Compatibility and efficiency of preservatives in emulsive cosmetics containing high surfactant content
Abstract The objective of this study was to determine the influence of nonionic surfactants on the effectiveness of preservatives used in emulsions containing high surfactant content. Mixtures of different concentrations were prepared between polyethoxylated (40) hydrogenated castor oil (PHCO) and p...
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| Format: | Article |
| Language: | English |
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Universidade de São Paulo
2022-08-01
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| Series: | Brazilian Journal of Pharmaceutical Sciences |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502022000100684&lng=en&tlng=en |
| _version_ | 1811339622499745792 |
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| author | Priscila de Oliveira Schmitt Ana Flávia Fischer Ruth Meri Lucinda da Silva Alexandre Bella Cruz |
| author_facet | Priscila de Oliveira Schmitt Ana Flávia Fischer Ruth Meri Lucinda da Silva Alexandre Bella Cruz |
| author_sort | Priscila de Oliveira Schmitt |
| collection | DOAJ |
| description | Abstract The objective of this study was to determine the influence of nonionic surfactants on the effectiveness of preservatives used in emulsions containing high surfactant content. Mixtures of different concentrations were prepared between polyethoxylated (40) hydrogenated castor oil (PHCO) and polyoxyethylene sorbitan monooleate (PSO), with methylparaben, phenoxyethanol, methylparaben, ethylparaben, propylparaben, and isobutylparaben (PMEPBI) blend, phenoxyethanol and benzoic acid (BP) blend, and phenoxyethanol and caprylyl glycol (PC) blend. Subsequently, the compatibility of the formulation ingredients and the effectiveness of the preservatives were evaluated by the challenge test. It was found that PHCO and PSO inactivated the antimicrobial action of methylparaben and PMEPBI. Paraben-free preservatives BP and PC had less influence on surfactants than systems containing parabens. When incorporated into microemulsions and nanoemulsions containing 40% and 20% surfactants, methylparaben and BP 0.2% and 0.5% were only effective against Aspergillus niger. The PMEPBI 0.2% was effective as a preservative in nanoemulsified formulations against A. niger, Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus. The results demonstrate that the efficacy of the preservative system in formulations containing nonionic surfactant excipients depends on the type of excipient, the components of the formulation, the preservative systems composition, the excipient to preservative ratio, and the availability in the formulation. |
| first_indexed | 2024-04-13T18:29:37Z |
| format | Article |
| id | doaj.art-81f5448fa3784d60ae12fd3e8974961a |
| institution | Directory Open Access Journal |
| issn | 2175-9790 |
| language | English |
| last_indexed | 2024-04-13T18:29:37Z |
| publishDate | 2022-08-01 |
| publisher | Universidade de São Paulo |
| record_format | Article |
| series | Brazilian Journal of Pharmaceutical Sciences |
| spelling | doaj.art-81f5448fa3784d60ae12fd3e8974961a2022-12-22T02:35:09ZengUniversidade de São PauloBrazilian Journal of Pharmaceutical Sciences2175-97902022-08-015810.1590/s2175-97902022e191088Compatibility and efficiency of preservatives in emulsive cosmetics containing high surfactant contentPriscila de Oliveira SchmittAna Flávia FischerRuth Meri Lucinda da SilvaAlexandre Bella Cruzhttps://orcid.org/0000-0002-3944-9265Abstract The objective of this study was to determine the influence of nonionic surfactants on the effectiveness of preservatives used in emulsions containing high surfactant content. Mixtures of different concentrations were prepared between polyethoxylated (40) hydrogenated castor oil (PHCO) and polyoxyethylene sorbitan monooleate (PSO), with methylparaben, phenoxyethanol, methylparaben, ethylparaben, propylparaben, and isobutylparaben (PMEPBI) blend, phenoxyethanol and benzoic acid (BP) blend, and phenoxyethanol and caprylyl glycol (PC) blend. Subsequently, the compatibility of the formulation ingredients and the effectiveness of the preservatives were evaluated by the challenge test. It was found that PHCO and PSO inactivated the antimicrobial action of methylparaben and PMEPBI. Paraben-free preservatives BP and PC had less influence on surfactants than systems containing parabens. When incorporated into microemulsions and nanoemulsions containing 40% and 20% surfactants, methylparaben and BP 0.2% and 0.5% were only effective against Aspergillus niger. The PMEPBI 0.2% was effective as a preservative in nanoemulsified formulations against A. niger, Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus. The results demonstrate that the efficacy of the preservative system in formulations containing nonionic surfactant excipients depends on the type of excipient, the components of the formulation, the preservative systems composition, the excipient to preservative ratio, and the availability in the formulation.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502022000100684&lng=en&tlng=enMicroemulsionNanocompositionFormulationExcipientStability |
| spellingShingle | Priscila de Oliveira Schmitt Ana Flávia Fischer Ruth Meri Lucinda da Silva Alexandre Bella Cruz Compatibility and efficiency of preservatives in emulsive cosmetics containing high surfactant content Brazilian Journal of Pharmaceutical Sciences Microemulsion Nanocomposition Formulation Excipient Stability |
| title | Compatibility and efficiency of preservatives in emulsive cosmetics containing high surfactant content |
| title_full | Compatibility and efficiency of preservatives in emulsive cosmetics containing high surfactant content |
| title_fullStr | Compatibility and efficiency of preservatives in emulsive cosmetics containing high surfactant content |
| title_full_unstemmed | Compatibility and efficiency of preservatives in emulsive cosmetics containing high surfactant content |
| title_short | Compatibility and efficiency of preservatives in emulsive cosmetics containing high surfactant content |
| title_sort | compatibility and efficiency of preservatives in emulsive cosmetics containing high surfactant content |
| topic | Microemulsion Nanocomposition Formulation Excipient Stability |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502022000100684&lng=en&tlng=en |
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