Beyond CTLA-4 and PD-1 Inhibition: Novel Immune Checkpoint Molecules for Melanoma Treatment

Beyond CTLA-4 and PD-1 Inhibition: Novel Immune Checkpoint Molecules for Melanoma Treatment

More than ten years after the approval of ipilimumab, immune checkpoint inhibitors (ICIs) against PD-1 and CTLA-4 have been established as the most effective treatment for locally advanced or metastatic melanoma, achieving durable responses either as monotherapies or in combinatorial regimens. Howev...

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Bibliographic Details
Main Authors: Dimitrios C. Ziogas, Charalampos Theocharopoulos, Panagiotis-Petros Lialios, Dimitra Foteinou, Ioannis-Alexios Koumprentziotis, Georgios Xynos, Helen Gogas
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:Cancers
Subjects:
immune checkpoints
immune checkpoint inhibitors
melanoma
immunotherapy resistance
relatlimab
LAG-3
Online Access:https://www.mdpi.com/2072-6694/15/10/2718

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