Healing Effects of Dried and Acellular Human Amniotic Membrane and Mepitelas for Coverage of Skin Graft Donor Areas; A Randomized Clinical Trial
Objective: To compare the healing effects of dried and acellular human amniotic membrane and Mepitel for coverage of split-thickness graft donor site (STGDS). Methods: Twenty patients who underwent STGDS regeneration surgery in identical anatomic regions were enrolled in this randomized controlled...
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| Format: | Article |
| Language: | English |
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Shiraz University of Medical Sciences
2018-07-01
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| Series: | Bulletin of Emergency and Trauma |
| Subjects: | |
| Online Access: | http://beat.sums.ac.ir/article_44434_64b973d4574584995b096577ba8ca2b5.pdf |
| _version_ | 1818939169301331968 |
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| author | Masoumeh Nouri Marzieh Ebrahimi Tooran Bagheri Mohammad Javad Fatemi Arash Najafbeygi Shirin Araghi Maryam Molaee |
| author_facet | Masoumeh Nouri Marzieh Ebrahimi Tooran Bagheri Mohammad Javad Fatemi Arash Najafbeygi Shirin Araghi Maryam Molaee |
| author_sort | Masoumeh Nouri |
| collection | DOAJ |
| description | Objective: To compare the healing effects of dried and acellular human amniotic membrane and Mepitel for coverage of split-thickness graft donor site (STGDS). Methods: Twenty patients who underwent STGDS regeneration surgery in identical anatomic regions were enrolled in this randomized controlled clinical trial conducted in Hazrate Fatemeh hospital (Iran). Patients were randomly assigned in 3 groups of wound dressing; group A by Mepitel, group B AmiCare (Dried amniotic membrane) and group C OcuReg-A (Acellular amniotic membrane). Re-epithelization rate (healing time), pain sensation, scar formation and infection rate were assessed till complete healing was achieved.Results: Our results showed no significant difference between Amicare, OcuReg-A and Mepitel in the features analyzed by us including: Re-epithelization rate (healing time) P value; 0.573, Pain sensation P value: day 4 th: 0.131, day8 th: 0.93 and day 12 th: 0.365, Scar formation P value>0.05 and Infection rate.Conclusion: Our findings confirmed the safety and efficacy of AmiCare (dried amniotic membrane) and OcuReg-A (Acellular amniotic membrane) in treatment of split-thickness donor site in comparison with Mepitel as a standard wound dressing.Trial registration number: IRCT201511118177N12. |
| first_indexed | 2024-12-20T06:19:28Z |
| format | Article |
| id | doaj.art-81f2b0d81ba34b7a83cb34044a4106a9 |
| institution | Directory Open Access Journal |
| issn | 2322-2522 2322-3960 |
| language | English |
| last_indexed | 2024-12-20T06:19:28Z |
| publishDate | 2018-07-01 |
| publisher | Shiraz University of Medical Sciences |
| record_format | Article |
| series | Bulletin of Emergency and Trauma |
| spelling | doaj.art-81f2b0d81ba34b7a83cb34044a4106a92022-12-21T19:50:27ZengShiraz University of Medical SciencesBulletin of Emergency and Trauma2322-25222322-39602018-07-016Issue 319520044434Healing Effects of Dried and Acellular Human Amniotic Membrane and Mepitelas for Coverage of Skin Graft Donor Areas; A Randomized Clinical TrialMasoumeh Nouri0Marzieh Ebrahimi1Tooran Bagheri2Mohammad Javad Fatemi3Arash Najafbeygi4Shirin Araghi5Maryam Molaee61 Ph.D. of Molecular genetics, Department of Regenerative Biomedicine, Cell Science Research Center, Royan Institute, Tehran, IranAssociated Professor, Department of Regenerative Biomedicine, Cell Science Research Center, Royan Institute, Tehran, IranBurn research Center, Iran University of Medical Sciences, Tehran, IranProfessor, Burn research Center, Iran University of Medical Sciences, Tehran, IranResident of plastic surgery, Hazrat Fatima Hospital, Iran University of Medical Sciences, Tehran, IranBSc of Nursing, Hazrat Fatima Hospital, Iran University of Medical Sciences, Tehran, IranBSc of Midwife, Department of Regenerative Biomedicine, Cell Science Research Center, Royan Institute, Tehran, IranObjective: To compare the healing effects of dried and acellular human amniotic membrane and Mepitel for coverage of split-thickness graft donor site (STGDS). Methods: Twenty patients who underwent STGDS regeneration surgery in identical anatomic regions were enrolled in this randomized controlled clinical trial conducted in Hazrate Fatemeh hospital (Iran). Patients were randomly assigned in 3 groups of wound dressing; group A by Mepitel, group B AmiCare (Dried amniotic membrane) and group C OcuReg-A (Acellular amniotic membrane). Re-epithelization rate (healing time), pain sensation, scar formation and infection rate were assessed till complete healing was achieved.Results: Our results showed no significant difference between Amicare, OcuReg-A and Mepitel in the features analyzed by us including: Re-epithelization rate (healing time) P value; 0.573, Pain sensation P value: day 4 th: 0.131, day8 th: 0.93 and day 12 th: 0.365, Scar formation P value>0.05 and Infection rate.Conclusion: Our findings confirmed the safety and efficacy of AmiCare (dried amniotic membrane) and OcuReg-A (Acellular amniotic membrane) in treatment of split-thickness donor site in comparison with Mepitel as a standard wound dressing.Trial registration number: IRCT201511118177N12.http://beat.sums.ac.ir/article_44434_64b973d4574584995b096577ba8ca2b5.pdfSplit-thickness donor siteDried amniotic membraneAcellular amniotic membraneMepitelRe-epithelization |
| spellingShingle | Masoumeh Nouri Marzieh Ebrahimi Tooran Bagheri Mohammad Javad Fatemi Arash Najafbeygi Shirin Araghi Maryam Molaee Healing Effects of Dried and Acellular Human Amniotic Membrane and Mepitelas for Coverage of Skin Graft Donor Areas; A Randomized Clinical Trial Bulletin of Emergency and Trauma Split-thickness donor site Dried amniotic membrane Acellular amniotic membrane Mepitel Re-epithelization |
| title | Healing Effects of Dried and Acellular Human Amniotic Membrane and Mepitelas for Coverage of Skin Graft Donor Areas; A Randomized Clinical Trial |
| title_full | Healing Effects of Dried and Acellular Human Amniotic Membrane and Mepitelas for Coverage of Skin Graft Donor Areas; A Randomized Clinical Trial |
| title_fullStr | Healing Effects of Dried and Acellular Human Amniotic Membrane and Mepitelas for Coverage of Skin Graft Donor Areas; A Randomized Clinical Trial |
| title_full_unstemmed | Healing Effects of Dried and Acellular Human Amniotic Membrane and Mepitelas for Coverage of Skin Graft Donor Areas; A Randomized Clinical Trial |
| title_short | Healing Effects of Dried and Acellular Human Amniotic Membrane and Mepitelas for Coverage of Skin Graft Donor Areas; A Randomized Clinical Trial |
| title_sort | healing effects of dried and acellular human amniotic membrane and mepitelas for coverage of skin graft donor areas a randomized clinical trial |
| topic | Split-thickness donor site Dried amniotic membrane Acellular amniotic membrane Mepitel Re-epithelization |
| url | http://beat.sums.ac.ir/article_44434_64b973d4574584995b096577ba8ca2b5.pdf |
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