Research Priorities in the Secondary Prevention of Atrial Fibrillation: A National Heart, Lung, and Blood Institute Virtual Workshop Report
There has been sustained focus on the secondary prevention of coronary heart disease and heart failure; yet, apart from stroke prevention, the evidence base for the secondary prevention of atrial fibrillation (AF) recurrence, AF progression, and AF‐related complications is modest. Although there are...
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2021-08-01
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| Series: | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| Subjects: | |
| Online Access: | https://www.ahajournals.org/doi/10.1161/JAHA.121.021566 |
| _version_ | 1827932151844175872 |
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| author | Emelia J. Benjamin Sana M. Al‐Khatib Patrice Desvigne‐Nickens Alvaro Alonso Luc Djoussé Daniel E. Forman Anne M. Gillis Jeroen M. L. Hendriks Mellanie True Hills Paulus Kirchhof Mark S. Link Gregory M. Marcus Reena Mehra Katherine T. Murray Ratika Parkash Ileana L. Piña Susan Redline Michiel Rienstra Prashanthan Sanders Virend K. Somers David R. Van Wagoner Paul J. Wang Lawton S. Cooper Alan S. Go |
| author_facet | Emelia J. Benjamin Sana M. Al‐Khatib Patrice Desvigne‐Nickens Alvaro Alonso Luc Djoussé Daniel E. Forman Anne M. Gillis Jeroen M. L. Hendriks Mellanie True Hills Paulus Kirchhof Mark S. Link Gregory M. Marcus Reena Mehra Katherine T. Murray Ratika Parkash Ileana L. Piña Susan Redline Michiel Rienstra Prashanthan Sanders Virend K. Somers David R. Van Wagoner Paul J. Wang Lawton S. Cooper Alan S. Go |
| author_sort | Emelia J. Benjamin |
| collection | DOAJ |
| description | There has been sustained focus on the secondary prevention of coronary heart disease and heart failure; yet, apart from stroke prevention, the evidence base for the secondary prevention of atrial fibrillation (AF) recurrence, AF progression, and AF‐related complications is modest. Although there are multiple observational studies, there are few large, robust, randomized trials providing definitive effective approaches for the secondary prevention of AF. Given the increasing incidence and prevalence of AF nationally and internationally, the AF field needs transformative research and a commitment to evidenced‐based secondary prevention strategies. We report on a National Heart, Lung, and Blood Institute virtual workshop directed at identifying knowledge gaps and research opportunities in the secondary prevention of AF. Once AF has been detected, lifestyle changes and novel models of care delivery may contribute to the prevention of AF recurrence, AF progression, and AF‐related complications. Although benefits seen in small subgroups, cohort studies, and selected randomized trials are impressive, the widespread effectiveness of AF secondary prevention strategies remains unknown, calling for development of scalable interventions suitable for diverse populations and for identification of subpopulations who may particularly benefit from intensive management. We identified critical research questions for 6 topics relevant to the secondary prevention of AF: (1) weight loss; (2) alcohol intake, smoking cessation, and diet; (3) cardiac rehabilitation; (4) approaches to sleep disorders; (5) integrated, team‐based care; and (6) nonanticoagulant pharmacotherapy. Our goal is to stimulate innovative research that will accelerate the generation of the evidence to effectively pursue the secondary prevention of AF. |
| first_indexed | 2024-03-13T07:05:31Z |
| format | Article |
| id | doaj.art-81ea7a057e25430d9df323410abcf3f6 |
| institution | Directory Open Access Journal |
| issn | 2047-9980 |
| language | English |
| last_indexed | 2024-03-13T07:05:31Z |
| publishDate | 2021-08-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| spelling | doaj.art-81ea7a057e25430d9df323410abcf3f62023-06-06T12:10:52ZengWileyJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease2047-99802021-08-01101610.1161/JAHA.121.021566Research Priorities in the Secondary Prevention of Atrial Fibrillation: A National Heart, Lung, and Blood Institute Virtual Workshop ReportEmelia J. Benjamin0Sana M. Al‐Khatib1Patrice Desvigne‐Nickens2Alvaro Alonso3Luc Djoussé4Daniel E. Forman5Anne M. Gillis6Jeroen M. L. Hendriks7Mellanie True Hills8Paulus Kirchhof9Mark S. Link10Gregory M. Marcus11Reena Mehra12Katherine T. Murray13Ratika Parkash14Ileana L. Piña15Susan Redline16Michiel Rienstra17Prashanthan Sanders18Virend K. Somers19David R. Van Wagoner20Paul J. Wang21Lawton S. Cooper22Alan S. Go23Cardiovascular Medicine Department of Medicine Boston University School of Medicine Boston MADivision of Cardiology and Duke Clinical Research Institute Duke University Medical Center Durham NCDivision of Cardiovascular Sciences National Heart, Lung, and Blood InstituteNational Institutes of Health Bethesda MDDepartment of Epidemiology Rollins School of Public Health Emory University Atlanta GADivision of Aging Department of Medicine Brigham and Women’s Hospital and Harvard Medical School Boston MADivisions of Geriatrics and Cardiology University of Pittsburgh Medical CenterAging InstituteUniversity of PittsburghVA Pittsburgh Healthcare System Pittsburgh PALibin Cardiovascular Institute of AlbertaUniversity of Calgary Alberta CanadaCentre for Heart Rhythm Disorders University of Adelaide, and Royal Adelaide Hospital Adelaide AustraliaStopAfib.org American Foundation for Women’s Health Decatur TXDepartment of Cardiology University Heart and Vascular Center UKE Hamburg Hamburg GermanyDivision of Cardiology Department of Medicine UT Southwestern Medical Center Dallas TXDivision of Cardiology University of California, San Francisco San Francisco CASleep Disorders Center Neurologic Institute Respiratory Institute Heart and Vascular Institute, and Molecular Cardiology Department of the Lerner Research Institute Cleveland Clinic Cleveland OHVanderbilt University School of Medicine Nashville TNDivision of Cardiology QEII Health Sciences Center/Dalhousie University Halifax Nova Scotia CanadaWayne State University Detroit MIDepartment of Medicine Brigham and Women’s Hospital Boston MADepartment of Cardiology University of GroningenUniversity Medical Center Groningen Groningen the NetherlandsCentre for Heart Rhythm Disorders University of Adelaide, and Royal Adelaide Hospital Adelaide AustraliaDepartment of Cardiovascular Medicine Mayo Clinic Rochester MNCleveland Clinic Lerner College of Medicine Cleveland OHStanford University School of Medicine Palo Alto CADivision of Cardiovascular Sciences National Heart, Lung, and Blood InstituteNational Institutes of Health Bethesda MDDivision of Research Kaiser Permanente Northern California Oakland CAThere has been sustained focus on the secondary prevention of coronary heart disease and heart failure; yet, apart from stroke prevention, the evidence base for the secondary prevention of atrial fibrillation (AF) recurrence, AF progression, and AF‐related complications is modest. Although there are multiple observational studies, there are few large, robust, randomized trials providing definitive effective approaches for the secondary prevention of AF. Given the increasing incidence and prevalence of AF nationally and internationally, the AF field needs transformative research and a commitment to evidenced‐based secondary prevention strategies. We report on a National Heart, Lung, and Blood Institute virtual workshop directed at identifying knowledge gaps and research opportunities in the secondary prevention of AF. Once AF has been detected, lifestyle changes and novel models of care delivery may contribute to the prevention of AF recurrence, AF progression, and AF‐related complications. Although benefits seen in small subgroups, cohort studies, and selected randomized trials are impressive, the widespread effectiveness of AF secondary prevention strategies remains unknown, calling for development of scalable interventions suitable for diverse populations and for identification of subpopulations who may particularly benefit from intensive management. We identified critical research questions for 6 topics relevant to the secondary prevention of AF: (1) weight loss; (2) alcohol intake, smoking cessation, and diet; (3) cardiac rehabilitation; (4) approaches to sleep disorders; (5) integrated, team‐based care; and (6) nonanticoagulant pharmacotherapy. Our goal is to stimulate innovative research that will accelerate the generation of the evidence to effectively pursue the secondary prevention of AF.https://www.ahajournals.org/doi/10.1161/JAHA.121.021566atrial fibrillationcardiac rehabilitationpreventionresearchrisk factorssleep |
| spellingShingle | Emelia J. Benjamin Sana M. Al‐Khatib Patrice Desvigne‐Nickens Alvaro Alonso Luc Djoussé Daniel E. Forman Anne M. Gillis Jeroen M. L. Hendriks Mellanie True Hills Paulus Kirchhof Mark S. Link Gregory M. Marcus Reena Mehra Katherine T. Murray Ratika Parkash Ileana L. Piña Susan Redline Michiel Rienstra Prashanthan Sanders Virend K. Somers David R. Van Wagoner Paul J. Wang Lawton S. Cooper Alan S. Go Research Priorities in the Secondary Prevention of Atrial Fibrillation: A National Heart, Lung, and Blood Institute Virtual Workshop Report Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease atrial fibrillation cardiac rehabilitation prevention research risk factors sleep |
| title | Research Priorities in the Secondary Prevention of Atrial Fibrillation: A National Heart, Lung, and Blood Institute Virtual Workshop Report |
| title_full | Research Priorities in the Secondary Prevention of Atrial Fibrillation: A National Heart, Lung, and Blood Institute Virtual Workshop Report |
| title_fullStr | Research Priorities in the Secondary Prevention of Atrial Fibrillation: A National Heart, Lung, and Blood Institute Virtual Workshop Report |
| title_full_unstemmed | Research Priorities in the Secondary Prevention of Atrial Fibrillation: A National Heart, Lung, and Blood Institute Virtual Workshop Report |
| title_short | Research Priorities in the Secondary Prevention of Atrial Fibrillation: A National Heart, Lung, and Blood Institute Virtual Workshop Report |
| title_sort | research priorities in the secondary prevention of atrial fibrillation a national heart lung and blood institute virtual workshop report |
| topic | atrial fibrillation cardiac rehabilitation prevention research risk factors sleep |
| url | https://www.ahajournals.org/doi/10.1161/JAHA.121.021566 |
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