In Vitro Models Using the Human Placenta to Study Fetal Exposure to Drugs
Over the recent years there has been a gradual rise in the use of pharmaceuticals during pregnancy. Knowledge on placental drug transfer and metabolism has increased during the past decades as well. Investigation of the transplacental transfer of any therapeutically useful drug is essential to the u...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2008-01-01
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| Series: | Clinical Medicine Insights: Reproductive Health |
| Online Access: | https://doi.org/10.4137/CMRH.S974 |
| _version_ | 1819028175257075712 |
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| author | Michal Kovo M.D., Ph.D. Abraham Golan |
| author_facet | Michal Kovo M.D., Ph.D. Abraham Golan |
| author_sort | Michal Kovo M.D., Ph.D. |
| collection | DOAJ |
| description | Over the recent years there has been a gradual rise in the use of pharmaceuticals during pregnancy. Knowledge on placental drug transfer and metabolism has increased during the past decades as well. Investigation of the transplacental transfer of any therapeutically useful drug is essential to the understanding of its metabolic processes and is a prerequisite for its use during pregnancy. The purpose of this review is to give insight on the various techniques that have been developed to evaluate transplacental transfer of drugs and xenobiotics. |
| first_indexed | 2024-12-21T05:54:11Z |
| format | Article |
| id | doaj.art-81e2d1e85c164bca9b8f8a5f8a6125ae |
| institution | Directory Open Access Journal |
| issn | 1179-5581 |
| language | English |
| last_indexed | 2024-12-21T05:54:11Z |
| publishDate | 2008-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Clinical Medicine Insights: Reproductive Health |
| spelling | doaj.art-81e2d1e85c164bca9b8f8a5f8a6125ae2022-12-21T19:13:54ZengSAGE PublishingClinical Medicine Insights: Reproductive Health1179-55812008-01-01210.4137/CMRH.S974In Vitro Models Using the Human Placenta to Study Fetal Exposure to DrugsMichal Kovo M.D., Ph.D.0Abraham Golan1Department of Obstetrics and Gynecology, the E. Wolfson Medical Center, Holon, and Sackler School of Medicine, Tel Aviv University, Israel.Department of Obstetrics and Gynecology, the E. Wolfson Medical Center, Holon, and Sackler School of Medicine, Tel Aviv University, Israel.Over the recent years there has been a gradual rise in the use of pharmaceuticals during pregnancy. Knowledge on placental drug transfer and metabolism has increased during the past decades as well. Investigation of the transplacental transfer of any therapeutically useful drug is essential to the understanding of its metabolic processes and is a prerequisite for its use during pregnancy. The purpose of this review is to give insight on the various techniques that have been developed to evaluate transplacental transfer of drugs and xenobiotics.https://doi.org/10.4137/CMRH.S974 |
| spellingShingle | Michal Kovo M.D., Ph.D. Abraham Golan In Vitro Models Using the Human Placenta to Study Fetal Exposure to Drugs Clinical Medicine Insights: Reproductive Health |
| title | In Vitro Models Using the Human Placenta to Study Fetal Exposure to Drugs |
| title_full | In Vitro Models Using the Human Placenta to Study Fetal Exposure to Drugs |
| title_fullStr | In Vitro Models Using the Human Placenta to Study Fetal Exposure to Drugs |
| title_full_unstemmed | In Vitro Models Using the Human Placenta to Study Fetal Exposure to Drugs |
| title_short | In Vitro Models Using the Human Placenta to Study Fetal Exposure to Drugs |
| title_sort | in vitro models using the human placenta to study fetal exposure to drugs |
| url | https://doi.org/10.4137/CMRH.S974 |
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