Serum Free Light-Chain Ratio at Diagnosis Is Associated with Early Renal Damage in Multiple Myeloma: A Case Series Real-World Study
The serum free light-chain (FLC) ratio is a sensitive tool for the differential diagnosis of plasma cell disorders and is biomarker of multiple myeloma (MM) progression from premalignant conditions. Here, we investigate the potential role of FLC ratio at diagnosis in identifying early renal damage i...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-07-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/10/7/1657 |
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| author | Danilo De Novellis Raffaele Fontana Angela Carobene Bianca Serio Idalucia Ferrara Maria Carmen Martorelli Laura Mettivier Roberto Guariglia Serena Luponio Immacolata Ruggiero Matteo D’Addona Tiziana Di Leo Valentina Giudice Carmine Selleri |
| author_facet | Danilo De Novellis Raffaele Fontana Angela Carobene Bianca Serio Idalucia Ferrara Maria Carmen Martorelli Laura Mettivier Roberto Guariglia Serena Luponio Immacolata Ruggiero Matteo D’Addona Tiziana Di Leo Valentina Giudice Carmine Selleri |
| author_sort | Danilo De Novellis |
| collection | DOAJ |
| description | The serum free light-chain (FLC) ratio is a sensitive tool for the differential diagnosis of plasma cell disorders and is biomarker of multiple myeloma (MM) progression from premalignant conditions. Here, we investigate the potential role of FLC ratio at diagnosis in identifying early renal damage in MM patients and other correlations with clinical, laboratory, and molecular findings. A total of 34 MM patients who had undergone autologous stem cell transplantation were included in this retrospective case series study, and FLC quantification was performed with nephelometric assays. In our study, sFLC ratio was significantly associated with light-chain MM and β-2 microglobulin levels, likely indicating a high disease burden at diagnosis, especially in patients without heavy chain M-protein at serum electrophoresis. Moreover, the sFLC ratio was inversely correlated with glomerular filtration rate, possibly identifying early renal damage in MM patients. Our preliminary results confirm the importance of early sFLC evaluation, especially in patients with the light-chain MM type and low disease burden, to minimize the risk of late renal failure. |
| first_indexed | 2024-03-09T10:22:21Z |
| format | Article |
| id | doaj.art-81e80c29661f4c71b230e117f5498a98 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-09T10:22:21Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-81e80c29661f4c71b230e117f5498a982023-12-01T21:56:13ZengMDPI AGBiomedicines2227-90592022-07-01107165710.3390/biomedicines10071657Serum Free Light-Chain Ratio at Diagnosis Is Associated with Early Renal Damage in Multiple Myeloma: A Case Series Real-World StudyDanilo De Novellis0Raffaele Fontana1Angela Carobene2Bianca Serio3Idalucia Ferrara4Maria Carmen Martorelli5Laura Mettivier6Roberto Guariglia7Serena Luponio8Immacolata Ruggiero9Matteo D’Addona10Tiziana Di Leo11Valentina Giudice12Carmine Selleri13Hematology and Transplant Center, University Hospital “San Giovanni di Dio e Ruggi d’Aragona”, 84131 Salerno, ItalyHematology and Transplant Center, University Hospital “San Giovanni di Dio e Ruggi d’Aragona”, 84131 Salerno, ItalyHematology and Transplant Center, University Hospital “San Giovanni di Dio e Ruggi d’Aragona”, 84131 Salerno, ItalyHematology and Transplant Center, University Hospital “San Giovanni di Dio e Ruggi d’Aragona”, 84131 Salerno, ItalyHematology and Transplant Center, University Hospital “San Giovanni di Dio e Ruggi d’Aragona”, 84131 Salerno, ItalyHematology and Transplant Center, University Hospital “San Giovanni di Dio e Ruggi d’Aragona”, 84131 Salerno, ItalyHematology and Transplant Center, University Hospital “San Giovanni di Dio e Ruggi d’Aragona”, 84131 Salerno, ItalyHematology and Transplant Center, University Hospital “San Giovanni di Dio e Ruggi d’Aragona”, 84131 Salerno, ItalyHematology and Transplant Center, University Hospital “San Giovanni di Dio e Ruggi d’Aragona”, 84131 Salerno, ItalyHematology and Transplant Center, University Hospital “San Giovanni di Dio e Ruggi d’Aragona”, 84131 Salerno, ItalyHematology and Transplant Center, University Hospital “San Giovanni di Dio e Ruggi d’Aragona”, 84131 Salerno, ItalyClinical Pathology and Biochemistry Unit, University Hospital “San Giovanni di Dio e Ruggi d’Aragona”, 84131 Salerno, ItalyHematology and Transplant Center, University Hospital “San Giovanni di Dio e Ruggi d’Aragona”, 84131 Salerno, ItalyHematology and Transplant Center, University Hospital “San Giovanni di Dio e Ruggi d’Aragona”, 84131 Salerno, ItalyThe serum free light-chain (FLC) ratio is a sensitive tool for the differential diagnosis of plasma cell disorders and is biomarker of multiple myeloma (MM) progression from premalignant conditions. Here, we investigate the potential role of FLC ratio at diagnosis in identifying early renal damage in MM patients and other correlations with clinical, laboratory, and molecular findings. A total of 34 MM patients who had undergone autologous stem cell transplantation were included in this retrospective case series study, and FLC quantification was performed with nephelometric assays. In our study, sFLC ratio was significantly associated with light-chain MM and β-2 microglobulin levels, likely indicating a high disease burden at diagnosis, especially in patients without heavy chain M-protein at serum electrophoresis. Moreover, the sFLC ratio was inversely correlated with glomerular filtration rate, possibly identifying early renal damage in MM patients. Our preliminary results confirm the importance of early sFLC evaluation, especially in patients with the light-chain MM type and low disease burden, to minimize the risk of late renal failure.https://www.mdpi.com/2227-9059/10/7/1657multiple myelomafree light-chain ratiorenal failureprognosisfree light chains |
| spellingShingle | Danilo De Novellis Raffaele Fontana Angela Carobene Bianca Serio Idalucia Ferrara Maria Carmen Martorelli Laura Mettivier Roberto Guariglia Serena Luponio Immacolata Ruggiero Matteo D’Addona Tiziana Di Leo Valentina Giudice Carmine Selleri Serum Free Light-Chain Ratio at Diagnosis Is Associated with Early Renal Damage in Multiple Myeloma: A Case Series Real-World Study Biomedicines multiple myeloma free light-chain ratio renal failure prognosis free light chains |
| title | Serum Free Light-Chain Ratio at Diagnosis Is Associated with Early Renal Damage in Multiple Myeloma: A Case Series Real-World Study |
| title_full | Serum Free Light-Chain Ratio at Diagnosis Is Associated with Early Renal Damage in Multiple Myeloma: A Case Series Real-World Study |
| title_fullStr | Serum Free Light-Chain Ratio at Diagnosis Is Associated with Early Renal Damage in Multiple Myeloma: A Case Series Real-World Study |
| title_full_unstemmed | Serum Free Light-Chain Ratio at Diagnosis Is Associated with Early Renal Damage in Multiple Myeloma: A Case Series Real-World Study |
| title_short | Serum Free Light-Chain Ratio at Diagnosis Is Associated with Early Renal Damage in Multiple Myeloma: A Case Series Real-World Study |
| title_sort | serum free light chain ratio at diagnosis is associated with early renal damage in multiple myeloma a case series real world study |
| topic | multiple myeloma free light-chain ratio renal failure prognosis free light chains |
| url | https://www.mdpi.com/2227-9059/10/7/1657 |
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