An Engineered Pathway for Production of Terminally Sialylated N-glycoproteins in the Periplasm of Escherichia coli

An Engineered Pathway for Production of Terminally Sialylated N-glycoproteins in the Periplasm of Escherichia coli

Terminally sialylated N-glycoproteins are of great interest in therapeutic applications. Due to the inability of prokaryotes to carry out this post-translational modification, they are currently predominantly produced in eukaryotic host cells. In this study, we report a synthetic pathway to produce...

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Bibliographic Details
Main Authors: Jing Zhu, Yao Ruan, Xin Fu, Lichao Zhang, Gaoshun Ge, J. Gerard Wall, Teng Zou, Yang Zheng, Ning Ding, Xuejun Hu
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
sialylation
sialic acid
Escherichia coli
N-glycoprotein
α-2
6-sialyltransfease
Online Access:https://www.frontiersin.org/article/10.3389/fbioe.2020.00313/full

Internet

https://www.frontiersin.org/article/10.3389/fbioe.2020.00313/full

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