Extremely Rare Case of Fetal Anemia Due to Mitochondrial Disease Managed with Intrauterine Transfusion
This report describes a rare case of fetal anemia, confirmed as a mitochondrial disease after birth, treated with intrauterine transfusion (IUT). Although mitochondrial diseases have been described in newborns, research on their prenatal features is lacking. A patient was referred to our institution...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-02-01
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| Series: | Medicina |
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| Online Access: | https://www.mdpi.com/1648-9144/58/3/328 |
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| author | Jinha Chung Mi-Young Lee Jin-Hoon Chung Hye-Sung Won |
| author_facet | Jinha Chung Mi-Young Lee Jin-Hoon Chung Hye-Sung Won |
| author_sort | Jinha Chung |
| collection | DOAJ |
| description | This report describes a rare case of fetal anemia, confirmed as a mitochondrial disease after birth, treated with intrauterine transfusion (IUT). Although mitochondrial diseases have been described in newborns, research on their prenatal features is lacking. A patient was referred to our institution at 32 gestational weeks owing to fetal hydrops. Fetal anemia was confirmed by cordocentesis. After IUT had been performed three times, the anemia and associated fetal hydrops showed improvement. However, after birth, the neonate had recurrent pancytopenia and lactic acidosis. He was eventually diagnosed with Pearson syndrome and died 2 months after birth. This is the first case report of fetal anemia associated with mitochondrial disease managed with IUT. |
| first_indexed | 2024-03-09T13:24:26Z |
| format | Article |
| id | doaj.art-81d7eef98126451a92f6cd61ab83437a |
| institution | Directory Open Access Journal |
| issn | 1010-660X 1648-9144 |
| language | English |
| last_indexed | 2024-03-09T13:24:26Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj.art-81d7eef98126451a92f6cd61ab83437a2023-11-30T21:25:23ZengMDPI AGMedicina1010-660X1648-91442022-02-0158332810.3390/medicina58030328Extremely Rare Case of Fetal Anemia Due to Mitochondrial Disease Managed with Intrauterine TransfusionJinha Chung0Mi-Young Lee1Jin-Hoon Chung2Hye-Sung Won3Department of Obstetrics and Gynecology, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-ro 43-gil, Songpa-gu, Seoul 05505, KoreaDepartment of Obstetrics and Gynecology, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-ro 43-gil, Songpa-gu, Seoul 05505, KoreaDepartment of Obstetrics and Gynecology, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-ro 43-gil, Songpa-gu, Seoul 05505, KoreaDepartment of Obstetrics and Gynecology, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-ro 43-gil, Songpa-gu, Seoul 05505, KoreaThis report describes a rare case of fetal anemia, confirmed as a mitochondrial disease after birth, treated with intrauterine transfusion (IUT). Although mitochondrial diseases have been described in newborns, research on their prenatal features is lacking. A patient was referred to our institution at 32 gestational weeks owing to fetal hydrops. Fetal anemia was confirmed by cordocentesis. After IUT had been performed three times, the anemia and associated fetal hydrops showed improvement. However, after birth, the neonate had recurrent pancytopenia and lactic acidosis. He was eventually diagnosed with Pearson syndrome and died 2 months after birth. This is the first case report of fetal anemia associated with mitochondrial disease managed with IUT.https://www.mdpi.com/1648-9144/58/3/328anemiablood transfusioncase reporthydrops fetalismitochondrial diseasesPearson syndrome |
| spellingShingle | Jinha Chung Mi-Young Lee Jin-Hoon Chung Hye-Sung Won Extremely Rare Case of Fetal Anemia Due to Mitochondrial Disease Managed with Intrauterine Transfusion Medicina anemia blood transfusion case report hydrops fetalis mitochondrial diseases Pearson syndrome |
| title | Extremely Rare Case of Fetal Anemia Due to Mitochondrial Disease Managed with Intrauterine Transfusion |
| title_full | Extremely Rare Case of Fetal Anemia Due to Mitochondrial Disease Managed with Intrauterine Transfusion |
| title_fullStr | Extremely Rare Case of Fetal Anemia Due to Mitochondrial Disease Managed with Intrauterine Transfusion |
| title_full_unstemmed | Extremely Rare Case of Fetal Anemia Due to Mitochondrial Disease Managed with Intrauterine Transfusion |
| title_short | Extremely Rare Case of Fetal Anemia Due to Mitochondrial Disease Managed with Intrauterine Transfusion |
| title_sort | extremely rare case of fetal anemia due to mitochondrial disease managed with intrauterine transfusion |
| topic | anemia blood transfusion case report hydrops fetalis mitochondrial diseases Pearson syndrome |
| url | https://www.mdpi.com/1648-9144/58/3/328 |
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