Platelet microvesicles in health and disease
Interest in cell-derived extracellular vesicles and their physiological and pathological implications is constantly growing. Microvesicles, also known as microparticles, are small extracellular vesicles released by cells in response to activation or apoptosis. Among the different microvesicles prese...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2017-04-01
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| Series: | Platelets |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/09537104.2016.1265924 |
| _version_ | 1827816920411275264 |
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| author | Imene Melki Nicolas Tessandier Anne Zufferey Eric Boilard |
| author_facet | Imene Melki Nicolas Tessandier Anne Zufferey Eric Boilard |
| author_sort | Imene Melki |
| collection | DOAJ |
| description | Interest in cell-derived extracellular vesicles and their physiological and pathological implications is constantly growing. Microvesicles, also known as microparticles, are small extracellular vesicles released by cells in response to activation or apoptosis. Among the different microvesicles present in the blood of healthy individuals, platelet-derived microvesicles (PMVs) are the most abundant. Their characterization has revealed a heterogeneous cargo that includes a set of adhesion molecules. Similarly to platelets, PMVs are also involved in thrombosis through support of the coagulation cascade. The levels of circulatory PMVs are altered during several disease manifestations such as coagulation disorders, rheumatoid arthritis, systemic lupus erythematosus, cancers, cardiovascular diseases, and infections, pointing to their potential contribution to disease and their development as a biomarker. This review highlights recent findings in the field of PMV research and addresses their contribution to both healthy and diseased states. |
| first_indexed | 2024-03-12T00:28:15Z |
| format | Article |
| id | doaj.art-81dcb387198d4b9b9397a071a7e8620e |
| institution | Directory Open Access Journal |
| issn | 0953-7104 1369-1635 |
| language | English |
| last_indexed | 2024-03-12T00:28:15Z |
| publishDate | 2017-04-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Platelets |
| spelling | doaj.art-81dcb387198d4b9b9397a071a7e8620e2023-09-15T10:31:57ZengTaylor & Francis GroupPlatelets0953-71041369-16352017-04-0128321422110.1080/09537104.2016.12659241265924Platelet microvesicles in health and diseaseImene Melki0Nicolas Tessandier1Anne Zufferey2Eric Boilard3Centre de Recherche du Centre Hospitalier Universitaire de Québec, Faculty of MedicineCentre de Recherche du Centre Hospitalier Universitaire de Québec, Faculty of MedicineCentre de Recherche du Centre Hospitalier Universitaire de Québec, Faculty of MedicineCentre de Recherche du Centre Hospitalier Universitaire de Québec, Faculty of MedicineInterest in cell-derived extracellular vesicles and their physiological and pathological implications is constantly growing. Microvesicles, also known as microparticles, are small extracellular vesicles released by cells in response to activation or apoptosis. Among the different microvesicles present in the blood of healthy individuals, platelet-derived microvesicles (PMVs) are the most abundant. Their characterization has revealed a heterogeneous cargo that includes a set of adhesion molecules. Similarly to platelets, PMVs are also involved in thrombosis through support of the coagulation cascade. The levels of circulatory PMVs are altered during several disease manifestations such as coagulation disorders, rheumatoid arthritis, systemic lupus erythematosus, cancers, cardiovascular diseases, and infections, pointing to their potential contribution to disease and their development as a biomarker. This review highlights recent findings in the field of PMV research and addresses their contribution to both healthy and diseased states.http://dx.doi.org/10.1080/09537104.2016.1265924diseasehealthmicrovesiclesplatelet microparticles |
| spellingShingle | Imene Melki Nicolas Tessandier Anne Zufferey Eric Boilard Platelet microvesicles in health and disease Platelets disease health microvesicles platelet microparticles |
| title | Platelet microvesicles in health and disease |
| title_full | Platelet microvesicles in health and disease |
| title_fullStr | Platelet microvesicles in health and disease |
| title_full_unstemmed | Platelet microvesicles in health and disease |
| title_short | Platelet microvesicles in health and disease |
| title_sort | platelet microvesicles in health and disease |
| topic | disease health microvesicles platelet microparticles |
| url | http://dx.doi.org/10.1080/09537104.2016.1265924 |
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