Clinical characteristics of dry eye in patients with type 2 diabetic peripheral neuropathy
AIM: To investigate the clinical features of dry eye in patients with type 2 diabetes mellitus complicated with peripheral neuropathy.METHOD: Prospective cohort study. A total of 192 patients with type 2 diabetes were enrolled in the Department of Endocrinology, Shuguang Hospital Affiliated to Shang...
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| Format: | Article |
| Language: | English |
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Press of International Journal of Ophthalmology (IJO PRESS)
2023-06-01
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| Series: | Guoji Yanke Zazhi |
| Subjects: | |
| Online Access: | http://ies.ijo.cn/cn_publish/2023/6/202306019.pdf |
| _version_ | 1797816807384416256 |
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| author | Meng-Xue Yao Ying Yu Lei-Lei Wang |
| author_facet | Meng-Xue Yao Ying Yu Lei-Lei Wang |
| author_sort | Meng-Xue Yao |
| collection | DOAJ |
| description | AIM: To investigate the clinical features of dry eye in patients with type 2 diabetes mellitus complicated with peripheral neuropathy.METHOD: Prospective cohort study. A total of 192 patients with type 2 diabetes were enrolled in the Department of Endocrinology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine from July 2021 to March 2022. The right eyes of all patients were selected as the observation eye, among which 122 patients were diagnosed with diabetic peripheral neuropathy(DPN)and 70 patients were diagnosed with non-diabetic peripheral neuropathy(NDPN). The score of ocular surface disease index(OSDI), tear meniscus height, tear meniscus width, corneal epithelial thickness, corneal endothelial cell density, tear secretion test(Schirmer Ⅰ test, SⅠt), corneal sensitivity, meibomian gland function status score, tear film breakup time(BUT), corneal fluorescein sodium staining score and Toronto clinical scoring system(TCSS)score were compared between two groups. The correlation between OSDI score and TCSS score in type 2 diabetes patients was analyzed as well.RESULTS: The morbidity of dry eye in the DPN group(55 eyes, 45.1%)was significantly higher than that of NDPN group(20 eyes, 28.6%; χ2=5.094, P=0.024), BUT and corneal sensitivity score of DPN were lower than NDPN group(P<0.001), meanwhile, corneal staining score and meibomian gland function score were higher than NDPN group(P<0.001). OSDI scores of all subjects were negatively correlated with TCSS scores(rs=-0.233, P=0.002), and OSDI scores of DPN group were negatively correlated with TCSS scores(rs=-0.511, P<0.001), but there was no significant correlation between the two scores of NDPN patients(rs=0.007, P=0.957).CONCLUSIONS: DPN patients are more likely to develop dry eye than NDPN patients. OSDI score is not an accurate evaluation index for type 2 diabetes patients, especially for DPN patients. |
| first_indexed | 2024-03-13T08:43:11Z |
| format | Article |
| id | doaj.art-81d334b22d84491c8a89bbed83e77b64 |
| institution | Directory Open Access Journal |
| issn | 1672-5123 |
| language | English |
| last_indexed | 2024-03-13T08:43:11Z |
| publishDate | 2023-06-01 |
| publisher | Press of International Journal of Ophthalmology (IJO PRESS) |
| record_format | Article |
| series | Guoji Yanke Zazhi |
| spelling | doaj.art-81d334b22d84491c8a89bbed83e77b642023-05-30T07:55:53ZengPress of International Journal of Ophthalmology (IJO PRESS)Guoji Yanke Zazhi1672-51232023-06-0123697798010.3980/j.issn.1672-5123.2023.6.19202306019Clinical characteristics of dry eye in patients with type 2 diabetic peripheral neuropathyMeng-Xue Yao0Ying Yu1Lei-Lei Wang2Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China; Shanghai Aier Qingliang Eye Hospital Co., Ltd., Shanghai 201700, ChinaDepartment of Ophthalmology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, ChinaShanghai University of Traditional Chinese Medicine, Shanghai 201203, China; Shanghai Eye Diseases Prevention & Treatment Center;Shanghai Eye Hospital, Shanghai 200336, ChinaAIM: To investigate the clinical features of dry eye in patients with type 2 diabetes mellitus complicated with peripheral neuropathy.METHOD: Prospective cohort study. A total of 192 patients with type 2 diabetes were enrolled in the Department of Endocrinology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine from July 2021 to March 2022. The right eyes of all patients were selected as the observation eye, among which 122 patients were diagnosed with diabetic peripheral neuropathy(DPN)and 70 patients were diagnosed with non-diabetic peripheral neuropathy(NDPN). The score of ocular surface disease index(OSDI), tear meniscus height, tear meniscus width, corneal epithelial thickness, corneal endothelial cell density, tear secretion test(Schirmer Ⅰ test, SⅠt), corneal sensitivity, meibomian gland function status score, tear film breakup time(BUT), corneal fluorescein sodium staining score and Toronto clinical scoring system(TCSS)score were compared between two groups. The correlation between OSDI score and TCSS score in type 2 diabetes patients was analyzed as well.RESULTS: The morbidity of dry eye in the DPN group(55 eyes, 45.1%)was significantly higher than that of NDPN group(20 eyes, 28.6%; χ2=5.094, P=0.024), BUT and corneal sensitivity score of DPN were lower than NDPN group(P<0.001), meanwhile, corneal staining score and meibomian gland function score were higher than NDPN group(P<0.001). OSDI scores of all subjects were negatively correlated with TCSS scores(rs=-0.233, P=0.002), and OSDI scores of DPN group were negatively correlated with TCSS scores(rs=-0.511, P<0.001), but there was no significant correlation between the two scores of NDPN patients(rs=0.007, P=0.957).CONCLUSIONS: DPN patients are more likely to develop dry eye than NDPN patients. OSDI score is not an accurate evaluation index for type 2 diabetes patients, especially for DPN patients.http://ies.ijo.cn/cn_publish/2023/6/202306019.pdfdiabetic peripheral neuropathydry eyetoronto clinical scoring system scoreocular surface disease index score |
| spellingShingle | Meng-Xue Yao Ying Yu Lei-Lei Wang Clinical characteristics of dry eye in patients with type 2 diabetic peripheral neuropathy Guoji Yanke Zazhi diabetic peripheral neuropathy dry eye toronto clinical scoring system score ocular surface disease index score |
| title | Clinical characteristics of dry eye in patients with type 2 diabetic peripheral neuropathy |
| title_full | Clinical characteristics of dry eye in patients with type 2 diabetic peripheral neuropathy |
| title_fullStr | Clinical characteristics of dry eye in patients with type 2 diabetic peripheral neuropathy |
| title_full_unstemmed | Clinical characteristics of dry eye in patients with type 2 diabetic peripheral neuropathy |
| title_short | Clinical characteristics of dry eye in patients with type 2 diabetic peripheral neuropathy |
| title_sort | clinical characteristics of dry eye in patients with type 2 diabetic peripheral neuropathy |
| topic | diabetic peripheral neuropathy dry eye toronto clinical scoring system score ocular surface disease index score |
| url | http://ies.ijo.cn/cn_publish/2023/6/202306019.pdf |
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