Multiple Evolutionarily Conserved Domains of Cap2 Are Required for Promoter Recruitment and Iron Homeostasis Gene Regulation

Multiple Evolutionarily Conserved Domains of Cap2 Are Required for Promoter Recruitment and Iron Homeostasis Gene Regulation

ABSTRACT Iron is required for growth and metabolism by virtually all organisms. The human fungal pathogen Candida albicans has evolved multiple strategies to acquire iron. The Cap2/Hap43 transcriptional regulator, essential for robust virulence of C. albicans, controls iron homeostasis gene expressi...

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Bibliographic Details
Main Authors: Manjit Kumar Srivastav, Neha Agarwal, Krishnamurthy Natarajan
Format: Article
Language:English
Published: American Society for Microbiology 2018-08-01
Series:mSphere
Subjects:
Candida albicans
Cap2/Hap43
iron homeostasis
transcriptional regulation
Online Access:https://journals.asm.org/doi/10.1128/mSphere.00370-18

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