Zika virus infection of mature neurons from immunocompetent mice generates a disease-associated microglia and a tauopathy-like phenotype in link with a delayed interferon beta response

Zika virus infection of mature neurons from immunocompetent mice generates a disease-associated microglia and a tauopathy-like phenotype in link with a delayed interferon beta response

Abstract Background Zika virus (ZIKV) infection at postnatal or adult age can lead to neurological disorders associated with cognitive defects. Yet, how mature neurons respond to ZIKV remains substantially unexplored. Methods The impact of ZIKV infection on mature neurons and microglia was analyzed...

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Bibliographic Details
Main Authors: Caroline Manet, Zeyni Mansuroglu, Laurine Conquet, Violaine Bortolin, Thomas Comptdaer, Helena Segrt, Marie Bourdon, Reyene Menidjel, Nicolas Stadler, Guanfang Tian, Floriane Herit, Florence Niedergang, Sylvie Souès, Luc Buée, Marie-Christine Galas, Xavier Montagutelli, Eliette Bonnefoy
Format: Article
Language:English
Published: BMC 2022-12-01
Series:Journal of Neuroinflammation
Subjects:
Zika virus
Interferon beta
Tau protein
Collaborative cross
Disease associated microglia
Neuron-microglia crosstalk
Online Access:https://doi.org/10.1186/s12974-022-02668-8

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