Trefoil Factor 3 Protein and Sepsis
Sepsis is one of the most common causes of death in hospitalized patients. Disruption of intestinal barrier homeostasis is one of its main hallmarks. Trefoil factor family proteins are known for their role in protecting and repairing the intestinal mucosa. It has been repeatedly shown that the TFF3...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Faculty of Medicine Osijek
2022-11-01
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| Series: | Southeastern European Medical Journal |
| Subjects: | |
| Online Access: | http://seemedj.mefos.unios.hr/index.php/seemedj/article/view/253/138 |
| _version_ | 1797986726097977344 |
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| author | Iva Bazina Mirela Baus Lončar |
| author_facet | Iva Bazina Mirela Baus Lončar |
| author_sort | Iva Bazina |
| collection | DOAJ |
| description | Sepsis is one of the most common causes of death in hospitalized patients. Disruption of intestinal barrier homeostasis is one of its main hallmarks. Trefoil factor family proteins are known for their role in protecting and repairing the intestinal mucosa. It has been repeatedly shown that the TFF3 protein is involved in maintaining the intestinal barrier. For that reason, it has been studied in the search for objective measures to predict the onset or outcome of sepsis. Several studies have been performed on rodent sepsis models and on sepsis patients, both children and adults. From the limited research available to date, it appears that TFF3 is involved in the pathogenesis of sepsis, but the exact mechanism is not yet clear. Its potential as a sepsis biomarker has so far been low, but more extensive studies on its role in predicting disease severity and outcome, as well as organ dysfunction, may lead to finding specific patient groups or sepsis stages for which it would be suitable. |
| first_indexed | 2024-04-11T07:36:36Z |
| format | Article |
| id | doaj.art-81e10884ec02408c86d9836d8ada2504 |
| institution | Directory Open Access Journal |
| issn | 2459-9484 |
| language | English |
| last_indexed | 2024-04-11T07:36:36Z |
| publishDate | 2022-11-01 |
| publisher | Faculty of Medicine Osijek |
| record_format | Article |
| series | Southeastern European Medical Journal |
| spelling | doaj.art-81e10884ec02408c86d9836d8ada25042022-12-22T04:36:43ZengFaculty of Medicine OsijekSoutheastern European Medical Journal2459-94842022-11-0162445310.26332/seemedj.v6i2.253Trefoil Factor 3 Protein and SepsisIva Bazina0Mirela Baus Lončar1Department of Molecular Medicine, Ruđer Bošković Institute, Zagreb, CroatiaDepartment of Molecular Medicine, Ruđer Bošković Institute, Zagreb, CroatiaSepsis is one of the most common causes of death in hospitalized patients. Disruption of intestinal barrier homeostasis is one of its main hallmarks. Trefoil factor family proteins are known for their role in protecting and repairing the intestinal mucosa. It has been repeatedly shown that the TFF3 protein is involved in maintaining the intestinal barrier. For that reason, it has been studied in the search for objective measures to predict the onset or outcome of sepsis. Several studies have been performed on rodent sepsis models and on sepsis patients, both children and adults. From the limited research available to date, it appears that TFF3 is involved in the pathogenesis of sepsis, but the exact mechanism is not yet clear. Its potential as a sepsis biomarker has so far been low, but more extensive studies on its role in predicting disease severity and outcome, as well as organ dysfunction, may lead to finding specific patient groups or sepsis stages for which it would be suitable.http://seemedj.mefos.unios.hr/index.php/seemedj/article/view/253/138sepsistrefoil factor 3 (tff3)biomarkerintestinal mucosal barrier disruptionserum tff3 |
| spellingShingle | Iva Bazina Mirela Baus Lončar Trefoil Factor 3 Protein and Sepsis Southeastern European Medical Journal sepsis trefoil factor 3 (tff3) biomarker intestinal mucosal barrier disruption serum tff3 |
| title | Trefoil Factor 3 Protein and Sepsis |
| title_full | Trefoil Factor 3 Protein and Sepsis |
| title_fullStr | Trefoil Factor 3 Protein and Sepsis |
| title_full_unstemmed | Trefoil Factor 3 Protein and Sepsis |
| title_short | Trefoil Factor 3 Protein and Sepsis |
| title_sort | trefoil factor 3 protein and sepsis |
| topic | sepsis trefoil factor 3 (tff3) biomarker intestinal mucosal barrier disruption serum tff3 |
| url | http://seemedj.mefos.unios.hr/index.php/seemedj/article/view/253/138 |
| work_keys_str_mv | AT ivabazina trefoilfactor3proteinandsepsis AT mirelabausloncar trefoilfactor3proteinandsepsis |