FUNDC1: A Promising Mitophagy Regulator at the Mitochondria-Associated Membrane for Cardiovascular Diseases
Mitochondrial autophagy (or mitophagy) regulates the mitochondrial network and function to contribute to multiple cellular processes. The protective effect of homeostatic mitophagy in cardiovascular diseases (CVDs) has attracted increasing attention. FUN14 domain containing 1 (FUNDC1), an identified...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-12-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2021.788634/full |
| _version_ | 1818361708026003456 |
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| author | Guoyong Li Guoyong Li Guoyong Li Junli Li Ruochen Shao Ruochen Shao Ruochen Shao Jiahao Zhao Jiahao Zhao Mao Chen Mao Chen |
| author_facet | Guoyong Li Guoyong Li Guoyong Li Junli Li Ruochen Shao Ruochen Shao Ruochen Shao Jiahao Zhao Jiahao Zhao Mao Chen Mao Chen |
| author_sort | Guoyong Li |
| collection | DOAJ |
| description | Mitochondrial autophagy (or mitophagy) regulates the mitochondrial network and function to contribute to multiple cellular processes. The protective effect of homeostatic mitophagy in cardiovascular diseases (CVDs) has attracted increasing attention. FUN14 domain containing 1 (FUNDC1), an identified mitophagy receptor, plays an essential role in CVDs. Different expression levels of FUNDC1 and its phosphorylated state at different sites alleviate or exacerbate hypoxia and ischemia/reperfusion injury, cardiac hypertrophy, or metabolic damage through promotion or inhibition of mitophagy. In addition, FUNDC1 can be enriched at contact sites between mitochondria and the endoplasmic reticulum (ER), determining the formation of mitochondria-associated membranes (MAMs) that regulate cellular calcium (Ca2+) homeostasis and mitochondrial dynamics to prevent heart dysfunction. Moreover, FUNDC1 has also been involved in inflammatory cardiac diseases such as septic cardiomyopathy. In this review, we collect and summarize the evidence on the roles of FUNDC1 exclusively in various CVDs, describing its interactions with different cellular organelles, its involvement in multiple cellular processes, and its associated signaling pathways. FUNDC1 may become a promising therapeutic target for the prevention and management of various CVDs. |
| first_indexed | 2024-12-13T21:20:58Z |
| format | Article |
| id | doaj.art-81e2422a4c8b4f399b29ce069fb35612 |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-12-13T21:20:58Z |
| publishDate | 2021-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-81e2422a4c8b4f399b29ce069fb356122022-12-21T23:31:06ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2021-12-01910.3389/fcell.2021.788634788634FUNDC1: A Promising Mitophagy Regulator at the Mitochondria-Associated Membrane for Cardiovascular DiseasesGuoyong Li0Guoyong Li1Guoyong Li2Junli Li3Ruochen Shao4Ruochen Shao5Ruochen Shao6Jiahao Zhao7Jiahao Zhao8Mao Chen9Mao Chen10Laboratory of Heart Valve Disease, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Cardiology, West China Hospital, Sichuan University, Chengdu, ChinaWest China School of Medicine, Sichuan University, Chengdu, ChinaLaboratory of Heart Valve Disease, West China Hospital, Sichuan University, Chengdu, ChinaLaboratory of Heart Valve Disease, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Cardiology, West China Hospital, Sichuan University, Chengdu, ChinaWest China School of Medicine, Sichuan University, Chengdu, ChinaLaboratory of Heart Valve Disease, West China Hospital, Sichuan University, Chengdu, ChinaWest China School of Medicine, Sichuan University, Chengdu, ChinaDepartment of Cardiology, West China Hospital, Sichuan University, Chengdu, ChinaLaboratory of Heart Valve Disease, West China Hospital, Sichuan University, Chengdu, ChinaMitochondrial autophagy (or mitophagy) regulates the mitochondrial network and function to contribute to multiple cellular processes. The protective effect of homeostatic mitophagy in cardiovascular diseases (CVDs) has attracted increasing attention. FUN14 domain containing 1 (FUNDC1), an identified mitophagy receptor, plays an essential role in CVDs. Different expression levels of FUNDC1 and its phosphorylated state at different sites alleviate or exacerbate hypoxia and ischemia/reperfusion injury, cardiac hypertrophy, or metabolic damage through promotion or inhibition of mitophagy. In addition, FUNDC1 can be enriched at contact sites between mitochondria and the endoplasmic reticulum (ER), determining the formation of mitochondria-associated membranes (MAMs) that regulate cellular calcium (Ca2+) homeostasis and mitochondrial dynamics to prevent heart dysfunction. Moreover, FUNDC1 has also been involved in inflammatory cardiac diseases such as septic cardiomyopathy. In this review, we collect and summarize the evidence on the roles of FUNDC1 exclusively in various CVDs, describing its interactions with different cellular organelles, its involvement in multiple cellular processes, and its associated signaling pathways. FUNDC1 may become a promising therapeutic target for the prevention and management of various CVDs.https://www.frontiersin.org/articles/10.3389/fcell.2021.788634/fullFUNDC1mitophagycardiovascular diseasesLC3MAM |
| spellingShingle | Guoyong Li Guoyong Li Guoyong Li Junli Li Ruochen Shao Ruochen Shao Ruochen Shao Jiahao Zhao Jiahao Zhao Mao Chen Mao Chen FUNDC1: A Promising Mitophagy Regulator at the Mitochondria-Associated Membrane for Cardiovascular Diseases Frontiers in Cell and Developmental Biology FUNDC1 mitophagy cardiovascular diseases LC3 MAM |
| title | FUNDC1: A Promising Mitophagy Regulator at the Mitochondria-Associated Membrane for Cardiovascular Diseases |
| title_full | FUNDC1: A Promising Mitophagy Regulator at the Mitochondria-Associated Membrane for Cardiovascular Diseases |
| title_fullStr | FUNDC1: A Promising Mitophagy Regulator at the Mitochondria-Associated Membrane for Cardiovascular Diseases |
| title_full_unstemmed | FUNDC1: A Promising Mitophagy Regulator at the Mitochondria-Associated Membrane for Cardiovascular Diseases |
| title_short | FUNDC1: A Promising Mitophagy Regulator at the Mitochondria-Associated Membrane for Cardiovascular Diseases |
| title_sort | fundc1 a promising mitophagy regulator at the mitochondria associated membrane for cardiovascular diseases |
| topic | FUNDC1 mitophagy cardiovascular diseases LC3 MAM |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2021.788634/full |
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