök Linda Eliasson Natalia Mojzeszek Malgorzata Liszka Malgorzata Liszka Ali Alkhiat Ali Alkhiat Vladimir Mares François Trompier Sebastian Trinkl Sebastian Trinkl Immaculada Martínez-Rovira Maite Romero-Expósito Carles Domingo Ondrej Ploc Roger Harrison Pawel Olko |
| author_sort | Olivier Van Hoey |
| collection | DOAJ |
| description | Out-of-field patient doses in proton therapy are dominated by neutrons. Currently, they are not taken into account by treatment planning systems. There is an increasing need to include out-of-field doses in the dose calculation, especially when treating children, pregnant patients, and patients with implants. In response to this demand, this work presents the first steps towards a tool for the prediction of out-of-field neutron doses in pencil beam scanning proton therapy facilities. As a first step, a general Monte Carlo radiation transport model for simulation of out-of-field neutron doses was set up and successfully verified by comparison of simulated and measured ambient neutron dose equivalent and neutron fluence energy spectra around a solid water phantom irradiated with a variation of different treatment plan parameters. Simulations with the verified model enabled a detailed study of the variation of the neutron ambient dose equivalent with field size, range, modulation width, use of a range shifter, and position inside the treatment room. For future work, it is planned to use this verified model to simulate out-of-field neutron doses inside the phantom and to verify the simulation results by comparison with previous in-phantom measurement campaigns. Eventually, these verified simulations will be used to build a library and a corresponding tool to allow assessment of out-of-field neutron doses at pencil beam scanning proton therapy facilities. |
| first_indexed | 2024-12-10T11:35:48Z |
| format | Article |
| id | doaj.art-81c8fe33ac2747abbdb89695469f8f33 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-10T11:35:48Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-81c8fe33ac2747abbdb89695469f8f332022-12-22T01:50:25ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-09-011210.3389/fonc.2022.903537903537Simulation and experimental verification of ambient neutron doses in a pencil beam scanning proton therapy room as a function of treatment plan parametersOlivier Van Hoey0Liliana Stolarczyk1Liliana Stolarczyk2Liliana Stolarczyk3Jan Lillhök4Linda Eliasson5Natalia Mojzeszek6Malgorzata Liszka7Malgorzata Liszka8Ali Alkhiat9Ali Alkhiat10Vladimir Mares11François Trompier12Sebastian Trinkl13Sebastian Trinkl14Immaculada Martínez-Rovira15Maite Romero-Expósito16Carles Domingo17Ondrej Ploc18Roger Harrison19Pawel Olko20Belgian Nuclear Research Center (SCK CEN), Institute for Environment, Health and Safety (EHS), Mol, BelgiumDanish Centre for Particle Therapy, Aarhus University Hospital (AUH), Aarhus, DenmarkInstitute of Nuclear Physics, Polish Academy of Sciences, (IFJ PAN), Krakow, PolandThe Skandion Clinic, Uppsala, SwedenSwedish Radiation Safety Authority, Solna, SwedenDepartment of Physics, Royal Institute of Technology (KTH), Stockholm, SwedenInstitute of Nuclear Physics, Polish Academy of Sciences, (IFJ PAN), Krakow, PolandInstitute of Nuclear Physics, Polish Academy of Sciences, (IFJ PAN), Krakow, PolandThe Skandion Clinic, Uppsala, SwedenThe Skandion Clinic, Uppsala, SwedenDepartment of Medical Radiation Physics and Nuclear Medicine, Karolinska University Hospital, Stockholm, SwedenHelmholtz Zentrum München, Institute of Radiation Medicine, Neuherberg, GermanyInstitut de Radioprotection et de Sûreté Nucléaire (IRSN), PSE-Santé, Fontenay-aux-Roses, FranceHelmholtz Zentrum München, Institute of Radiation Medicine, Neuherberg, Germany0Federal Office for Radiation Protection, Neuherberg, Germany1Departament de Física, Universitat Autònoma de Barcelona, Bellaterra, Spain1Departament de Física, Universitat Autònoma de Barcelona, Bellaterra, Spain1Departament de Física, Universitat Autònoma de Barcelona, Bellaterra, Spain2Department of Radiation Dosimetry, Nuclear Physics Institute of the Czech Academy of Sciences (CAS), Prague, Czechia3Faculty of Medical Sciences, University of Newcastle upon Tyne, Newcastle Upon Tyne, United KingdomInstitute of Nuclear Physics, Polish Academy of Sciences, (IFJ PAN), Krakow, PolandOut-of-field patient doses in proton therapy are dominated by neutrons. Currently, they are not taken into account by treatment planning systems. There is an increasing need to include out-of-field doses in the dose calculation, especially when treating children, pregnant patients, and patients with implants. In response to this demand, this work presents the first steps towards a tool for the prediction of out-of-field neutron doses in pencil beam scanning proton therapy facilities. As a first step, a general Monte Carlo radiation transport model for simulation of out-of-field neutron doses was set up and successfully verified by comparison of simulated and measured ambient neutron dose equivalent and neutron fluence energy spectra around a solid water phantom irradiated with a variation of different treatment plan parameters. Simulations with the verified model enabled a detailed study of the variation of the neutron ambient dose equivalent with field size, range, modulation width, use of a range shifter, and position inside the treatment room. For future work, it is planned to use this verified model to simulate out-of-field neutron doses inside the phantom and to verify the simulation results by comparison with previous in-phantom measurement campaigns. Eventually, these verified simulations will be used to build a library and a corresponding tool to allow assessment of out-of-field neutron doses at pencil beam scanning proton therapy facilities.https://www.frontiersin.org/articles/10.3389/fonc.2022.903537/fullProton therapyPencil beam scanned proton therapyNeutron dosesMonte Carlo simulationsOut-of-field neutron doses in radiation therapyNeutron measurements |
| spellingShingle | Olivier Van Hoey Liliana Stolarczyk Liliana Stolarczyk Liliana Stolarczyk Jan Lillhök Linda Eliasson Natalia Mojzeszek Malgorzata Liszka Malgorzata Liszka Ali Alkhiat Ali Alkhiat Vladimir Mares François Trompier Sebastian Trinkl Sebastian Trinkl Immaculada Martínez-Rovira Maite Romero-Expósito Carles Domingo Ondrej Ploc Roger Harrison Pawel Olko Simulation and experimental verification of ambient neutron doses in a pencil beam scanning proton therapy room as a function of treatment plan parameters Frontiers in Oncology Proton therapy Pencil beam scanned proton therapy Neutron doses Monte Carlo simulations Out-of-field neutron doses in radiation therapy Neutron measurements |
| title | Simulation and experimental verification of ambient neutron doses in a pencil beam scanning proton therapy room as a function of treatment plan parameters |
| title_full | Simulation and experimental verification of ambient neutron doses in a pencil beam scanning proton therapy room as a function of treatment plan parameters |
| title_fullStr | Simulation and experimental verification of ambient neutron doses in a pencil beam scanning proton therapy room as a function of treatment plan parameters |
| title_full_unstemmed | Simulation and experimental verification of ambient neutron doses in a pencil beam scanning proton therapy room as a function of treatment plan parameters |
| title_short | Simulation and experimental verification of ambient neutron doses in a pencil beam scanning proton therapy room as a function of treatment plan parameters |
| title_sort | simulation and experimental verification of ambient neutron doses in a pencil beam scanning proton therapy room as a function of treatment plan parameters |
| topic | Proton therapy Pencil beam scanned proton therapy Neutron doses Monte Carlo simulations Out-of-field neutron doses in radiation therapy Neutron measurements |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.903537/full |
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