The Effect of Fucoidan on the Pharmacokinetics of Letrozole and Tamoxifen in Patients With Breast Cancer
Background: Although the use of complementary and alternative medicines is widespread in cancer patients, clinical evidence of their benefits is sparse. Furthermore, while they are often assumed to be safe with regard to concurrent use of anticancer therapies, few studies have been carried out to in...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2018-03-01
|
| Series: | Integrative Cancer Therapies |
| Online Access: | https://doi.org/10.1177/1534735416684014 |
| _version_ | 1819292132962205696 |
|---|---|
| author | Shreya Tocaciu BDS, MBBS Lesley J. Oliver BAppSc Ray M. Lowenthal MD, FRACP Gregory M. Peterson PhD, MBA Rahul Patel PhD Madhur Shastri PhD Georgia McGuinness PhD Inger Olesen MBBS, FRACP J. Helen Fitton PhD |
| author_facet | Shreya Tocaciu BDS, MBBS Lesley J. Oliver BAppSc Ray M. Lowenthal MD, FRACP Gregory M. Peterson PhD, MBA Rahul Patel PhD Madhur Shastri PhD Georgia McGuinness PhD Inger Olesen MBBS, FRACP J. Helen Fitton PhD |
| author_sort | Shreya Tocaciu BDS, MBBS |
| collection | DOAJ |
| description | Background: Although the use of complementary and alternative medicines is widespread in cancer patients, clinical evidence of their benefits is sparse. Furthermore, while they are often assumed to be safe with regard to concurrent use of anticancer therapies, few studies have been carried out to investigate possible interactions. Fucoidans are a group of sulfated carbohydrates, derived from marine brown algae, which have long been used as dietary supplements due to their reported medicinal properties, including anticancer activity. The aim of this study was to investigate the effect of co-administration of fucoidan, derived from Undaria pinnatifida , on the pharmacokinetics of 2 commonly used hormonal therapies, letrozole and tamoxifen, in patients with breast cancer. Methods: This was an open label non-crossover study in patients with active malignancy taking letrozole or tamoxifen (n = 10 for each group). Patients took oral fucoidan, given in the form of Maritech extract, for a 3-week period (500 mg twice daily). Trough plasma concentrations of letrozole, tamoxifen, 4-hydroxytamoxifen, and endoxifen were measured using HPLC-CAD (high-performance liquid chromatography charged aerosol detector), at baseline and after concomitant administration with fucoidan. Results: No significant changes in steady-state plasma concentrations of letrozole, tamoxifen, or tamoxifen metabolites were detected after co-administration with fucoidan. In addition, no adverse effects of fucoidan were reported, and toxicity monitoring showed no significant differences in all parameters measured over the study period. Conclusions: Administration of Undaria pinnatifida fucoidan had no significant effect on the steady-state trough concentrations of letrozole or tamoxifen and was well tolerated. These results suggest that fucoidan in the studied form and dosage could be taken concomitantly with letrozole and tamoxifen without the risk of clinically significant interactions. |
| first_indexed | 2024-12-24T03:49:41Z |
| format | Article |
| id | doaj.art-81e4a3a993354e9b86aef5f35d3c7bb4 |
| institution | Directory Open Access Journal |
| issn | 1534-7354 1552-695X |
| language | English |
| last_indexed | 2024-12-24T03:49:41Z |
| publishDate | 2018-03-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Integrative Cancer Therapies |
| spelling | doaj.art-81e4a3a993354e9b86aef5f35d3c7bb42022-12-21T17:16:37ZengSAGE PublishingIntegrative Cancer Therapies1534-73541552-695X2018-03-011710.1177/1534735416684014The Effect of Fucoidan on the Pharmacokinetics of Letrozole and Tamoxifen in Patients With Breast CancerShreya Tocaciu BDS, MBBS0Lesley J. Oliver BAppSc1Ray M. Lowenthal MD, FRACP2Gregory M. Peterson PhD, MBA3Rahul Patel PhD4Madhur Shastri PhD5Georgia McGuinness PhD6Inger Olesen MBBS, FRACP7J. Helen Fitton PhD8Royal Hobart Hospital, Hobart, Tasmania, AustraliaRoyal Hobart Hospital, Hobart, Tasmania, AustraliaUniversity of Tasmania, Hobart, Tasmania, AustraliaUniversity of Tasmania, Hobart, Tasmania, AustraliaUniversity of Tasmania, Hobart, Tasmania, AustraliaUniversity of Tasmania, Hobart, Tasmania, AustraliaUniversity of Tasmania, Hobart, Tasmania, AustraliaAndrew Love Cancer Centre, Barwon Health, Geelong, Victoria, AustraliaMarinova Pty Ltd, Cambridge, Tasmania, AustraliaBackground: Although the use of complementary and alternative medicines is widespread in cancer patients, clinical evidence of their benefits is sparse. Furthermore, while they are often assumed to be safe with regard to concurrent use of anticancer therapies, few studies have been carried out to investigate possible interactions. Fucoidans are a group of sulfated carbohydrates, derived from marine brown algae, which have long been used as dietary supplements due to their reported medicinal properties, including anticancer activity. The aim of this study was to investigate the effect of co-administration of fucoidan, derived from Undaria pinnatifida , on the pharmacokinetics of 2 commonly used hormonal therapies, letrozole and tamoxifen, in patients with breast cancer. Methods: This was an open label non-crossover study in patients with active malignancy taking letrozole or tamoxifen (n = 10 for each group). Patients took oral fucoidan, given in the form of Maritech extract, for a 3-week period (500 mg twice daily). Trough plasma concentrations of letrozole, tamoxifen, 4-hydroxytamoxifen, and endoxifen were measured using HPLC-CAD (high-performance liquid chromatography charged aerosol detector), at baseline and after concomitant administration with fucoidan. Results: No significant changes in steady-state plasma concentrations of letrozole, tamoxifen, or tamoxifen metabolites were detected after co-administration with fucoidan. In addition, no adverse effects of fucoidan were reported, and toxicity monitoring showed no significant differences in all parameters measured over the study period. Conclusions: Administration of Undaria pinnatifida fucoidan had no significant effect on the steady-state trough concentrations of letrozole or tamoxifen and was well tolerated. These results suggest that fucoidan in the studied form and dosage could be taken concomitantly with letrozole and tamoxifen without the risk of clinically significant interactions.https://doi.org/10.1177/1534735416684014 |
| spellingShingle | Shreya Tocaciu BDS, MBBS Lesley J. Oliver BAppSc Ray M. Lowenthal MD, FRACP Gregory M. Peterson PhD, MBA Rahul Patel PhD Madhur Shastri PhD Georgia McGuinness PhD Inger Olesen MBBS, FRACP J. Helen Fitton PhD The Effect of Fucoidan on the Pharmacokinetics of Letrozole and Tamoxifen in Patients With Breast Cancer Integrative Cancer Therapies |
| title | The Effect of Fucoidan on the Pharmacokinetics of Letrozole and Tamoxifen in Patients With Breast Cancer |
| title_full | The Effect of Fucoidan on the Pharmacokinetics of Letrozole and Tamoxifen in Patients With Breast Cancer |
| title_fullStr | The Effect of Fucoidan on the Pharmacokinetics of Letrozole and Tamoxifen in Patients With Breast Cancer |
| title_full_unstemmed | The Effect of Fucoidan on the Pharmacokinetics of Letrozole and Tamoxifen in Patients With Breast Cancer |
| title_short | The Effect of Fucoidan on the Pharmacokinetics of Letrozole and Tamoxifen in Patients With Breast Cancer |
| title_sort | effect of fucoidan on the pharmacokinetics of letrozole and tamoxifen in patients with breast cancer |
| url | https://doi.org/10.1177/1534735416684014 |
| work_keys_str_mv | AT shreyatocaciubdsmbbs theeffectoffucoidanonthepharmacokineticsofletrozoleandtamoxifeninpatientswithbreastcancer AT lesleyjoliverbappsc theeffectoffucoidanonthepharmacokineticsofletrozoleandtamoxifeninpatientswithbreastcancer AT raymlowenthalmdfracp theeffectoffucoidanonthepharmacokineticsofletrozoleandtamoxifeninpatientswithbreastcancer AT gregorympetersonphdmba theeffectoffucoidanonthepharmacokineticsofletrozoleandtamoxifeninpatientswithbreastcancer AT rahulpatelphd theeffectoffucoidanonthepharmacokineticsofletrozoleandtamoxifeninpatientswithbreastcancer AT madhurshastriphd theeffectoffucoidanonthepharmacokineticsofletrozoleandtamoxifeninpatientswithbreastcancer AT georgiamcguinnessphd theeffectoffucoidanonthepharmacokineticsofletrozoleandtamoxifeninpatientswithbreastcancer AT ingerolesenmbbsfracp theeffectoffucoidanonthepharmacokineticsofletrozoleandtamoxifeninpatientswithbreastcancer AT jhelenfittonphd theeffectoffucoidanonthepharmacokineticsofletrozoleandtamoxifeninpatientswithbreastcancer AT shreyatocaciubdsmbbs effectoffucoidanonthepharmacokineticsofletrozoleandtamoxifeninpatientswithbreastcancer AT lesleyjoliverbappsc effectoffucoidanonthepharmacokineticsofletrozoleandtamoxifeninpatientswithbreastcancer AT raymlowenthalmdfracp effectoffucoidanonthepharmacokineticsofletrozoleandtamoxifeninpatientswithbreastcancer AT gregorympetersonphdmba effectoffucoidanonthepharmacokineticsofletrozoleandtamoxifeninpatientswithbreastcancer AT rahulpatelphd effectoffucoidanonthepharmacokineticsofletrozoleandtamoxifeninpatientswithbreastcancer AT madhurshastriphd effectoffucoidanonthepharmacokineticsofletrozoleandtamoxifeninpatientswithbreastcancer AT georgiamcguinnessphd effectoffucoidanonthepharmacokineticsofletrozoleandtamoxifeninpatientswithbreastcancer AT ingerolesenmbbsfracp effectoffucoidanonthepharmacokineticsofletrozoleandtamoxifeninpatientswithbreastcancer AT jhelenfittonphd effectoffucoidanonthepharmacokineticsofletrozoleandtamoxifeninpatientswithbreastcancer |