Markers for human haematopoietic stem cells: The disconnect between an identification marker and its function
The haematopoietic system is a classical stem cell hierarchy that maintains all the blood cells in the body. Haematopoietic stem cells (HSCs) are rare, highly potent cells that reside at the apex of this hierarchy and are historically some of the most well studied stem cells in humans and laboratory...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Physiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2022.1009160/full |
| _version_ | 1818031066410123264 |
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| author | Beatrice Rix Andres Hernandez Maduro Katherine S. Bridge William Grey |
| author_facet | Beatrice Rix Andres Hernandez Maduro Katherine S. Bridge William Grey |
| author_sort | Beatrice Rix |
| collection | DOAJ |
| description | The haematopoietic system is a classical stem cell hierarchy that maintains all the blood cells in the body. Haematopoietic stem cells (HSCs) are rare, highly potent cells that reside at the apex of this hierarchy and are historically some of the most well studied stem cells in humans and laboratory models, with haematopoiesis being the original system to define functional cell types by cell surface markers. Whilst it is possible to isolate HSCs to near purity, we know very little about the functional activity of markers to purify HSCs. This review will focus on the historical efforts to purify HSCs in humans based on cell surface markers, their putative functions and recent advances in finding functional markers on HSCs. |
| first_indexed | 2024-12-10T05:45:34Z |
| format | Article |
| id | doaj.art-81f41930c2d348d8afec038a07043cb3 |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-12-10T05:45:34Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-81f41930c2d348d8afec038a07043cb32022-12-22T02:00:10ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2022-09-011310.3389/fphys.2022.10091601009160Markers for human haematopoietic stem cells: The disconnect between an identification marker and its functionBeatrice RixAndres Hernandez MaduroKatherine S. BridgeWilliam GreyThe haematopoietic system is a classical stem cell hierarchy that maintains all the blood cells in the body. Haematopoietic stem cells (HSCs) are rare, highly potent cells that reside at the apex of this hierarchy and are historically some of the most well studied stem cells in humans and laboratory models, with haematopoiesis being the original system to define functional cell types by cell surface markers. Whilst it is possible to isolate HSCs to near purity, we know very little about the functional activity of markers to purify HSCs. This review will focus on the historical efforts to purify HSCs in humans based on cell surface markers, their putative functions and recent advances in finding functional markers on HSCs.https://www.frontiersin.org/articles/10.3389/fphys.2022.1009160/fullhaematopoietic stem cellhaematopoiesisstem cell isolationstem cell purificationstem cell functional markers |
| spellingShingle | Beatrice Rix Andres Hernandez Maduro Katherine S. Bridge William Grey Markers for human haematopoietic stem cells: The disconnect between an identification marker and its function Frontiers in Physiology haematopoietic stem cell haematopoiesis stem cell isolation stem cell purification stem cell functional markers |
| title | Markers for human haematopoietic stem cells: The disconnect between an identification marker and its function |
| title_full | Markers for human haematopoietic stem cells: The disconnect between an identification marker and its function |
| title_fullStr | Markers for human haematopoietic stem cells: The disconnect between an identification marker and its function |
| title_full_unstemmed | Markers for human haematopoietic stem cells: The disconnect between an identification marker and its function |
| title_short | Markers for human haematopoietic stem cells: The disconnect between an identification marker and its function |
| title_sort | markers for human haematopoietic stem cells the disconnect between an identification marker and its function |
| topic | haematopoietic stem cell haematopoiesis stem cell isolation stem cell purification stem cell functional markers |
| url | https://www.frontiersin.org/articles/10.3389/fphys.2022.1009160/full |
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