Pevonedistat Suppresses Pancreatic Cancer Growth via Inactivation of the Neddylation Pathway

Pevonedistat Suppresses Pancreatic Cancer Growth via Inactivation of the Neddylation Pathway

BackgroundThe neddylation pathway is aberrantly overactivated in multiple human cancers and has been indicated as an effective target for anticancer therapy in clinical trials. We aimed to study whether the neddylation pathway is upregulated in pancreatic cancer and whether pevonedistat, a first-in-...

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Bibliographic Details
Main Authors: Junfeng Xu, Zheng Li, Qifeng Zhuo, Zeng Ye, Guixiong Fan, Heli Gao, Shunrong Ji, Xianjun Yu, Xiaowu Xu, Wensheng Liu, Wenyan Xu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-01-01
Series:Frontiers in Oncology
Subjects:
neddylation pathway
pevonedistat
pancreatic cancer therapy
cell growth
cell cycle
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.822039/full

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