Airborne Transmission of Avian Origin H9N2 Influenza A Viruses in Mammals
Influenza A viruses (IAV) are widespread viruses affecting avian and mammalian species worldwide. IAVs from avian species can be transmitted to mammals including humans and, thus, they are of inherent pandemic concern. Most of the efforts to understand the pathogenicity and transmission of avian ori...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-09-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/13/10/1919 |
| _version_ | 1827678462478909440 |
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| author | C. Joaquín Cáceres Daniela S. Rajao Daniel R. Perez |
| author_facet | C. Joaquín Cáceres Daniela S. Rajao Daniel R. Perez |
| author_sort | C. Joaquín Cáceres |
| collection | DOAJ |
| description | Influenza A viruses (IAV) are widespread viruses affecting avian and mammalian species worldwide. IAVs from avian species can be transmitted to mammals including humans and, thus, they are of inherent pandemic concern. Most of the efforts to understand the pathogenicity and transmission of avian origin IAVs have been focused on H5 and H7 subtypes due to their highly pathogenic phenotype in poultry. However, IAV of the H9 subtype, which circulate endemically in poultry flocks in some regions of the world, have also been associated with cases of zoonotic infections. In this review, we discuss the mammalian transmission of H9N2 and the molecular factors that are thought relevant for this spillover, focusing on the HA segment. Additionally, we discuss factors that have been associated with the ability of these viruses to transmit through the respiratory route in mammalian species. The summarized information shows that minimal amino acid changes in the HA and/or the combination of H9N2 surface genes with internal genes of human influenza viruses are enough for the generation of H9N2 viruses with the ability to transmit via aerosol. |
| first_indexed | 2024-03-10T06:08:35Z |
| format | Article |
| id | doaj.art-81dae6a0b5c84c4683c571dd1cc61124 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-10T06:08:35Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-81dae6a0b5c84c4683c571dd1cc611242023-11-22T20:18:03ZengMDPI AGViruses1999-49152021-09-011310191910.3390/v13101919Airborne Transmission of Avian Origin H9N2 Influenza A Viruses in MammalsC. Joaquín Cáceres0Daniela S. Rajao1Daniel R. Perez2Department of Population Health, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USADepartment of Population Health, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USADepartment of Population Health, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USAInfluenza A viruses (IAV) are widespread viruses affecting avian and mammalian species worldwide. IAVs from avian species can be transmitted to mammals including humans and, thus, they are of inherent pandemic concern. Most of the efforts to understand the pathogenicity and transmission of avian origin IAVs have been focused on H5 and H7 subtypes due to their highly pathogenic phenotype in poultry. However, IAV of the H9 subtype, which circulate endemically in poultry flocks in some regions of the world, have also been associated with cases of zoonotic infections. In this review, we discuss the mammalian transmission of H9N2 and the molecular factors that are thought relevant for this spillover, focusing on the HA segment. Additionally, we discuss factors that have been associated with the ability of these viruses to transmit through the respiratory route in mammalian species. The summarized information shows that minimal amino acid changes in the HA and/or the combination of H9N2 surface genes with internal genes of human influenza viruses are enough for the generation of H9N2 viruses with the ability to transmit via aerosol.https://www.mdpi.com/1999-4915/13/10/1919H9N2influenzaaerosolinterspeciesmammalszoonotic |
| spellingShingle | C. Joaquín Cáceres Daniela S. Rajao Daniel R. Perez Airborne Transmission of Avian Origin H9N2 Influenza A Viruses in Mammals Viruses H9N2 influenza aerosol interspecies mammals zoonotic |
| title | Airborne Transmission of Avian Origin H9N2 Influenza A Viruses in Mammals |
| title_full | Airborne Transmission of Avian Origin H9N2 Influenza A Viruses in Mammals |
| title_fullStr | Airborne Transmission of Avian Origin H9N2 Influenza A Viruses in Mammals |
| title_full_unstemmed | Airborne Transmission of Avian Origin H9N2 Influenza A Viruses in Mammals |
| title_short | Airborne Transmission of Avian Origin H9N2 Influenza A Viruses in Mammals |
| title_sort | airborne transmission of avian origin h9n2 influenza a viruses in mammals |
| topic | H9N2 influenza aerosol interspecies mammals zoonotic |
| url | https://www.mdpi.com/1999-4915/13/10/1919 |
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