Long Non-Coding RNAs (lncRNAs) in Cardiovascular Disease Complication of Type 2 Diabetes
The discovery of non-coding RNAs (ncRNAs) has opened a new paradigm to use ncRNAs as biomarkers to detect disease progression. Long non-coding RNAs (lncRNA) have garnered the most attention due to their specific cell-origin and their existence in biological fluids. Type 2 diabetes patients will deve...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-01-01
|
| Series: | Diagnostics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2075-4418/11/1/145 |
| _version_ | 1827599582422368256 |
|---|---|
| author | Nurruzanna Ismail Noraidatulakma Abdullah Nor Azian Abdul Murad Rahman Jamal Siti Aishah Sulaiman |
| author_facet | Nurruzanna Ismail Noraidatulakma Abdullah Nor Azian Abdul Murad Rahman Jamal Siti Aishah Sulaiman |
| author_sort | Nurruzanna Ismail |
| collection | DOAJ |
| description | The discovery of non-coding RNAs (ncRNAs) has opened a new paradigm to use ncRNAs as biomarkers to detect disease progression. Long non-coding RNAs (lncRNA) have garnered the most attention due to their specific cell-origin and their existence in biological fluids. Type 2 diabetes patients will develop cardiovascular disease (CVD) complications, and CVD remains the top risk factor for mortality. Understanding the lncRNA roles in T2D and CVD conditions will allow the future use of lncRNAs to detect CVD complications before the symptoms appear. This review aimed to discuss the roles of lncRNAs in T2D and CVD conditions and their diagnostic potential as molecular biomarkers for CVD complications in T2D. |
| first_indexed | 2024-03-09T04:17:07Z |
| format | Article |
| id | doaj.art-81e5df4e9af34c9ebd1b144238b625f4 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-09T04:17:07Z |
| publishDate | 2021-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-81e5df4e9af34c9ebd1b144238b625f42023-12-03T13:51:39ZengMDPI AGDiagnostics2075-44182021-01-0111114510.3390/diagnostics11010145Long Non-Coding RNAs (lncRNAs) in Cardiovascular Disease Complication of Type 2 DiabetesNurruzanna Ismail0Noraidatulakma Abdullah1Nor Azian Abdul Murad2Rahman Jamal3Siti Aishah Sulaiman4UKM Medical Molecular Biology Institute (UMBI), Universiti Kebangsaan Malaysia, Jalan Yaa’cob Latiff, Cheras, Kuala Lumpur 56000, MalaysiaUKM Medical Molecular Biology Institute (UMBI), Universiti Kebangsaan Malaysia, Jalan Yaa’cob Latiff, Cheras, Kuala Lumpur 56000, MalaysiaUKM Medical Molecular Biology Institute (UMBI), Universiti Kebangsaan Malaysia, Jalan Yaa’cob Latiff, Cheras, Kuala Lumpur 56000, MalaysiaUKM Medical Molecular Biology Institute (UMBI), Universiti Kebangsaan Malaysia, Jalan Yaa’cob Latiff, Cheras, Kuala Lumpur 56000, MalaysiaUKM Medical Molecular Biology Institute (UMBI), Universiti Kebangsaan Malaysia, Jalan Yaa’cob Latiff, Cheras, Kuala Lumpur 56000, MalaysiaThe discovery of non-coding RNAs (ncRNAs) has opened a new paradigm to use ncRNAs as biomarkers to detect disease progression. Long non-coding RNAs (lncRNA) have garnered the most attention due to their specific cell-origin and their existence in biological fluids. Type 2 diabetes patients will develop cardiovascular disease (CVD) complications, and CVD remains the top risk factor for mortality. Understanding the lncRNA roles in T2D and CVD conditions will allow the future use of lncRNAs to detect CVD complications before the symptoms appear. This review aimed to discuss the roles of lncRNAs in T2D and CVD conditions and their diagnostic potential as molecular biomarkers for CVD complications in T2D.https://www.mdpi.com/2075-4418/11/1/145long noncoding RNAcardiovascular diseasetype 2 diabetesbiomarkerdiagnosisinsulin secretion |
| spellingShingle | Nurruzanna Ismail Noraidatulakma Abdullah Nor Azian Abdul Murad Rahman Jamal Siti Aishah Sulaiman Long Non-Coding RNAs (lncRNAs) in Cardiovascular Disease Complication of Type 2 Diabetes Diagnostics long noncoding RNA cardiovascular disease type 2 diabetes biomarker diagnosis insulin secretion |
| title | Long Non-Coding RNAs (lncRNAs) in Cardiovascular Disease Complication of Type 2 Diabetes |
| title_full | Long Non-Coding RNAs (lncRNAs) in Cardiovascular Disease Complication of Type 2 Diabetes |
| title_fullStr | Long Non-Coding RNAs (lncRNAs) in Cardiovascular Disease Complication of Type 2 Diabetes |
| title_full_unstemmed | Long Non-Coding RNAs (lncRNAs) in Cardiovascular Disease Complication of Type 2 Diabetes |
| title_short | Long Non-Coding RNAs (lncRNAs) in Cardiovascular Disease Complication of Type 2 Diabetes |
| title_sort | long non coding rnas lncrnas in cardiovascular disease complication of type 2 diabetes |
| topic | long noncoding RNA cardiovascular disease type 2 diabetes biomarker diagnosis insulin secretion |
| url | https://www.mdpi.com/2075-4418/11/1/145 |
| work_keys_str_mv | AT nurruzannaismail longnoncodingrnaslncrnasincardiovasculardiseasecomplicationoftype2diabetes AT noraidatulakmaabdullah longnoncodingrnaslncrnasincardiovasculardiseasecomplicationoftype2diabetes AT norazianabdulmurad longnoncodingrnaslncrnasincardiovasculardiseasecomplicationoftype2diabetes AT rahmanjamal longnoncodingrnaslncrnasincardiovasculardiseasecomplicationoftype2diabetes AT sitiaishahsulaiman longnoncodingrnaslncrnasincardiovasculardiseasecomplicationoftype2diabetes |