Reductions in Hydrogen Sulfide and Changes in Mitochondrial Quality Control Proteins Are Evident in the Early Phases of the Corneally Kindled Mouse Model of Epilepsy

Reductions in Hydrogen Sulfide and Changes in Mitochondrial Quality Control Proteins Are Evident in the Early Phases of the Corneally Kindled Mouse Model of Epilepsy

Epilepsy is a heterogenous neurological disorder characterized by recurrent unprovoked seizures, mitochondrial stress, and neurodegeneration. Hydrogen sulfide (H<sub>2</sub>S) is a gasotransmitter that promotes mitochondrial function and biogenesis, elicits neuromodulation and neuroprote...

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Bibliographic Details
Main Authors: Christi Cho, Maxwell Zeigler, Stephanie Mizuno, Richard S. Morrison, Rheem A. Totah, Melissa Barker-Haliski
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:International Journal of Molecular Sciences
Subjects:
epilepsy
hydrogen sulfide
corneally kindled mice
mitochondrial dysfunction
oxidative stress
LC-MS/MS
Online Access:https://www.mdpi.com/1422-0067/23/3/1434

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