The Search for Genetic Risk Factors of Type 2 Diabetes Mellitus
Type 2 diabetes mellitus (T2DM) is caused by complex interplay between multiple genetic and environmental factors. The three major approaches used to identify the genetic susceptibility include candidate gene approach, familial linkage analysis and genome- wide association analysis. Recent advance i...
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| Format: | Article |
| Language: | English |
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Korean Diabetes Association
2011-02-01
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| Series: | Diabetes & Metabolism Journal |
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| Online Access: | http://e-dmj.org/Synapse/Data/PDFData/2004DMJ/dmj-35-12.pdf |
| _version_ | 1811324498930040832 |
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| author | Kyong Soo Park |
| author_facet | Kyong Soo Park |
| author_sort | Kyong Soo Park |
| collection | DOAJ |
| description | Type 2 diabetes mellitus (T2DM) is caused by complex interplay between multiple genetic and environmental factors. The three major approaches used to identify the genetic susceptibility include candidate gene approach, familial linkage analysis and genome- wide association analysis. Recent advance in genome-wide association studies have greatly improved our understanding of the pathophysiology of T2DM. As of the end of 2010, there are more than 40 confirmed T2DM-associated genetic loci. Most of the T2DM susceptibility genes were implicated in decreased β-cell function. However, these genetic variations have a modest effect and their combination only explains less than 10% of the T2DM heritability. With the advent of the next-generation sequencing technology, we will soon identify rare variants of larger effect as well as causal variants. These advances in understanding the genetics of T2DM will lead to the development of new therapeutic and preventive strategies and individualized medicine. |
| first_indexed | 2024-04-13T14:15:25Z |
| format | Article |
| id | doaj.art-81f115c1712c41708d7cd664c13d84b6 |
| institution | Directory Open Access Journal |
| issn | 2233-6079 2233-6087 |
| language | English |
| last_indexed | 2024-04-13T14:15:25Z |
| publishDate | 2011-02-01 |
| publisher | Korean Diabetes Association |
| record_format | Article |
| series | Diabetes & Metabolism Journal |
| spelling | doaj.art-81f115c1712c41708d7cd664c13d84b62022-12-22T02:43:39ZengKorean Diabetes AssociationDiabetes & Metabolism Journal2233-60792233-60872011-02-01351122210.4093/dmj.2011.35.1.122742The Search for Genetic Risk Factors of Type 2 Diabetes MellitusKyong Soo ParkType 2 diabetes mellitus (T2DM) is caused by complex interplay between multiple genetic and environmental factors. The three major approaches used to identify the genetic susceptibility include candidate gene approach, familial linkage analysis and genome- wide association analysis. Recent advance in genome-wide association studies have greatly improved our understanding of the pathophysiology of T2DM. As of the end of 2010, there are more than 40 confirmed T2DM-associated genetic loci. Most of the T2DM susceptibility genes were implicated in decreased β-cell function. However, these genetic variations have a modest effect and their combination only explains less than 10% of the T2DM heritability. With the advent of the next-generation sequencing technology, we will soon identify rare variants of larger effect as well as causal variants. These advances in understanding the genetics of T2DM will lead to the development of new therapeutic and preventive strategies and individualized medicine.http://e-dmj.org/Synapse/Data/PDFData/2004DMJ/dmj-35-12.pdfDiabetes mellitus, type 2GeneGenome-wide association studiesHeritabilityNext generation sequencingSingle nucleotide polymorphism |
| spellingShingle | Kyong Soo Park The Search for Genetic Risk Factors of Type 2 Diabetes Mellitus Diabetes & Metabolism Journal Diabetes mellitus, type 2 Gene Genome-wide association studies Heritability Next generation sequencing Single nucleotide polymorphism |
| title | The Search for Genetic Risk Factors of Type 2 Diabetes Mellitus |
| title_full | The Search for Genetic Risk Factors of Type 2 Diabetes Mellitus |
| title_fullStr | The Search for Genetic Risk Factors of Type 2 Diabetes Mellitus |
| title_full_unstemmed | The Search for Genetic Risk Factors of Type 2 Diabetes Mellitus |
| title_short | The Search for Genetic Risk Factors of Type 2 Diabetes Mellitus |
| title_sort | search for genetic risk factors of type 2 diabetes mellitus |
| topic | Diabetes mellitus, type 2 Gene Genome-wide association studies Heritability Next generation sequencing Single nucleotide polymorphism |
| url | http://e-dmj.org/Synapse/Data/PDFData/2004DMJ/dmj-35-12.pdf |
| work_keys_str_mv | AT kyongsoopark thesearchforgeneticriskfactorsoftype2diabetesmellitus AT kyongsoopark searchforgeneticriskfactorsoftype2diabetesmellitus |