Characterization of a Novel SARS-CoV-2 Genetic Variant with Distinct Spike Protein Mutations
The COVID-19 pandemic, which began in Wuhan (Hubei, China), has been ongoing for about a year and a half. An unprecedented number of people around the world have been infected with SARS-CoV-2, the etiological agent of COVID-19. Despite the fact that the mortality rate for COVID-19 is relatively low,...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-05-01
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| Series: | Viruses |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4915/13/6/1029 |
| _version_ | 1797532063208833024 |
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| author | Anna Gladkikh Anna Dolgova Vladimir Dedkov Valeriya Sbarzaglia Olga Kanaeva Anna Popova Areg Totolian |
| author_facet | Anna Gladkikh Anna Dolgova Vladimir Dedkov Valeriya Sbarzaglia Olga Kanaeva Anna Popova Areg Totolian |
| author_sort | Anna Gladkikh |
| collection | DOAJ |
| description | The COVID-19 pandemic, which began in Wuhan (Hubei, China), has been ongoing for about a year and a half. An unprecedented number of people around the world have been infected with SARS-CoV-2, the etiological agent of COVID-19. Despite the fact that the mortality rate for COVID-19 is relatively low, the total number of deaths has currently already reached more than three million and continues to increase due to high incidence. Since the beginning of the pandemic, a large number of sequences have been obtained and many genetic variants have been identified. Some of them bear significant mutations that affect biological properties of the virus. These genetic variants, currently Variants of Concern (VoC), include the so-called United Kingdom variant (20I/501Y), the Brazilian variant (20J/501Y.V3), and the South African variant (20H/501Y.V2). We describe here a novel SARS-CoV-2 variant with distinct spike protein mutations, first obtained at the end of January 2021 in northwest Russia. Therefore, it is necessary to pay attention to the dynamics of its spread among patients with COVID-19, as well as to study in detail its biological properties. |
| first_indexed | 2024-03-10T10:53:44Z |
| format | Article |
| id | doaj.art-81c994f74b8740f8afb71806ac084551 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-10T10:53:44Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-81c994f74b8740f8afb71806ac0845512023-11-21T22:02:39ZengMDPI AGViruses1999-49152021-05-01136102910.3390/v13061029Characterization of a Novel SARS-CoV-2 Genetic Variant with Distinct Spike Protein MutationsAnna Gladkikh0Anna Dolgova1Vladimir Dedkov2Valeriya Sbarzaglia3Olga Kanaeva4Anna Popova5Areg Totolian6Saint Petersburg Pasteur Institute, 197101 Saint Petersburg, RussiaSaint Petersburg Pasteur Institute, 197101 Saint Petersburg, RussiaSaint Petersburg Pasteur Institute, 197101 Saint Petersburg, RussiaSaint Petersburg Pasteur Institute, 197101 Saint Petersburg, RussiaSaint Petersburg Pasteur Institute, 197101 Saint Petersburg, RussiaFederal Service for Surveillance on Consumer Rights Protection and Human Well-Being, 127994 Moscow, RussiaSaint Petersburg Pasteur Institute, 197101 Saint Petersburg, RussiaThe COVID-19 pandemic, which began in Wuhan (Hubei, China), has been ongoing for about a year and a half. An unprecedented number of people around the world have been infected with SARS-CoV-2, the etiological agent of COVID-19. Despite the fact that the mortality rate for COVID-19 is relatively low, the total number of deaths has currently already reached more than three million and continues to increase due to high incidence. Since the beginning of the pandemic, a large number of sequences have been obtained and many genetic variants have been identified. Some of them bear significant mutations that affect biological properties of the virus. These genetic variants, currently Variants of Concern (VoC), include the so-called United Kingdom variant (20I/501Y), the Brazilian variant (20J/501Y.V3), and the South African variant (20H/501Y.V2). We describe here a novel SARS-CoV-2 variant with distinct spike protein mutations, first obtained at the end of January 2021 in northwest Russia. Therefore, it is necessary to pay attention to the dynamics of its spread among patients with COVID-19, as well as to study in detail its biological properties.https://www.mdpi.com/1999-4915/13/6/1029SARS-CoV-2COVID-19variants of concernnorthwest (NW) variantRussia |
| spellingShingle | Anna Gladkikh Anna Dolgova Vladimir Dedkov Valeriya Sbarzaglia Olga Kanaeva Anna Popova Areg Totolian Characterization of a Novel SARS-CoV-2 Genetic Variant with Distinct Spike Protein Mutations Viruses SARS-CoV-2 COVID-19 variants of concern northwest (NW) variant Russia |
| title | Characterization of a Novel SARS-CoV-2 Genetic Variant with Distinct Spike Protein Mutations |
| title_full | Characterization of a Novel SARS-CoV-2 Genetic Variant with Distinct Spike Protein Mutations |
| title_fullStr | Characterization of a Novel SARS-CoV-2 Genetic Variant with Distinct Spike Protein Mutations |
| title_full_unstemmed | Characterization of a Novel SARS-CoV-2 Genetic Variant with Distinct Spike Protein Mutations |
| title_short | Characterization of a Novel SARS-CoV-2 Genetic Variant with Distinct Spike Protein Mutations |
| title_sort | characterization of a novel sars cov 2 genetic variant with distinct spike protein mutations |
| topic | SARS-CoV-2 COVID-19 variants of concern northwest (NW) variant Russia |
| url | https://www.mdpi.com/1999-4915/13/6/1029 |
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