Serum KL-6 levels predict the occurrence and severity of treatment-related interstitial lung disease in lung cancer
Abstract In this study, we aimed to investigate the feasibility of serum Krebs von den Lungen-6 (KL-6) as a potential biomarker for treatment-related ILD (TR-ILD) in lung cancer. We recruited patients with lung cancer in whom KL-6 was measured to differentiate between pneumonia and ILD (category 1),...
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| Format: | Article |
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Nature Portfolio
2023-10-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-45170-8 |
| _version_ | 1827634748201107456 |
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| author | Hwa Kyung Park Chang-Seok Yoon Young-Ok Na Jae-Kyeong Lee Hyung-Joo Oh Ha-Young Park Bo-Gun Kho Tae-Ok Kim Hong-Joon Shin Yong-Soo Kwon In-Jae Oh Yu-Il Kim Sung-Chul Lim Young-Chul Kim Cheol-Kyu Park |
| author_facet | Hwa Kyung Park Chang-Seok Yoon Young-Ok Na Jae-Kyeong Lee Hyung-Joo Oh Ha-Young Park Bo-Gun Kho Tae-Ok Kim Hong-Joon Shin Yong-Soo Kwon In-Jae Oh Yu-Il Kim Sung-Chul Lim Young-Chul Kim Cheol-Kyu Park |
| author_sort | Hwa Kyung Park |
| collection | DOAJ |
| description | Abstract In this study, we aimed to investigate the feasibility of serum Krebs von den Lungen-6 (KL-6) as a potential biomarker for treatment-related ILD (TR-ILD) in lung cancer. We recruited patients with lung cancer in whom KL-6 was measured to differentiate between pneumonia and ILD (category 1), diagnose and assess the severity of suspicious ILD (category 2), or evaluate baseline levels before cancer treatment (category 3). Among 1,297 patients who underwent KL-6 testing, 422 had lung cancer, and TR-ILD was detected in 195 patients. In categories 1–2, median KL-6 level was higher in drug-induced ILD or acute exacerbation of underlying ILD than in no ILD or radiation-induced pneumonitis, and it was correlated with the severity of TR-ILD. High KL-6 level (cut-off: > 436U/mL) was an independent risk factor for severe TR-ILD, and low KL-6 level with high procalcitonin level (> 0.5 ng/mL) could exclude severe TR-ILD. Patients with severe TR-ILD had worse overall survival than those without, whereas high baseline KL-6 level was associated with worse survival, especially in patients without severe TR-ILD. Therefore, serum KL-6 may be a surrogate marker for predicting the occurrence and assessing the severity of TR-ILD at the time of suspected ILD and before lung cancer treatment. |
| first_indexed | 2024-03-09T15:17:38Z |
| format | Article |
| id | doaj.art-81c90ec2cb2041d2941724abec98063b |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-09T15:17:38Z |
| publishDate | 2023-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-81c90ec2cb2041d2941724abec98063b2023-11-26T13:00:16ZengNature PortfolioScientific Reports2045-23222023-10-0113111310.1038/s41598-023-45170-8Serum KL-6 levels predict the occurrence and severity of treatment-related interstitial lung disease in lung cancerHwa Kyung Park0Chang-Seok Yoon1Young-Ok Na2Jae-Kyeong Lee3Hyung-Joo Oh4Ha-Young Park5Bo-Gun Kho6Tae-Ok Kim7Hong-Joon Shin8Yong-Soo Kwon9In-Jae Oh10Yu-Il Kim11Sung-Chul Lim12Young-Chul Kim13Cheol-Kyu Park14Lung Cancer Center, Chonnam National University Hwasun HospitalLung Cancer Center, Chonnam National University Hwasun HospitalDepartment of Internal Medicine, Chonnam National University Medical SchoolDepartment of Internal Medicine, Chonnam National University Medical SchoolLung Cancer Center, Chonnam National University Hwasun HospitalDepartment of Internal Medicine, Chonnam National University Medical SchoolDepartment of Internal Medicine, Chonnam National University Medical SchoolDepartment of Internal Medicine, Chonnam National University Medical SchoolDepartment of Internal Medicine, Chonnam National University Medical SchoolDepartment of Internal Medicine, Chonnam National University Medical SchoolLung Cancer Center, Chonnam National University Hwasun HospitalDepartment of Internal Medicine, Chonnam National University Medical SchoolDepartment of Internal Medicine, Chonnam National University Medical SchoolLung Cancer Center, Chonnam National University Hwasun HospitalLung Cancer Center, Chonnam National University Hwasun HospitalAbstract In this study, we aimed to investigate the feasibility of serum Krebs von den Lungen-6 (KL-6) as a potential biomarker for treatment-related ILD (TR-ILD) in lung cancer. We recruited patients with lung cancer in whom KL-6 was measured to differentiate between pneumonia and ILD (category 1), diagnose and assess the severity of suspicious ILD (category 2), or evaluate baseline levels before cancer treatment (category 3). Among 1,297 patients who underwent KL-6 testing, 422 had lung cancer, and TR-ILD was detected in 195 patients. In categories 1–2, median KL-6 level was higher in drug-induced ILD or acute exacerbation of underlying ILD than in no ILD or radiation-induced pneumonitis, and it was correlated with the severity of TR-ILD. High KL-6 level (cut-off: > 436U/mL) was an independent risk factor for severe TR-ILD, and low KL-6 level with high procalcitonin level (> 0.5 ng/mL) could exclude severe TR-ILD. Patients with severe TR-ILD had worse overall survival than those without, whereas high baseline KL-6 level was associated with worse survival, especially in patients without severe TR-ILD. Therefore, serum KL-6 may be a surrogate marker for predicting the occurrence and assessing the severity of TR-ILD at the time of suspected ILD and before lung cancer treatment.https://doi.org/10.1038/s41598-023-45170-8 |
| spellingShingle | Hwa Kyung Park Chang-Seok Yoon Young-Ok Na Jae-Kyeong Lee Hyung-Joo Oh Ha-Young Park Bo-Gun Kho Tae-Ok Kim Hong-Joon Shin Yong-Soo Kwon In-Jae Oh Yu-Il Kim Sung-Chul Lim Young-Chul Kim Cheol-Kyu Park Serum KL-6 levels predict the occurrence and severity of treatment-related interstitial lung disease in lung cancer Scientific Reports |
| title | Serum KL-6 levels predict the occurrence and severity of treatment-related interstitial lung disease in lung cancer |
| title_full | Serum KL-6 levels predict the occurrence and severity of treatment-related interstitial lung disease in lung cancer |
| title_fullStr | Serum KL-6 levels predict the occurrence and severity of treatment-related interstitial lung disease in lung cancer |
| title_full_unstemmed | Serum KL-6 levels predict the occurrence and severity of treatment-related interstitial lung disease in lung cancer |
| title_short | Serum KL-6 levels predict the occurrence and severity of treatment-related interstitial lung disease in lung cancer |
| title_sort | serum kl 6 levels predict the occurrence and severity of treatment related interstitial lung disease in lung cancer |
| url | https://doi.org/10.1038/s41598-023-45170-8 |
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