Cannabidiol Protects Dopaminergic Neurons in Mesencephalic Cultures against the Complex I Inhibitor Rotenone Via Modulation of Heme Oxygenase Activity and Bilirubin

Cannabidiol Protects Dopaminergic Neurons in Mesencephalic Cultures against the Complex I Inhibitor Rotenone Via Modulation of Heme Oxygenase Activity and Bilirubin

Phytocannabinoids protect neurons against stressful conditions, possibly via the heme oxygenase (HO) system. In cultures of primary mesencephalic neurons and neuroblastoma cells, we determined the capability of cannabidiol (CBD) and tetrahydrocannabinol (THC) to counteract effects elicited by comple...

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Bibliographic Details
Main Authors: Johanna Catharina Duvigneau, Alice Trovato, Andrea Müllebner, Ingrid Miller, Christopher Krewenka, Kristina Krenn, Wilhelm Zich, Rudolf Moldzio
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:Antioxidants
Subjects:
phytocannabinoids
heme oxygenase
biliverdin reductase
bilirubin
rotenone
neuroprotection
Online Access:https://www.mdpi.com/2076-3921/9/2/135

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