Foot drop - an uncommon presentation of FOLFOX toxicity
Chemotherapy based on FOLFOX (oxaliplatin, leucovorin, and 5-fluorouracil) regimen is frequently used in colorectal cancer patients. Oxaliplatin and other platinum agents are known to be a class of chemotherapy drugs that commonly induce peripheral neurotoxicity. The most frequent oxaliplatin relate...
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| Format: | Article |
| Language: | English |
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Associação Médica de Minas Gerais
2022-08-01
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| Series: | Revista Médica de Minas Gerais |
| Subjects: | |
| Online Access: | https://www.rmmg.org/artigo/detalhes/3929 |
| _version_ | 1797217447635320832 |
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| author | Tânia Madureira Joana Magalhães Pedro Bento Vilas Beatriz Gosálbez Irene Furtado |
| author_facet | Tânia Madureira Joana Magalhães Pedro Bento Vilas Beatriz Gosálbez Irene Furtado |
| author_sort | Tânia Madureira |
| collection | DOAJ |
| description | Chemotherapy based on FOLFOX (oxaliplatin, leucovorin, and 5-fluorouracil) regimen is frequently used in colorectal cancer patients. Oxaliplatin and other platinum agents are known to be a class of chemotherapy drugs that commonly induce peripheral neurotoxicity. The most frequent oxaliplatin related neurotoxicity is sensitive symptoms. Here, we present two cases of patients with colon adenocarcinoma, both undergoing chemotherapy with FOLFOX4, who developed uncommon neurotoxicity, presenting with foot drop after the third treatment cycle. Foot drop may be explained by axonal damage of peripheral motor neurons of the common peroneal (fibular) nerve, which provides motor innervation to the foot muscles. Peroneal nerve palsy causes sudden weakness in the muscles of the foot that seems to be temporary. Both patients completely recovered from the event. There was no need for treatment adjustments, neither introduction of different drugs. Foot drop as chemotherapy toxicity is still poorly understood. The reported cases show foot drop as a severe and uncommon manifestation of FOLFOX-induced neuropathy, that might be transitory, and does not necessarily requires specific intervention. |
| first_indexed | 2024-04-24T12:02:00Z |
| format | Article |
| id | doaj.art-81cf7b02cb154275842541c105824afc |
| institution | Directory Open Access Journal |
| issn | 0103-880X 2238-3182 |
| language | English |
| last_indexed | 2024-04-24T12:02:00Z |
| publishDate | 2022-08-01 |
| publisher | Associação Médica de Minas Gerais |
| record_format | Article |
| series | Revista Médica de Minas Gerais |
| spelling | doaj.art-81cf7b02cb154275842541c105824afc2024-04-08T16:30:11ZengAssociação Médica de Minas GeraisRevista Médica de Minas Gerais0103-880X2238-31822022-08-0132e-32406https://dx.doi.org/10.5935/2238-3182.2022e32406Foot drop - an uncommon presentation of FOLFOX toxicityTânia Madureira0Joana Magalhães1Pedro Bento Vilas2Beatriz Gosálbez3Irene Furtado4University Hospital Center of Algarve, Medical Oncology Department, Faro, PortugalUniversity Hospital Center of Algarve, Medical Oncology Department, Faro, PortugalUniversity Hospital Center of Algarve, Medical Oncology Department, Faro, PortugalUniversity Hospital Center of Algarve, Medical Oncology Department, Faro, PortugalUniversity Hospital Center of Algarve, Internal Medicine Department, Faro, PortugaChemotherapy based on FOLFOX (oxaliplatin, leucovorin, and 5-fluorouracil) regimen is frequently used in colorectal cancer patients. Oxaliplatin and other platinum agents are known to be a class of chemotherapy drugs that commonly induce peripheral neurotoxicity. The most frequent oxaliplatin related neurotoxicity is sensitive symptoms. Here, we present two cases of patients with colon adenocarcinoma, both undergoing chemotherapy with FOLFOX4, who developed uncommon neurotoxicity, presenting with foot drop after the third treatment cycle. Foot drop may be explained by axonal damage of peripheral motor neurons of the common peroneal (fibular) nerve, which provides motor innervation to the foot muscles. Peroneal nerve palsy causes sudden weakness in the muscles of the foot that seems to be temporary. Both patients completely recovered from the event. There was no need for treatment adjustments, neither introduction of different drugs. Foot drop as chemotherapy toxicity is still poorly understood. The reported cases show foot drop as a severe and uncommon manifestation of FOLFOX-induced neuropathy, that might be transitory, and does not necessarily requires specific intervention.https://www.rmmg.org/artigo/detalhes/3929foot dropoxaliplatinneurotoxicity |
| spellingShingle | Tânia Madureira Joana Magalhães Pedro Bento Vilas Beatriz Gosálbez Irene Furtado Foot drop - an uncommon presentation of FOLFOX toxicity Revista Médica de Minas Gerais foot drop oxaliplatin neurotoxicity |
| title | Foot drop - an uncommon presentation of FOLFOX toxicity |
| title_full | Foot drop - an uncommon presentation of FOLFOX toxicity |
| title_fullStr | Foot drop - an uncommon presentation of FOLFOX toxicity |
| title_full_unstemmed | Foot drop - an uncommon presentation of FOLFOX toxicity |
| title_short | Foot drop - an uncommon presentation of FOLFOX toxicity |
| title_sort | foot drop an uncommon presentation of folfox toxicity |
| topic | foot drop oxaliplatin neurotoxicity |
| url | https://www.rmmg.org/artigo/detalhes/3929 |
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