Intestinal barrier functions in hematologic and oncologic diseases
Abstract The intestinal barrier is a complex structure that not only regulates the influx of luminal contents into the systemic circulation but is also involved in immune, microbial, and metabolic homeostasis. Evidence implicating disruption in intestinal barrier functions in the development of many...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-03-01
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| Series: | Journal of Translational Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12967-023-04091-w |
| _version_ | 1797853592012455936 |
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| author | Elio Haroun Prashanth Ashok Kumar Ludovic Saba Joseph Kassab Krishna Ghimire Dibyendu Dutta Seah H. Lim |
| author_facet | Elio Haroun Prashanth Ashok Kumar Ludovic Saba Joseph Kassab Krishna Ghimire Dibyendu Dutta Seah H. Lim |
| author_sort | Elio Haroun |
| collection | DOAJ |
| description | Abstract The intestinal barrier is a complex structure that not only regulates the influx of luminal contents into the systemic circulation but is also involved in immune, microbial, and metabolic homeostasis. Evidence implicating disruption in intestinal barrier functions in the development of many systemic diseases, ranging from non-alcoholic steatohepatitis to autism, or systemic complications of intestinal disorders has increased rapidly in recent years, raising the possibility of the intestinal barrier as a potential target for therapeutic intervention to alter the course and mitigate the complications associated with these diseases. In addition to the disease process being associated with a breach in the intestinal barrier functions, patients with hematologic and oncologic diseases are particularly at high risks for the development of increased intestinal permeability, due to the frequent use of broad-spectrum antibiotics and chemoradiation. They also face a distinct challenge of being intermittently severely neutropenic due to treatment of the underlying conditions. In this review, we will discuss how hematologic and oncologic diseases are associated with disruption in the intestinal barrier and highlight the complications associated with an increase in the intestinal permeability. We will explore methods to modulate the complication. To provide a background for our discussion, we will first examine the structure and appraise the methods of evaluation of the intestinal barrier. |
| first_indexed | 2024-04-09T19:53:10Z |
| format | Article |
| id | doaj.art-81e4bea9821445ef9c6a82759fa14439 |
| institution | Directory Open Access Journal |
| issn | 1479-5876 |
| language | English |
| last_indexed | 2024-04-09T19:53:10Z |
| publishDate | 2023-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Translational Medicine |
| spelling | doaj.art-81e4bea9821445ef9c6a82759fa144392023-04-03T05:38:55ZengBMCJournal of Translational Medicine1479-58762023-03-0121111910.1186/s12967-023-04091-wIntestinal barrier functions in hematologic and oncologic diseasesElio Haroun0Prashanth Ashok Kumar1Ludovic Saba2Joseph Kassab3Krishna Ghimire4Dibyendu Dutta5Seah H. Lim6Division of Hematology and Oncology, State University of New York Upstate Medical University, SUNY Upstate Medical UniversityDivision of Hematology and Oncology, State University of New York Upstate Medical University, SUNY Upstate Medical UniversityDepartment of Medicine, Saint-Joseph University of BeirutDepartment of Medicine, Saint-Joseph University of BeirutDivision of Hematology and Oncology, State University of New York Upstate Medical University, SUNY Upstate Medical UniversityDivision of Hematology and Oncology, State University of New York Upstate Medical University, SUNY Upstate Medical UniversityDivision of Hematology and Oncology, State University of New York Upstate Medical University, SUNY Upstate Medical UniversityAbstract The intestinal barrier is a complex structure that not only regulates the influx of luminal contents into the systemic circulation but is also involved in immune, microbial, and metabolic homeostasis. Evidence implicating disruption in intestinal barrier functions in the development of many systemic diseases, ranging from non-alcoholic steatohepatitis to autism, or systemic complications of intestinal disorders has increased rapidly in recent years, raising the possibility of the intestinal barrier as a potential target for therapeutic intervention to alter the course and mitigate the complications associated with these diseases. In addition to the disease process being associated with a breach in the intestinal barrier functions, patients with hematologic and oncologic diseases are particularly at high risks for the development of increased intestinal permeability, due to the frequent use of broad-spectrum antibiotics and chemoradiation. They also face a distinct challenge of being intermittently severely neutropenic due to treatment of the underlying conditions. In this review, we will discuss how hematologic and oncologic diseases are associated with disruption in the intestinal barrier and highlight the complications associated with an increase in the intestinal permeability. We will explore methods to modulate the complication. To provide a background for our discussion, we will first examine the structure and appraise the methods of evaluation of the intestinal barrier.https://doi.org/10.1186/s12967-023-04091-wIntestinal barrierHematologicOncologicComplicationsPathogenesis |
| spellingShingle | Elio Haroun Prashanth Ashok Kumar Ludovic Saba Joseph Kassab Krishna Ghimire Dibyendu Dutta Seah H. Lim Intestinal barrier functions in hematologic and oncologic diseases Journal of Translational Medicine Intestinal barrier Hematologic Oncologic Complications Pathogenesis |
| title | Intestinal barrier functions in hematologic and oncologic diseases |
| title_full | Intestinal barrier functions in hematologic and oncologic diseases |
| title_fullStr | Intestinal barrier functions in hematologic and oncologic diseases |
| title_full_unstemmed | Intestinal barrier functions in hematologic and oncologic diseases |
| title_short | Intestinal barrier functions in hematologic and oncologic diseases |
| title_sort | intestinal barrier functions in hematologic and oncologic diseases |
| topic | Intestinal barrier Hematologic Oncologic Complications Pathogenesis |
| url | https://doi.org/10.1186/s12967-023-04091-w |
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