Transglutaminase 2 contributes to a TP53-induced autophagy program to prevent oncogenic transformation

Transglutaminase 2 contributes to a TP53-induced autophagy program to prevent oncogenic transformation

Genetic alterations which impair the function of the TP53 signaling pathway in TP53 wild-type human tumors remain elusive. To identify new components of this pathway, we performed a screen for genes whose loss-of-function debilitated TP53 signaling and enabled oncogenic transformation of human mamma...

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Bibliographic Details
Main Authors: Shi Yun Yeo, Yoko Itahana, Alvin Kunyao Guo, Rachel Han, Kozue Iwamoto, Hung Thanh Nguyen, Yi Bao, Kai Kleiber, Ya Jun Wu, Boon Huat Bay, Mathijs Voorhoeve, Koji Itahana
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-03-01
Series:eLife
Subjects:
TGM2
oncogenic transformation
TP53
autophagy
CDKN1A
Online Access:https://elifesciences.org/articles/07101

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