Lung development and regeneration: newly defined cell types and progenitor status
Abstract The lung is the most critical organ of the respiratory system supporting gas exchange. Constant interaction with the external environment makes the lung vulnerable to injury. Thus, a deeper understanding of cellular and molecular processes underlying lung development programs and evaluation...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SpringerOpen
2023-04-01
|
| Series: | Cell Regeneration |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13619-022-00149-0 |
| _version_ | 1797850039307993088 |
|---|---|
| author | Xiaogao Meng Guizhong Cui Guangdun Peng |
| author_facet | Xiaogao Meng Guizhong Cui Guangdun Peng |
| author_sort | Xiaogao Meng |
| collection | DOAJ |
| description | Abstract The lung is the most critical organ of the respiratory system supporting gas exchange. Constant interaction with the external environment makes the lung vulnerable to injury. Thus, a deeper understanding of cellular and molecular processes underlying lung development programs and evaluation of progenitor status within the lung is an essential part of lung regenerative medicine. In this review, we aim to discuss the current understanding of lung development process and regenerative capability. We highlight the advances brought by multi-omics approaches, single-cell transcriptome, in particular, that can help us further dissect the cellular player and molecular signaling underlying those processes. |
| first_indexed | 2024-04-09T18:53:56Z |
| format | Article |
| id | doaj.art-81d6549d98f94b8980c9d51e8be8abba |
| institution | Directory Open Access Journal |
| issn | 2045-9769 |
| language | English |
| last_indexed | 2024-04-09T18:53:56Z |
| publishDate | 2023-04-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Cell Regeneration |
| spelling | doaj.art-81d6549d98f94b8980c9d51e8be8abba2023-04-09T11:18:11ZengSpringerOpenCell Regeneration2045-97692023-04-0112111310.1186/s13619-022-00149-0Lung development and regeneration: newly defined cell types and progenitor statusXiaogao Meng0Guizhong Cui1Guangdun Peng2Center for Cell Lineage and Development, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of SciencesSchool of Basic Medical Sciences, Guangzhou Laboratory, Guangzhou Medical UniversityCenter for Cell Lineage and Development, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of SciencesAbstract The lung is the most critical organ of the respiratory system supporting gas exchange. Constant interaction with the external environment makes the lung vulnerable to injury. Thus, a deeper understanding of cellular and molecular processes underlying lung development programs and evaluation of progenitor status within the lung is an essential part of lung regenerative medicine. In this review, we aim to discuss the current understanding of lung development process and regenerative capability. We highlight the advances brought by multi-omics approaches, single-cell transcriptome, in particular, that can help us further dissect the cellular player and molecular signaling underlying those processes.https://doi.org/10.1186/s13619-022-00149-0Lung developmentRegenerationStem cellProgenitorscRNA-seqLineage tracing |
| spellingShingle | Xiaogao Meng Guizhong Cui Guangdun Peng Lung development and regeneration: newly defined cell types and progenitor status Cell Regeneration Lung development Regeneration Stem cell Progenitor scRNA-seq Lineage tracing |
| title | Lung development and regeneration: newly defined cell types and progenitor status |
| title_full | Lung development and regeneration: newly defined cell types and progenitor status |
| title_fullStr | Lung development and regeneration: newly defined cell types and progenitor status |
| title_full_unstemmed | Lung development and regeneration: newly defined cell types and progenitor status |
| title_short | Lung development and regeneration: newly defined cell types and progenitor status |
| title_sort | lung development and regeneration newly defined cell types and progenitor status |
| topic | Lung development Regeneration Stem cell Progenitor scRNA-seq Lineage tracing |
| url | https://doi.org/10.1186/s13619-022-00149-0 |
| work_keys_str_mv | AT xiaogaomeng lungdevelopmentandregenerationnewlydefinedcelltypesandprogenitorstatus AT guizhongcui lungdevelopmentandregenerationnewlydefinedcelltypesandprogenitorstatus AT guangdunpeng lungdevelopmentandregenerationnewlydefinedcelltypesandprogenitorstatus |