Prevalence and Prognostic Factors of Stress Hyperglycemia in a Pediatric Population with Acute Illness in Greece—A Prospective Observational Study
Background: stress hyperglycemia (SH) is a relatively frequent finding in pediatric patients. The purpose of this prospective observational study was to identify the prevalence of pediatric SH and its associated risk factors in Greece. Methods: A total of 1005 patients without diabetes who were admi...
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| Format: | Article |
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MDPI AG
2022-02-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/11/5/1301 |
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| author | Emmanouil Korakas Theodoros Argyropoulos Georgia-Angeliki Koliou Aristofanis Gikas Aikaterini Kountouri Stavroula Kostaridou Nikolopoulou Panagiotis Plotas Konstantinos Kontoangelos Ignatios Ikonomidis Nikolaos P. E. Kadoglou Athanasios Raptis Vaia Lambadiari |
| author_facet | Emmanouil Korakas Theodoros Argyropoulos Georgia-Angeliki Koliou Aristofanis Gikas Aikaterini Kountouri Stavroula Kostaridou Nikolopoulou Panagiotis Plotas Konstantinos Kontoangelos Ignatios Ikonomidis Nikolaos P. E. Kadoglou Athanasios Raptis Vaia Lambadiari |
| author_sort | Emmanouil Korakas |
| collection | DOAJ |
| description | Background: stress hyperglycemia (SH) is a relatively frequent finding in pediatric patients. The purpose of this prospective observational study was to identify the prevalence of pediatric SH and its associated risk factors in Greece. Methods: A total of 1005 patients without diabetes who were admitted consecutively for acute illness in a Pediatric Emergency Department were included in the study. Medical history, anthropometric measurements, blood glucose levels, and the medication administered were recorded. A questionnaire was distributed to parents regarding medical and perinatal history and sociodemographic characteristics. Results: There were 72 cases of SH on admission (7.2%) and 39 (3.9%) during hospitalization. Mean age was 6.4 years; 50.3% were male. SH on admission was associated with oral corticosteroid therapy (21.1% vs. 4.7%, <i>p</i> < 0.001), inhaled corticosteroids (12.7% vs. 3%, <i>p</i> < 0.001), and inhaled β2-agonists (30.6% vs. 10.7%, <i>p</i> < 0.001). In-hospital hyperglycemia was associated with oral corticosteroids (adjusted OR = 3.32), inhaled corticosteroids (OR = 10.03) and inhaled β2-agonists (OR = 5.01). Children with asthma were 5.58 and 7.86 times more likely to present admission and in-hospital hyperglycemia, respectively. Conclusions: This is the first report of SH prevalence in pediatric patients in Greece. Asthma, corticosteroids, and β2-agonists significantly increase the risk of SH. No parental factors seem to predispose to SH. |
| first_indexed | 2024-03-09T20:35:03Z |
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| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-09T20:35:03Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
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| series | Journal of Clinical Medicine |
| spelling | doaj.art-81ecec141acb405ea79fd12dbc6ac9a62023-11-23T23:13:50ZengMDPI AGJournal of Clinical Medicine2077-03832022-02-01115130110.3390/jcm11051301Prevalence and Prognostic Factors of Stress Hyperglycemia in a Pediatric Population with Acute Illness in Greece—A Prospective Observational StudyEmmanouil Korakas0Theodoros Argyropoulos1Georgia-Angeliki Koliou2Aristofanis Gikas3Aikaterini Kountouri4Stavroula Kostaridou Nikolopoulou5Panagiotis Plotas6Konstantinos Kontoangelos7Ignatios Ikonomidis8Nikolaos P. E. Kadoglou9Athanasios Raptis10Vaia Lambadiari11Second Department of Internal Medicine and Research Institute, Attikon University Hospital, Medical School, National and Kapodistrian University of Athens, 12462 Athens, GreeceDepartment of Paediatrics, Penteli Children’s Hospital, 15236 Athens, GreeceSecond Department of Internal Medicine and Research Institute, Attikon University Hospital, Medical School, National and Kapodistrian University of Athens, 12462 Athens, GreeceHealth Center of Kalivia, 19010 Athens, GreeceSecond Department of Internal Medicine and Research Institute, Attikon University Hospital, Medical School, National and Kapodistrian University of Athens, 12462 Athens, GreeceDepartment of Paediatrics, Penteli Children’s Hospital, 15236 Athens, GreeceDepartment of Cardiology, University of Patras Medical School, 26504 Patras, GreeceFirst Department of Psychiatry, Eginition Hospital, Medical School, National and Kapodistrian University of Athens, 11528 Athens, GreeceSecond Cardiology Department, Attikon University Hospital, Medical School, National and Kapodistrian University of Athens, 12462 Athens, GreeceMedical School, University of Cyprus, Nicosia 1678, CyprusSecond Department of Internal Medicine and Research Institute, Attikon University Hospital, Medical School, National and Kapodistrian University of Athens, 12462 Athens, GreeceSecond Department of Internal Medicine and Research Institute, Attikon University Hospital, Medical School, National and Kapodistrian University of Athens, 12462 Athens, GreeceBackground: stress hyperglycemia (SH) is a relatively frequent finding in pediatric patients. The purpose of this prospective observational study was to identify the prevalence of pediatric SH and its associated risk factors in Greece. Methods: A total of 1005 patients without diabetes who were admitted consecutively for acute illness in a Pediatric Emergency Department were included in the study. Medical history, anthropometric measurements, blood glucose levels, and the medication administered were recorded. A questionnaire was distributed to parents regarding medical and perinatal history and sociodemographic characteristics. Results: There were 72 cases of SH on admission (7.2%) and 39 (3.9%) during hospitalization. Mean age was 6.4 years; 50.3% were male. SH on admission was associated with oral corticosteroid therapy (21.1% vs. 4.7%, <i>p</i> < 0.001), inhaled corticosteroids (12.7% vs. 3%, <i>p</i> < 0.001), and inhaled β2-agonists (30.6% vs. 10.7%, <i>p</i> < 0.001). In-hospital hyperglycemia was associated with oral corticosteroids (adjusted OR = 3.32), inhaled corticosteroids (OR = 10.03) and inhaled β2-agonists (OR = 5.01). Children with asthma were 5.58 and 7.86 times more likely to present admission and in-hospital hyperglycemia, respectively. Conclusions: This is the first report of SH prevalence in pediatric patients in Greece. Asthma, corticosteroids, and β2-agonists significantly increase the risk of SH. No parental factors seem to predispose to SH.https://www.mdpi.com/2077-0383/11/5/1301stress hyperglycemiaasthmacorticosteroidsβ2-agonistspediatric |
| spellingShingle | Emmanouil Korakas Theodoros Argyropoulos Georgia-Angeliki Koliou Aristofanis Gikas Aikaterini Kountouri Stavroula Kostaridou Nikolopoulou Panagiotis Plotas Konstantinos Kontoangelos Ignatios Ikonomidis Nikolaos P. E. Kadoglou Athanasios Raptis Vaia Lambadiari Prevalence and Prognostic Factors of Stress Hyperglycemia in a Pediatric Population with Acute Illness in Greece—A Prospective Observational Study Journal of Clinical Medicine stress hyperglycemia asthma corticosteroids β2-agonists pediatric |
| title | Prevalence and Prognostic Factors of Stress Hyperglycemia in a Pediatric Population with Acute Illness in Greece—A Prospective Observational Study |
| title_full | Prevalence and Prognostic Factors of Stress Hyperglycemia in a Pediatric Population with Acute Illness in Greece—A Prospective Observational Study |
| title_fullStr | Prevalence and Prognostic Factors of Stress Hyperglycemia in a Pediatric Population with Acute Illness in Greece—A Prospective Observational Study |
| title_full_unstemmed | Prevalence and Prognostic Factors of Stress Hyperglycemia in a Pediatric Population with Acute Illness in Greece—A Prospective Observational Study |
| title_short | Prevalence and Prognostic Factors of Stress Hyperglycemia in a Pediatric Population with Acute Illness in Greece—A Prospective Observational Study |
| title_sort | prevalence and prognostic factors of stress hyperglycemia in a pediatric population with acute illness in greece a prospective observational study |
| topic | stress hyperglycemia asthma corticosteroids β2-agonists pediatric |
| url | https://www.mdpi.com/2077-0383/11/5/1301 |
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