Associations between TNFSF13B polymorphisms and primary Sjögren's syndrome susceptibility in primary Sjögren's syndrome patients: A meta‐analysis
Abstract Objective B‐cell activating factor (BAFF) is a key regulator of primary Sjögren's syndrome (pSS), which is characterized by B‐lymphocyte hyperactivity. BAFF, also known as tumor necrosis factor ligand superfamily member 13B, is encoded by TNFSF13B. This study aimed to explore the possi...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-12-01
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| Series: | Immunity, Inflammation and Disease |
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| Online Access: | https://doi.org/10.1002/iid3.1103 |
| _version_ | 1797372795411234816 |
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| author | Anhao Zheng Naiwen Hu Jing Xu Ye Yuan Shumin Zhang Wenbin Chen Yanyan Bai Hongsheng Sun |
| author_facet | Anhao Zheng Naiwen Hu Jing Xu Ye Yuan Shumin Zhang Wenbin Chen Yanyan Bai Hongsheng Sun |
| author_sort | Anhao Zheng |
| collection | DOAJ |
| description | Abstract Objective B‐cell activating factor (BAFF) is a key regulator of primary Sjögren's syndrome (pSS), which is characterized by B‐lymphocyte hyperactivity. BAFF, also known as tumor necrosis factor ligand superfamily member 13B, is encoded by TNFSF13B. This study aimed to explore the possible relationships between five single‐nucleotide polymorphisms (SNPs) of TNFSF13B (rs9514827, rs1041569, rs9514828, rs1224141, and rs12583006) and pSS susceptibility. Methods We searched the following databases for articles on TNFSF13B polymorphism and pSS published up to January 2023: PubMed, Cochrane, Elsevier, Web of Science, CNKI, CQVIP, and WanFang. The odds ratios (with 95% confidence intervals) of genotypes and SNP alleles of TNFSF13B were investigated in patients with pSS to determine their relationships with pSS. Results This meta‐analysis employing the fixed‐effect model comprised three studies of pSS patients and randomly selected healthy controls (HCs), revealing statistically significant relationships between pSS susceptibility and two SNPs: rs1041569 and rs12583006. Because rs1041569 was not in Hardy‐Weinberg equilibrium in the HC group, it was eliminated from the analysis. Conclusions Polymorphisms in the BAFF (TNFSF13B) gene were related to vulnerability to pSS among pSS patients and HCs alike. The SNP rs12583006 was significantly related to pSS susceptibility in pSS patients. |
| first_indexed | 2024-03-08T18:39:59Z |
| format | Article |
| id | doaj.art-81da6efef62840c6a47b846b96888e9f |
| institution | Directory Open Access Journal |
| issn | 2050-4527 |
| language | English |
| last_indexed | 2024-03-08T18:39:59Z |
| publishDate | 2023-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | Immunity, Inflammation and Disease |
| spelling | doaj.art-81da6efef62840c6a47b846b96888e9f2023-12-29T08:52:36ZengWileyImmunity, Inflammation and Disease2050-45272023-12-011112n/an/a10.1002/iid3.1103Associations between TNFSF13B polymorphisms and primary Sjögren's syndrome susceptibility in primary Sjögren's syndrome patients: A meta‐analysisAnhao Zheng0Naiwen Hu1Jing Xu2Ye Yuan3Shumin Zhang4Wenbin Chen5Yanyan Bai6Hongsheng Sun7Medical Integration and Practice Center Cheeloo College of Medicine, Shandong University Jinan ChinaDepartment of Rheumatology and Immunology Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University Jinan ChinaGraduate School Shandong First Medical University Jinan ChinaGraduate School Shandong First Medical University Jinan ChinaGraduate School Shandong First Medical University Jinan ChinaDepartment of Rheumatology and Immunology Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University Jinan ChinaDepartment of Rheumatology and Immunology Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University Jinan ChinaDepartment of Rheumatology and Immunology Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University Jinan ChinaAbstract Objective B‐cell activating factor (BAFF) is a key regulator of primary Sjögren's syndrome (pSS), which is characterized by B‐lymphocyte hyperactivity. BAFF, also known as tumor necrosis factor ligand superfamily member 13B, is encoded by TNFSF13B. This study aimed to explore the possible relationships between five single‐nucleotide polymorphisms (SNPs) of TNFSF13B (rs9514827, rs1041569, rs9514828, rs1224141, and rs12583006) and pSS susceptibility. Methods We searched the following databases for articles on TNFSF13B polymorphism and pSS published up to January 2023: PubMed, Cochrane, Elsevier, Web of Science, CNKI, CQVIP, and WanFang. The odds ratios (with 95% confidence intervals) of genotypes and SNP alleles of TNFSF13B were investigated in patients with pSS to determine their relationships with pSS. Results This meta‐analysis employing the fixed‐effect model comprised three studies of pSS patients and randomly selected healthy controls (HCs), revealing statistically significant relationships between pSS susceptibility and two SNPs: rs1041569 and rs12583006. Because rs1041569 was not in Hardy‐Weinberg equilibrium in the HC group, it was eliminated from the analysis. Conclusions Polymorphisms in the BAFF (TNFSF13B) gene were related to vulnerability to pSS among pSS patients and HCs alike. The SNP rs12583006 was significantly related to pSS susceptibility in pSS patients.https://doi.org/10.1002/iid3.1103B‐cell activating factormeta‐analysispolymorphismSjögren's syndromeTNFSF13B |
| spellingShingle | Anhao Zheng Naiwen Hu Jing Xu Ye Yuan Shumin Zhang Wenbin Chen Yanyan Bai Hongsheng Sun Associations between TNFSF13B polymorphisms and primary Sjögren's syndrome susceptibility in primary Sjögren's syndrome patients: A meta‐analysis Immunity, Inflammation and Disease B‐cell activating factor meta‐analysis polymorphism Sjögren's syndrome TNFSF13B |
| title | Associations between TNFSF13B polymorphisms and primary Sjögren's syndrome susceptibility in primary Sjögren's syndrome patients: A meta‐analysis |
| title_full | Associations between TNFSF13B polymorphisms and primary Sjögren's syndrome susceptibility in primary Sjögren's syndrome patients: A meta‐analysis |
| title_fullStr | Associations between TNFSF13B polymorphisms and primary Sjögren's syndrome susceptibility in primary Sjögren's syndrome patients: A meta‐analysis |
| title_full_unstemmed | Associations between TNFSF13B polymorphisms and primary Sjögren's syndrome susceptibility in primary Sjögren's syndrome patients: A meta‐analysis |
| title_short | Associations between TNFSF13B polymorphisms and primary Sjögren's syndrome susceptibility in primary Sjögren's syndrome patients: A meta‐analysis |
| title_sort | associations between tnfsf13b polymorphisms and primary sjogren s syndrome susceptibility in primary sjogren s syndrome patients a meta analysis |
| topic | B‐cell activating factor meta‐analysis polymorphism Sjögren's syndrome TNFSF13B |
| url | https://doi.org/10.1002/iid3.1103 |
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