A Clinicopathological Report of a 93-Year-Old Former Street Boxer With Coexistence of Chronic Traumatic Encephalopathy, Alzheimer's Disease, Dementia With Lewy Bodies, and Hippocampal Sclerosis With TDP-43 Pathology
Chronic traumatic encephalopathy (CTE) was recently recognized as a new tauopathy in which multifocal perivascular phosphorylated tau aggregates accumulate in neurons, astrocytes, and neurites at the depths of the cortical sulci. Traumatic brain injury (TBI) in early or mid-life is known to be assoc...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-02-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fneur.2020.00042/full |
| _version_ | 1819078078176952320 |
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| author | Chunhui Yang Sukriti Nag Sukriti Nag Guoqiang Xing Neelum T. Aggarwal Neelum T. Aggarwal Julie A. Schneider Julie A. Schneider Julie A. Schneider |
| author_facet | Chunhui Yang Sukriti Nag Sukriti Nag Guoqiang Xing Neelum T. Aggarwal Neelum T. Aggarwal Julie A. Schneider Julie A. Schneider Julie A. Schneider |
| author_sort | Chunhui Yang |
| collection | DOAJ |
| description | Chronic traumatic encephalopathy (CTE) was recently recognized as a new tauopathy in which multifocal perivascular phosphorylated tau aggregates accumulate in neurons, astrocytes, and neurites at the depths of the cortical sulci. Traumatic brain injury (TBI) in early or mid-life is known to be associated with an increased risk of dementia in late life. This case report describes a 93-year-old former street boxer with a premortem diagnosis of severe dementia, who showed pathological evidence of the coexistence of Alzheimer's disease, CTE, dementia with Lewy bodies, and hippocampal sclerosis with TDP-43 pathology. These findings suggest that TBI may trigger a variety of misfolded proteins leading to dementia. Currently, clear clinical diagnostic criteria for CTE have not been established. Therefore, clinicians should be aware that TBI is a risk factor for dementia and that CTE can overlap with other neurodegenerative diseases. |
| first_indexed | 2024-12-21T19:07:22Z |
| format | Article |
| id | doaj.art-81d6b3b0ae154fa2bbc32859a992d996 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-12-21T19:07:22Z |
| publishDate | 2020-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-81d6b3b0ae154fa2bbc32859a992d9962022-12-21T18:53:18ZengFrontiers Media S.A.Frontiers in Neurology1664-22952020-02-011110.3389/fneur.2020.00042493123A Clinicopathological Report of a 93-Year-Old Former Street Boxer With Coexistence of Chronic Traumatic Encephalopathy, Alzheimer's Disease, Dementia With Lewy Bodies, and Hippocampal Sclerosis With TDP-43 PathologyChunhui Yang0Sukriti Nag1Sukriti Nag2Guoqiang Xing3Neelum T. Aggarwal4Neelum T. Aggarwal5Julie A. Schneider6Julie A. Schneider7Julie A. Schneider8Rush Alzheimer Disease Center, Rush University Medical Center, Chicago, IL, United StatesRush Alzheimer Disease Center, Rush University Medical Center, Chicago, IL, United StatesDepartment of Pathology (Neuropathology), Rush University Medical Center, Chicago, IL, United StatesThe Affiliated Hospital of the North Sichuan Medical College, Nanchong, ChinaRush Alzheimer Disease Center, Rush University Medical Center, Chicago, IL, United StatesDepartment of Neurological Sciences, Rush University Medical Center, Chicago, IL, United StatesRush Alzheimer Disease Center, Rush University Medical Center, Chicago, IL, United StatesDepartment of Pathology (Neuropathology), Rush University Medical Center, Chicago, IL, United StatesDepartment of Neurological Sciences, Rush University Medical Center, Chicago, IL, United StatesChronic traumatic encephalopathy (CTE) was recently recognized as a new tauopathy in which multifocal perivascular phosphorylated tau aggregates accumulate in neurons, astrocytes, and neurites at the depths of the cortical sulci. Traumatic brain injury (TBI) in early or mid-life is known to be associated with an increased risk of dementia in late life. This case report describes a 93-year-old former street boxer with a premortem diagnosis of severe dementia, who showed pathological evidence of the coexistence of Alzheimer's disease, CTE, dementia with Lewy bodies, and hippocampal sclerosis with TDP-43 pathology. These findings suggest that TBI may trigger a variety of misfolded proteins leading to dementia. Currently, clear clinical diagnostic criteria for CTE have not been established. Therefore, clinicians should be aware that TBI is a risk factor for dementia and that CTE can overlap with other neurodegenerative diseases.https://www.frontiersin.org/article/10.3389/fneur.2020.00042/fullAlzheimer's diseasechronic traumatic encephalopathydementiadementia with Lewy bodiesphosphorylated tautraumatic brain injury |
| spellingShingle | Chunhui Yang Sukriti Nag Sukriti Nag Guoqiang Xing Neelum T. Aggarwal Neelum T. Aggarwal Julie A. Schneider Julie A. Schneider Julie A. Schneider A Clinicopathological Report of a 93-Year-Old Former Street Boxer With Coexistence of Chronic Traumatic Encephalopathy, Alzheimer's Disease, Dementia With Lewy Bodies, and Hippocampal Sclerosis With TDP-43 Pathology Frontiers in Neurology Alzheimer's disease chronic traumatic encephalopathy dementia dementia with Lewy bodies phosphorylated tau traumatic brain injury |
| title | A Clinicopathological Report of a 93-Year-Old Former Street Boxer With Coexistence of Chronic Traumatic Encephalopathy, Alzheimer's Disease, Dementia With Lewy Bodies, and Hippocampal Sclerosis With TDP-43 Pathology |
| title_full | A Clinicopathological Report of a 93-Year-Old Former Street Boxer With Coexistence of Chronic Traumatic Encephalopathy, Alzheimer's Disease, Dementia With Lewy Bodies, and Hippocampal Sclerosis With TDP-43 Pathology |
| title_fullStr | A Clinicopathological Report of a 93-Year-Old Former Street Boxer With Coexistence of Chronic Traumatic Encephalopathy, Alzheimer's Disease, Dementia With Lewy Bodies, and Hippocampal Sclerosis With TDP-43 Pathology |
| title_full_unstemmed | A Clinicopathological Report of a 93-Year-Old Former Street Boxer With Coexistence of Chronic Traumatic Encephalopathy, Alzheimer's Disease, Dementia With Lewy Bodies, and Hippocampal Sclerosis With TDP-43 Pathology |
| title_short | A Clinicopathological Report of a 93-Year-Old Former Street Boxer With Coexistence of Chronic Traumatic Encephalopathy, Alzheimer's Disease, Dementia With Lewy Bodies, and Hippocampal Sclerosis With TDP-43 Pathology |
| title_sort | clinicopathological report of a 93 year old former street boxer with coexistence of chronic traumatic encephalopathy alzheimer s disease dementia with lewy bodies and hippocampal sclerosis with tdp 43 pathology |
| topic | Alzheimer's disease chronic traumatic encephalopathy dementia dementia with Lewy bodies phosphorylated tau traumatic brain injury |
| url | https://www.frontiersin.org/article/10.3389/fneur.2020.00042/full |
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