RnlB Antitoxin of the Escherichia coli RnlA-RnlB Toxin–Antitoxin Module Requires RNase HI for Inhibition of RnlA Toxin Activity

RnlB Antitoxin of the Escherichia coli RnlA-RnlB Toxin–Antitoxin Module Requires RNase HI for Inhibition of RnlA Toxin Activity

The Escherichia coli RnlA-RnlB toxin–antitoxin system is related to the anti-phage mechanism. Under normal growth conditions, an RnlA toxin with endoribonuclease activity is inhibited by binding of its cognate RnlB antitoxin. After bacteriophage T4 infection, RnlA is activated by the disappearance o...

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Bibliographic Details
Main Authors: Kenta Naka, Dan Qi, Tetsuro Yonesaki, Yuichi Otsuka
Format: Article
Language:English
Published: MDPI AG 2017-01-01
Series:Toxins
Subjects:
toxin–antitoxin system
RnlA-RnlB
RNase HI
Escherichia coli
bacteriophage
Online Access:http://www.mdpi.com/2072-6651/9/1/29

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