Oxidative Cellular Damage and the Reduction of APE/Ref-1 Expression after Experimental Traumatic Brain Injury

Oxidative Cellular Damage and the Reduction of APE/Ref-1 Expression after Experimental Traumatic Brain Injury

The DNA repair enzyme, apurinic/apyrimidinic endonuclease (or redox effector factor-1, APE/Ref-1), is involved in base excision repair of apurinic/apyrimidinic sites after oxidative DNA damage. We investigated the expression of APE/Ref-1 and its relationship to oxidative stress after severe traumati...

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Bibliographic Details
Main Authors: Anders Lewén, Taku Sugawara, Yvan Gasche, Miki Fujimura, Pak H. Chan
Format: Article
Language:English
Published: Elsevier 2001-06-01
Series:Neurobiology of Disease
Subjects:
traumatic brain injury
mice
cellular injury
oxidative stress
DNA repair
DNA oxidation
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996101903961

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