Circular RNAs: biogenesis, expression and their potential roles in reproduction
Abstract Unlike other non-coding RNAs (ncRNAs), circular RNA (circRNA) is generally presented as a covalently linked circle lacking both a 5′ cap and a 3′ tail. circRNAs were thought to be spliced intermediates, byproducts, or products of abnormal RNA splicing events. However, the high-throughput se...
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| Format: | Article |
| Language: | English |
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BMC
2018-01-01
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| Series: | Journal of Ovarian Research |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13048-018-0381-4 |
| _version_ | 1828080779047993344 |
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| author | Guobo Quan Julang Li |
| author_facet | Guobo Quan Julang Li |
| author_sort | Guobo Quan |
| collection | DOAJ |
| description | Abstract Unlike other non-coding RNAs (ncRNAs), circular RNA (circRNA) is generally presented as a covalently linked circle lacking both a 5′ cap and a 3′ tail. circRNAs were thought to be spliced intermediates, byproducts, or products of abnormal RNA splicing events. However, the high-throughput sequencing technology coupled with bioinformatics has recently uncovered thousands of endogenous circRNAs in cells of many different species. These circRNAs show various features, such as abundant expression, evolutionary conservation, cell- or tissue-specific expression, and a higher resistance to degradation caused by exonuclease or ribonuclease (RNase), suggesting their potentially biological significance. However, the function of these circRNAs, their mechanism of action, and the regulation of their biogenesis and degradation remains largely unclear. The current research and findings of circRNA in the context of reproduction will be reviewed. Additionally, the perspectives of circRNAs in the field will be discussed. |
| first_indexed | 2024-04-11T03:24:46Z |
| format | Article |
| id | doaj.art-81ef96f6ab6e4d5aaa3ca8fb841a21c2 |
| institution | Directory Open Access Journal |
| issn | 1757-2215 |
| language | English |
| last_indexed | 2024-04-11T03:24:46Z |
| publishDate | 2018-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Ovarian Research |
| spelling | doaj.art-81ef96f6ab6e4d5aaa3ca8fb841a21c22023-01-02T07:51:33ZengBMCJournal of Ovarian Research1757-22152018-01-0111111210.1186/s13048-018-0381-4Circular RNAs: biogenesis, expression and their potential roles in reproductionGuobo Quan0Julang Li1Yunnan Animal Science and Veterinary Institute, Jindian, Panlong countyDepartment of Animal Biosciences, University of GuelphAbstract Unlike other non-coding RNAs (ncRNAs), circular RNA (circRNA) is generally presented as a covalently linked circle lacking both a 5′ cap and a 3′ tail. circRNAs were thought to be spliced intermediates, byproducts, or products of abnormal RNA splicing events. However, the high-throughput sequencing technology coupled with bioinformatics has recently uncovered thousands of endogenous circRNAs in cells of many different species. These circRNAs show various features, such as abundant expression, evolutionary conservation, cell- or tissue-specific expression, and a higher resistance to degradation caused by exonuclease or ribonuclease (RNase), suggesting their potentially biological significance. However, the function of these circRNAs, their mechanism of action, and the regulation of their biogenesis and degradation remains largely unclear. The current research and findings of circRNA in the context of reproduction will be reviewed. Additionally, the perspectives of circRNAs in the field will be discussed.http://link.springer.com/article/10.1186/s13048-018-0381-4Circular RNAReproductionGene regulationmiRNAlncRNA |
| spellingShingle | Guobo Quan Julang Li Circular RNAs: biogenesis, expression and their potential roles in reproduction Journal of Ovarian Research Circular RNA Reproduction Gene regulation miRNA lncRNA |
| title | Circular RNAs: biogenesis, expression and their potential roles in reproduction |
| title_full | Circular RNAs: biogenesis, expression and their potential roles in reproduction |
| title_fullStr | Circular RNAs: biogenesis, expression and their potential roles in reproduction |
| title_full_unstemmed | Circular RNAs: biogenesis, expression and their potential roles in reproduction |
| title_short | Circular RNAs: biogenesis, expression and their potential roles in reproduction |
| title_sort | circular rnas biogenesis expression and their potential roles in reproduction |
| topic | Circular RNA Reproduction Gene regulation miRNA lncRNA |
| url | http://link.springer.com/article/10.1186/s13048-018-0381-4 |
| work_keys_str_mv | AT guoboquan circularrnasbiogenesisexpressionandtheirpotentialrolesinreproduction AT julangli circularrnasbiogenesisexpressionandtheirpotentialrolesinreproduction |