Phylogenomic Characterization of Lopma Virus and Praja Virus, Two Novel Rodent-Borne Arteriviruses
Recent years have witnessed the discovery of several new viruses belonging to the family <i>Arteriviridae</i>, expanding the known diversity and host range of this group of complex RNA viruses. Although the pathological relevance of these new viruses is not always clear, several well-stu...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-09-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/13/9/1842 |
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| author | Bert Vanmechelen Zafeiro Zisi Sophie Gryseels Joëlle Goüy de Bellocq Bram Vrancken Philippe Lemey Piet Maes Magda Bletsa |
| author_facet | Bert Vanmechelen Zafeiro Zisi Sophie Gryseels Joëlle Goüy de Bellocq Bram Vrancken Philippe Lemey Piet Maes Magda Bletsa |
| author_sort | Bert Vanmechelen |
| collection | DOAJ |
| description | Recent years have witnessed the discovery of several new viruses belonging to the family <i>Arteriviridae</i>, expanding the known diversity and host range of this group of complex RNA viruses. Although the pathological relevance of these new viruses is not always clear, several well-studied members of the family <i>Arteriviridae</i> are known to be important animal pathogens. Here, we report the complete genome sequences of four new arterivirus variants, belonging to two putative novel species. These new arteriviruses were discovered in African rodents and were given the names Lopma virus and Praja virus. Their genomes follow the characteristic genome organization of all known arteriviruses, even though they are only distantly related to currently known rodent-borne arteriviruses. Phylogenetic analysis shows that Lopma virus clusters in the subfamily <i>Variarterivirinae</i>, while Praja virus clusters near members of the subfamily <i>Heroarterivirinae</i>: the yet undescribed forest pouched giant rat arterivirus and hedgehog arterivirus 1. A co-divergence analysis of rodent-borne arteriviruses confirms that they share similar phylogenetic patterns with their hosts, with only very few cases of host shifting events throughout their evolutionary history. Overall, the genomes described here and their unique clustering with other arteriviruses further illustrate the existence of multiple rodent-borne arterivirus lineages, expanding our knowledge of the evolutionary origin of these viruses. |
| first_indexed | 2024-03-10T07:08:45Z |
| format | Article |
| id | doaj.art-81d9d563bdcf49a684a752790345dcc3 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-10T07:08:45Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-81d9d563bdcf49a684a752790345dcc32023-11-22T15:38:48ZengMDPI AGViruses1999-49152021-09-01139184210.3390/v13091842Phylogenomic Characterization of Lopma Virus and Praja Virus, Two Novel Rodent-Borne ArterivirusesBert Vanmechelen0Zafeiro Zisi1Sophie Gryseels2Joëlle Goüy de Bellocq3Bram Vrancken4Philippe Lemey5Piet Maes6Magda Bletsa7Laboratory of Clinical and Epidemiological Virology, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, KU Leuven, Herestraat 49/Box 1040, 3000 Leuven, BelgiumLaboratory of Clinical and Epidemiological Virology, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, KU Leuven, Herestraat 49/Box 1040, 3000 Leuven, BelgiumEvolutionary Ecology Group, Department of Biology, University of Antwerp, Universiteitsplein 1, 2610 Wilrijk, BelgiumInstitute of Vertebrate Biology, The Czech Academy of Sciences, Květná 8, 603 65 Brno, Czech RepublicLaboratory of Clinical and Epidemiological Virology, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, KU Leuven, Herestraat 49/Box 1040, 3000 Leuven, BelgiumLaboratory of Clinical and Epidemiological Virology, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, KU Leuven, Herestraat 49/Box 1040, 3000 Leuven, BelgiumLaboratory of Clinical and Epidemiological Virology, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, KU Leuven, Herestraat 49/Box 1040, 3000 Leuven, BelgiumLaboratory of Clinical and Epidemiological Virology, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, KU Leuven, Herestraat 49/Box 1040, 3000 Leuven, BelgiumRecent years have witnessed the discovery of several new viruses belonging to the family <i>Arteriviridae</i>, expanding the known diversity and host range of this group of complex RNA viruses. Although the pathological relevance of these new viruses is not always clear, several well-studied members of the family <i>Arteriviridae</i> are known to be important animal pathogens. Here, we report the complete genome sequences of four new arterivirus variants, belonging to two putative novel species. These new arteriviruses were discovered in African rodents and were given the names Lopma virus and Praja virus. Their genomes follow the characteristic genome organization of all known arteriviruses, even though they are only distantly related to currently known rodent-borne arteriviruses. Phylogenetic analysis shows that Lopma virus clusters in the subfamily <i>Variarterivirinae</i>, while Praja virus clusters near members of the subfamily <i>Heroarterivirinae</i>: the yet undescribed forest pouched giant rat arterivirus and hedgehog arterivirus 1. A co-divergence analysis of rodent-borne arteriviruses confirms that they share similar phylogenetic patterns with their hosts, with only very few cases of host shifting events throughout their evolutionary history. Overall, the genomes described here and their unique clustering with other arteriviruses further illustrate the existence of multiple rodent-borne arterivirus lineages, expanding our knowledge of the evolutionary origin of these viruses.https://www.mdpi.com/1999-4915/13/9/1842<i>Arteriviridae</i>rodent-borne arteriviruseshost spectrumcross-species transmissionvirus evolution |
| spellingShingle | Bert Vanmechelen Zafeiro Zisi Sophie Gryseels Joëlle Goüy de Bellocq Bram Vrancken Philippe Lemey Piet Maes Magda Bletsa Phylogenomic Characterization of Lopma Virus and Praja Virus, Two Novel Rodent-Borne Arteriviruses Viruses <i>Arteriviridae</i> rodent-borne arteriviruses host spectrum cross-species transmission virus evolution |
| title | Phylogenomic Characterization of Lopma Virus and Praja Virus, Two Novel Rodent-Borne Arteriviruses |
| title_full | Phylogenomic Characterization of Lopma Virus and Praja Virus, Two Novel Rodent-Borne Arteriviruses |
| title_fullStr | Phylogenomic Characterization of Lopma Virus and Praja Virus, Two Novel Rodent-Borne Arteriviruses |
| title_full_unstemmed | Phylogenomic Characterization of Lopma Virus and Praja Virus, Two Novel Rodent-Borne Arteriviruses |
| title_short | Phylogenomic Characterization of Lopma Virus and Praja Virus, Two Novel Rodent-Borne Arteriviruses |
| title_sort | phylogenomic characterization of lopma virus and praja virus two novel rodent borne arteriviruses |
| topic | <i>Arteriviridae</i> rodent-borne arteriviruses host spectrum cross-species transmission virus evolution |
| url | https://www.mdpi.com/1999-4915/13/9/1842 |
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