Cooperation between HMGA1, PDX-1 and MafA is essential for glucose-induced insulin transcription in pancreatic beta cells

Cooperation between HMGA1, PDX-1 and MafA is essential for glucose-induced insulin transcription in pancreatic beta cells

The high-mobility group AT-hook 1 (HMGA1) protein is a nuclear architectural factor that can organize chromatin structures. It regulates gene expression by controlling the formation of stereospecific multiprotein complexes called enhanceosomes on the AT-rich regions of target gene promoters. Previou...

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Bibliographic Details
Main Authors: Biagio eArcidiacono, Stefania eIiritano, Eusebio eChiefari, Francesco S. eBrunetti, Guoqiang eGu, Daniela Patrizia Foti, Antonio eBrunetti
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-01-01
Series:Frontiers in Endocrinology
Subjects:
Diabetes Mellitus
Transcription Factors
Insulin gene
β-cells
HMGA1
MafA
Online Access:http://journal.frontiersin.org/Journal/10.3389/fendo.2014.00237/full

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