Effects of twenty kinds of chemotherapeutic agents on the proliferation of Treg cells
Objective To observe the effects of 20 chemotherapeutic agents on the proliferation of Treg cells. Methods Twenty agents used in routine chemotherapy were selected and assayed on IL-2- induced Treg cell proliferation through CellTrace labeling and flow cytometry. Results After treatme...
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | zho |
| Published: |
Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College.
2023-10-01
|
| Series: | Jichu yixue yu linchuang |
| Subjects: | |
| Online Access: | http://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/1001-6325-2023-43-10-1518.pdf |
| _version_ | 1797361373225680896 |
|---|---|
| author | HUANG Wei, LING Ruiyun, GAO Lexin, TANG Wen, QIAN Lingbo, CHEN Fengyang |
| author_facet | HUANG Wei, LING Ruiyun, GAO Lexin, TANG Wen, QIAN Lingbo, CHEN Fengyang |
| author_sort | HUANG Wei, LING Ruiyun, GAO Lexin, TANG Wen, QIAN Lingbo, CHEN Fengyang |
| collection | DOAJ |
| description | Objective To observe the effects of 20 chemotherapeutic agents on the proliferation of Treg cells. Methods Twenty agents used in routine chemotherapy were selected and assayed on IL-2- induced Treg cell proliferation through CellTrace labeling and flow cytometry. Results After treatment with 12 chemotherapeutic agents at non-cytotoxic concentration, the proportion as well as the number of Foxp3+Treg cells in CD4+ T cells were significantly reduced. Conclusions Twelve chemotherapeutic agents including 3 tubulin interfering agents, 3 transcription and RNA synthesis interfering agents and 2 topoisomerase inhibitors inhibited the proliferation of Treg cells. |
| first_indexed | 2024-03-08T15:53:44Z |
| format | Article |
| id | doaj.art-81ed925a0ccf43a2af0ecd5d2aedf823 |
| institution | Directory Open Access Journal |
| issn | 1001-6325 |
| language | zho |
| last_indexed | 2024-03-08T15:53:44Z |
| publishDate | 2023-10-01 |
| publisher | Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College. |
| record_format | Article |
| series | Jichu yixue yu linchuang |
| spelling | doaj.art-81ed925a0ccf43a2af0ecd5d2aedf8232024-01-09T03:15:35ZzhoInstitute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College.Jichu yixue yu linchuang1001-63252023-10-0143101518152110.16352/j.issn.1001-6325.2023.10.1518Effects of twenty kinds of chemotherapeutic agents on the proliferation of Treg cellsHUANG Wei, LING Ruiyun, GAO Lexin, TANG Wen, QIAN Lingbo, CHEN Fengyang0School of Basic Medical Sciences & Forensic Medicine, Hangzhou Medical College, Hangzhou 310053, ChinaObjective To observe the effects of 20 chemotherapeutic agents on the proliferation of Treg cells. Methods Twenty agents used in routine chemotherapy were selected and assayed on IL-2- induced Treg cell proliferation through CellTrace labeling and flow cytometry. Results After treatment with 12 chemotherapeutic agents at non-cytotoxic concentration, the proportion as well as the number of Foxp3+Treg cells in CD4+ T cells were significantly reduced. Conclusions Twelve chemotherapeutic agents including 3 tubulin interfering agents, 3 transcription and RNA synthesis interfering agents and 2 topoisomerase inhibitors inhibited the proliferation of Treg cells.http://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/1001-6325-2023-43-10-1518.pdfcancer immunity|chemotherapy|treg cell |
| spellingShingle | HUANG Wei, LING Ruiyun, GAO Lexin, TANG Wen, QIAN Lingbo, CHEN Fengyang Effects of twenty kinds of chemotherapeutic agents on the proliferation of Treg cells Jichu yixue yu linchuang cancer immunity|chemotherapy|treg cell |
| title | Effects of twenty kinds of chemotherapeutic agents on the proliferation of Treg cells |
| title_full | Effects of twenty kinds of chemotherapeutic agents on the proliferation of Treg cells |
| title_fullStr | Effects of twenty kinds of chemotherapeutic agents on the proliferation of Treg cells |
| title_full_unstemmed | Effects of twenty kinds of chemotherapeutic agents on the proliferation of Treg cells |
| title_short | Effects of twenty kinds of chemotherapeutic agents on the proliferation of Treg cells |
| title_sort | effects of twenty kinds of chemotherapeutic agents on the proliferation of treg cells |
| topic | cancer immunity|chemotherapy|treg cell |
| url | http://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/1001-6325-2023-43-10-1518.pdf |
| work_keys_str_mv | AT huangweilingruiyungaolexintangwenqianlingbochenfengyang effectsoftwentykindsofchemotherapeuticagentsontheproliferationoftregcells |