E2F-1 has dual roles depending on the cell cycle
<p>The E2F family of transcription factors play a critical role in the control of cell proliferation. E2F-1 is the major cellular target of pRB and is regulated by pRB during cell proliferation. E2F-1-mediated activation and repression of target genes occurs in different settings. The role of...
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| Format: | Article |
| Language: | English |
| Published: |
Ivyspring International Publisher
2010-01-01
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| Series: | International Journal of Biological Sciences |
| Online Access: | http://www.biolsci.org/v06p0116.htm |
| _version_ | 1828334670507409408 |
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| author | Fikret Sahin, Todd L. Sladek |
| author_facet | Fikret Sahin, Todd L. Sladek |
| author_sort | Fikret Sahin, Todd L. Sladek |
| collection | DOAJ |
| description | <p>The E2F family of transcription factors play a critical role in the control of cell proliferation. E2F-1 is the major cellular target of pRB and is regulated by pRB during cell proliferation. E2F-1-mediated activation and repression of target genes occurs in different settings. The role of E2F-1 and E2F-1/pRB complexes in regulation of different target genes, and in cycling versus quiescent cells, is unclear. In this study, effects of free E2F-1 (doesn't complex with pRb) and E2F-1/pRb complex, on E2F-1 target gene expression were compared in different cell growth conditions. Findings suggest that E2F-1 acts in different ways, not only depending on the target gene but also depending on different stages of the cell cycle. For example, E2F-1 acts as part of the repression complex with pRB in the expression of DHFR, b-myb, TK and cdc2 in asynchronously growing cells; on the other hand, E2F-1 acts as an activator in the expression of the same genes in cells that are re-entering the cycle.</p> |
| first_indexed | 2024-04-13T21:36:09Z |
| format | Article |
| id | doaj.art-81c9975785c6433d8a136503a72ce12e |
| institution | Directory Open Access Journal |
| issn | 1449-2288 |
| language | English |
| last_indexed | 2024-04-13T21:36:09Z |
| publishDate | 2010-01-01 |
| publisher | Ivyspring International Publisher |
| record_format | Article |
| series | International Journal of Biological Sciences |
| spelling | doaj.art-81c9975785c6433d8a136503a72ce12e2022-12-22T02:28:58ZengIvyspring International PublisherInternational Journal of Biological Sciences1449-22882010-01-0162116128E2F-1 has dual roles depending on the cell cycleFikret Sahin, Todd L. Sladek<p>The E2F family of transcription factors play a critical role in the control of cell proliferation. E2F-1 is the major cellular target of pRB and is regulated by pRB during cell proliferation. E2F-1-mediated activation and repression of target genes occurs in different settings. The role of E2F-1 and E2F-1/pRB complexes in regulation of different target genes, and in cycling versus quiescent cells, is unclear. In this study, effects of free E2F-1 (doesn't complex with pRb) and E2F-1/pRb complex, on E2F-1 target gene expression were compared in different cell growth conditions. Findings suggest that E2F-1 acts in different ways, not only depending on the target gene but also depending on different stages of the cell cycle. For example, E2F-1 acts as part of the repression complex with pRB in the expression of DHFR, b-myb, TK and cdc2 in asynchronously growing cells; on the other hand, E2F-1 acts as an activator in the expression of the same genes in cells that are re-entering the cycle.</p>http://www.biolsci.org/v06p0116.htm |
| spellingShingle | Fikret Sahin, Todd L. Sladek E2F-1 has dual roles depending on the cell cycle International Journal of Biological Sciences |
| title | E2F-1 has dual roles depending on the cell cycle |
| title_full | E2F-1 has dual roles depending on the cell cycle |
| title_fullStr | E2F-1 has dual roles depending on the cell cycle |
| title_full_unstemmed | E2F-1 has dual roles depending on the cell cycle |
| title_short | E2F-1 has dual roles depending on the cell cycle |
| title_sort | e2f 1 has dual roles depending on the cell cycle |
| url | http://www.biolsci.org/v06p0116.htm |
| work_keys_str_mv | AT fikretsahintoddlsladek e2f1hasdualrolesdependingonthecellcycle |