Recent Progress in in vitro Models for Atherosclerosis Studies
Atherosclerosis is the primary cause of hardening and narrowing arteries, leading to cardiovascular disease accounting for the high mortality in the United States. For developing effective treatments for atherosclerosis, considerable efforts have been devoted to developing in vitro models. Compared...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-01-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2021.790529/full |
| _version_ | 1828893466473529344 |
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| author | Jun Chen Xixi Zhang Reid Millican Tyler Lynd Manas Gangasani Shubh Malhotra Jennifer Sherwood Patrick Taejoon Hwang Younghye Cho Younghye Cho Brigitta C. Brott Brigitta C. Brott Brigitta C. Brott Gangjian Qin Hanjoong Jo Young-sup Yoon Young-sup Yoon Ho-Wook Jun Ho-Wook Jun |
| author_facet | Jun Chen Xixi Zhang Reid Millican Tyler Lynd Manas Gangasani Shubh Malhotra Jennifer Sherwood Patrick Taejoon Hwang Younghye Cho Younghye Cho Brigitta C. Brott Brigitta C. Brott Brigitta C. Brott Gangjian Qin Hanjoong Jo Young-sup Yoon Young-sup Yoon Ho-Wook Jun Ho-Wook Jun |
| author_sort | Jun Chen |
| collection | DOAJ |
| description | Atherosclerosis is the primary cause of hardening and narrowing arteries, leading to cardiovascular disease accounting for the high mortality in the United States. For developing effective treatments for atherosclerosis, considerable efforts have been devoted to developing in vitro models. Compared to animal models, in vitro models can provide great opportunities to obtain data more efficiently, economically. Therefore, this review discusses the recent progress in in vitro models for atherosclerosis studies, including traditional two-dimensional (2D) systems cultured on the tissue culture plate, 2D cell sheets, and recently emerged microfluidic chip models with 2D culture. In addition, advanced in vitro three-dimensional models such as spheroids, cell-laden hydrogel constructs, tissue-engineered blood vessels, and vessel-on-a-chip will also be covered. Moreover, the functions of these models are also summarized along with model discussion. Lastly, the future perspectives of this field are discussed. |
| first_indexed | 2024-12-13T13:54:12Z |
| format | Article |
| id | doaj.art-81ef9724664643c39ed92ec2e85c3f52 |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-12-13T13:54:12Z |
| publishDate | 2022-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-81ef9724664643c39ed92ec2e85c3f522022-12-21T23:42:58ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2022-01-01810.3389/fcvm.2021.790529790529Recent Progress in in vitro Models for Atherosclerosis StudiesJun Chen0Xixi Zhang1Reid Millican2Tyler Lynd3Manas Gangasani4Shubh Malhotra5Jennifer Sherwood6Patrick Taejoon Hwang7Younghye Cho8Younghye Cho9Brigitta C. Brott10Brigitta C. Brott11Brigitta C. Brott12Gangjian Qin13Hanjoong Jo14Young-sup Yoon15Young-sup Yoon16Ho-Wook Jun17Ho-Wook Jun18Department of Biomedical Engineering, The University of Alabama at Birmingham, Birmingham, AL, United StatesDepartment of Biomedical Engineering, The University of Alabama at Birmingham, Birmingham, AL, United StatesEndomimetics, LLC., Birmingham, AL, United StatesDepartment of Biomedical Engineering, The University of Alabama at Birmingham, Birmingham, AL, United StatesDepartment of Biomedical Engineering, The University of Alabama at Birmingham, Birmingham, AL, United StatesDepartment of Biomedical Engineering, The University of Alabama at Birmingham, Birmingham, AL, United StatesEndomimetics, LLC., Birmingham, AL, United StatesEndomimetics, LLC., Birmingham, AL, United StatesDepartment of Biomedical Engineering, The University of Alabama at Birmingham, Birmingham, AL, United StatesFamily Medicine Clinic, Obesity, Metabolism, and Nutrition Center and Research Institute of Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, South KoreaDepartment of Biomedical Engineering, The University of Alabama at Birmingham, Birmingham, AL, United StatesEndomimetics, LLC., Birmingham, AL, United StatesDivision of Cardiovascular Disease, School of Medicine, The University of Alabama at Birmingham, Birmingham, AL, United StatesDepartment of Biomedical Engineering, The University of Alabama at Birmingham, Birmingham, AL, United StatesWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, United StatesDivision of Cardiology, Department of Medicine, Emory University, Atlanta, GA, United StatesSeverance Biomedical Science Institute, Yonsei University College of Medicine, Seoul, South KoreaDepartment of Biomedical Engineering, The University of Alabama at Birmingham, Birmingham, AL, United StatesEndomimetics, LLC., Birmingham, AL, United StatesAtherosclerosis is the primary cause of hardening and narrowing arteries, leading to cardiovascular disease accounting for the high mortality in the United States. For developing effective treatments for atherosclerosis, considerable efforts have been devoted to developing in vitro models. Compared to animal models, in vitro models can provide great opportunities to obtain data more efficiently, economically. Therefore, this review discusses the recent progress in in vitro models for atherosclerosis studies, including traditional two-dimensional (2D) systems cultured on the tissue culture plate, 2D cell sheets, and recently emerged microfluidic chip models with 2D culture. In addition, advanced in vitro three-dimensional models such as spheroids, cell-laden hydrogel constructs, tissue-engineered blood vessels, and vessel-on-a-chip will also be covered. Moreover, the functions of these models are also summarized along with model discussion. Lastly, the future perspectives of this field are discussed.https://www.frontiersin.org/articles/10.3389/fcvm.2021.790529/fullatherosclerosisdisease modelstissue-engineered blood vesselsmicrofluidic chipsin vitro models and methods |
| spellingShingle | Jun Chen Xixi Zhang Reid Millican Tyler Lynd Manas Gangasani Shubh Malhotra Jennifer Sherwood Patrick Taejoon Hwang Younghye Cho Younghye Cho Brigitta C. Brott Brigitta C. Brott Brigitta C. Brott Gangjian Qin Hanjoong Jo Young-sup Yoon Young-sup Yoon Ho-Wook Jun Ho-Wook Jun Recent Progress in in vitro Models for Atherosclerosis Studies Frontiers in Cardiovascular Medicine atherosclerosis disease models tissue-engineered blood vessels microfluidic chips in vitro models and methods |
| title | Recent Progress in in vitro Models for Atherosclerosis Studies |
| title_full | Recent Progress in in vitro Models for Atherosclerosis Studies |
| title_fullStr | Recent Progress in in vitro Models for Atherosclerosis Studies |
| title_full_unstemmed | Recent Progress in in vitro Models for Atherosclerosis Studies |
| title_short | Recent Progress in in vitro Models for Atherosclerosis Studies |
| title_sort | recent progress in in vitro models for atherosclerosis studies |
| topic | atherosclerosis disease models tissue-engineered blood vessels microfluidic chips in vitro models and methods |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2021.790529/full |
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