Central role of the sentinel acute pancreatitis event (SAPE) model in understanding recurrent acute pancreatitis (RAP): Implications for precision medicine
Traditional approaches to understanding the origins of chronic pancreatitis (CP) and find treatments led to abysmal failure. Thus, no drugs now exists to meet this need. Outdated concepts of the etiopathogenesis of CP have been replaced with new insights and disease models that provide the framework...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Pediatrics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fped.2022.941852/full |
| _version_ | 1828300980719976448 |
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| author | David C. Whitcomb David C. Whitcomb |
| author_facet | David C. Whitcomb David C. Whitcomb |
| author_sort | David C. Whitcomb |
| collection | DOAJ |
| description | Traditional approaches to understanding the origins of chronic pancreatitis (CP) and find treatments led to abysmal failure. Thus, no drugs now exists to meet this need. Outdated concepts of the etiopathogenesis of CP have been replaced with new insights and disease models that provide the framework for early detection of the pathogenic pancreatitis process. Application of these principals require a new paradigm in disease definition and management, i.e. personalized / precision medicine. The key is acute pancreatitis (AP) starting with the first (sentinel) acute pancreatitis (AP) event (SAPE). This event sensitizes the pancreas to recurrent acute pancreatitis (RAP) as ongoing stressors drive various inflammatory responses to cause CP. The problem is the complex etiologies of AP and the additional genetic and environmental factors that promote progression to RAP and CP. This paper provides a background on the key conceptual changes that facilitate new approaches and the rationale for using mechanism-specific therapies to prevent RAP and CP. |
| first_indexed | 2024-04-13T13:17:25Z |
| format | Article |
| id | doaj.art-81d324cffa974e37ad61cc7d32e4bde0 |
| institution | Directory Open Access Journal |
| issn | 2296-2360 |
| language | English |
| last_indexed | 2024-04-13T13:17:25Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pediatrics |
| spelling | doaj.art-81d324cffa974e37ad61cc7d32e4bde02022-12-22T02:45:25ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602022-08-011010.3389/fped.2022.941852941852Central role of the sentinel acute pancreatitis event (SAPE) model in understanding recurrent acute pancreatitis (RAP): Implications for precision medicineDavid C. Whitcomb0David C. Whitcomb1Cell Biology and Molecular Physiology, and Human Genetics, Division of Gastroenterology, Hepatology and Nutrition (Chief 1999-2016), University of Pittsburgh and UPMC, Pittsburgh, PA, United StatesAriel Precision Medicine, Pittsburgh, PA, United StatesTraditional approaches to understanding the origins of chronic pancreatitis (CP) and find treatments led to abysmal failure. Thus, no drugs now exists to meet this need. Outdated concepts of the etiopathogenesis of CP have been replaced with new insights and disease models that provide the framework for early detection of the pathogenic pancreatitis process. Application of these principals require a new paradigm in disease definition and management, i.e. personalized / precision medicine. The key is acute pancreatitis (AP) starting with the first (sentinel) acute pancreatitis (AP) event (SAPE). This event sensitizes the pancreas to recurrent acute pancreatitis (RAP) as ongoing stressors drive various inflammatory responses to cause CP. The problem is the complex etiologies of AP and the additional genetic and environmental factors that promote progression to RAP and CP. This paper provides a background on the key conceptual changes that facilitate new approaches and the rationale for using mechanism-specific therapies to prevent RAP and CP.https://www.frontiersin.org/articles/10.3389/fped.2022.941852/fullchronic pancreatitis in childrenprecision medicinegeneticsrecurrent acute pancreatitisCFTR (cystic fibrosis transmembrane conductance regulator)CFTR-related disorders (CFTR-RD) |
| spellingShingle | David C. Whitcomb David C. Whitcomb Central role of the sentinel acute pancreatitis event (SAPE) model in understanding recurrent acute pancreatitis (RAP): Implications for precision medicine Frontiers in Pediatrics chronic pancreatitis in children precision medicine genetics recurrent acute pancreatitis CFTR (cystic fibrosis transmembrane conductance regulator) CFTR-related disorders (CFTR-RD) |
| title | Central role of the sentinel acute pancreatitis event (SAPE) model in understanding recurrent acute pancreatitis (RAP): Implications for precision medicine |
| title_full | Central role of the sentinel acute pancreatitis event (SAPE) model in understanding recurrent acute pancreatitis (RAP): Implications for precision medicine |
| title_fullStr | Central role of the sentinel acute pancreatitis event (SAPE) model in understanding recurrent acute pancreatitis (RAP): Implications for precision medicine |
| title_full_unstemmed | Central role of the sentinel acute pancreatitis event (SAPE) model in understanding recurrent acute pancreatitis (RAP): Implications for precision medicine |
| title_short | Central role of the sentinel acute pancreatitis event (SAPE) model in understanding recurrent acute pancreatitis (RAP): Implications for precision medicine |
| title_sort | central role of the sentinel acute pancreatitis event sape model in understanding recurrent acute pancreatitis rap implications for precision medicine |
| topic | chronic pancreatitis in children precision medicine genetics recurrent acute pancreatitis CFTR (cystic fibrosis transmembrane conductance regulator) CFTR-related disorders (CFTR-RD) |
| url | https://www.frontiersin.org/articles/10.3389/fped.2022.941852/full |
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