Seventy Years of Treating Delusional Disorder with Antipsychotics: A Historical Perspective
For many decades, delusional disorder (DD) has been considered a treatment-resistant disorder, with antipsychotics acknowledged as the best, though imperfect, treatment. It is possible that the discovery of the right drug could turn treatment resistance into treatment response. The goal of this narr...
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| Format: | Article |
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MDPI AG
2022-12-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/10/12/3281 |
| _version_ | 1827641617767464960 |
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| author | Alexandre González-Rodríguez José A. Monreal Mentxu Natividad Mary V. Seeman |
| author_facet | Alexandre González-Rodríguez José A. Monreal Mentxu Natividad Mary V. Seeman |
| author_sort | Alexandre González-Rodríguez |
| collection | DOAJ |
| description | For many decades, delusional disorder (DD) has been considered a treatment-resistant disorder, with antipsychotics acknowledged as the best, though imperfect, treatment. It is possible that the discovery of the right drug could turn treatment resistance into treatment response. The goal of this narrative review is to provide a historical perspective of the treatment of DD since the introduction of antipsychotics 70 years ago. The following search terms were used to scan the literature: antipsychotics AND “delusional disorder”. Findings were that therapy for DD symptoms has changed over time. Initial reports suggested that the drug of choice was the antipsychotic pimozide, and that this drug was especially effective for the somatic subtype of DD. Subsequent studies demonstrated that other antipsychotics, for instance, risperidone and olanzapine, were also highly effective. Treatment response may vary according to the presence or absence of specific symptoms, such as cognitive defect and depression. Clozapine, partial D2 agonists, and long-acting injectable drugs may be more effective than other drugs, but the evidence is not yet in. Because of the absence of robust evidence, treatment guidelines for the optimal management of DD are not yet available. |
| first_indexed | 2024-03-09T17:17:21Z |
| format | Article |
| id | doaj.art-81f22a87fda947708fb57f080b898855 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-09T17:17:21Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-81f22a87fda947708fb57f080b8988552023-11-24T13:29:58ZengMDPI AGBiomedicines2227-90592022-12-011012328110.3390/biomedicines10123281Seventy Years of Treating Delusional Disorder with Antipsychotics: A Historical PerspectiveAlexandre González-Rodríguez0José A. Monreal1Mentxu Natividad2Mary V. Seeman3Department of Mental Health, Mutua Terrassa University Hospital, Fundació Docència I Recerca Mutua Terrassa, University of Barcelona (UB), CIBERSAM, 5 Dr Robert Square, 08221 Terrassa, SpainDepartment of Mental Health, Mutua Terrassa University Hospital, Fundació Docència I Recerca Mutua Terrassa, University of Barcelona (UB), CIBERSAM, 5 Dr Robert Square, 08221 Terrassa, SpainDepartment of Mental Health, Mutua Terrassa University Hospital, Fundació Docència I Recerca Mutua Terrassa, University of Barcelona (UB), CIBERSAM, 5 Dr Robert Square, 08221 Terrassa, SpainDepartment of Psychiatry, University of Toronto, 605 260 Health Street West, Toronto, ON M5P 3L6, CanadaFor many decades, delusional disorder (DD) has been considered a treatment-resistant disorder, with antipsychotics acknowledged as the best, though imperfect, treatment. It is possible that the discovery of the right drug could turn treatment resistance into treatment response. The goal of this narrative review is to provide a historical perspective of the treatment of DD since the introduction of antipsychotics 70 years ago. The following search terms were used to scan the literature: antipsychotics AND “delusional disorder”. Findings were that therapy for DD symptoms has changed over time. Initial reports suggested that the drug of choice was the antipsychotic pimozide, and that this drug was especially effective for the somatic subtype of DD. Subsequent studies demonstrated that other antipsychotics, for instance, risperidone and olanzapine, were also highly effective. Treatment response may vary according to the presence or absence of specific symptoms, such as cognitive defect and depression. Clozapine, partial D2 agonists, and long-acting injectable drugs may be more effective than other drugs, but the evidence is not yet in. Because of the absence of robust evidence, treatment guidelines for the optimal management of DD are not yet available.https://www.mdpi.com/2227-9059/10/12/3281optimizing treatmentschizophrenia spectrumpimozidepartial D2 agonists |
| spellingShingle | Alexandre González-Rodríguez José A. Monreal Mentxu Natividad Mary V. Seeman Seventy Years of Treating Delusional Disorder with Antipsychotics: A Historical Perspective Biomedicines optimizing treatment schizophrenia spectrum pimozide partial D2 agonists |
| title | Seventy Years of Treating Delusional Disorder with Antipsychotics: A Historical Perspective |
| title_full | Seventy Years of Treating Delusional Disorder with Antipsychotics: A Historical Perspective |
| title_fullStr | Seventy Years of Treating Delusional Disorder with Antipsychotics: A Historical Perspective |
| title_full_unstemmed | Seventy Years of Treating Delusional Disorder with Antipsychotics: A Historical Perspective |
| title_short | Seventy Years of Treating Delusional Disorder with Antipsychotics: A Historical Perspective |
| title_sort | seventy years of treating delusional disorder with antipsychotics a historical perspective |
| topic | optimizing treatment schizophrenia spectrum pimozide partial D2 agonists |
| url | https://www.mdpi.com/2227-9059/10/12/3281 |
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