Molecular Mechanisms in Early Diabetic Kidney Disease: Glomerular Endothelial Cell Dysfunction
Diabetic kidney disease (DKD) is the leading cause of end-stage renal disease (ESRD), with prevalence increasing at an alarming rate worldwide and today, there are no known cures. The pathogenesis of DKD is complex, influenced by genetics and the environment. However, the underlying molecular mechan...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-12-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/21/24/9456 |
| _version_ | 1797544960924319744 |
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| author | Emelie Lassén Ilse S. Daehn |
| author_facet | Emelie Lassén Ilse S. Daehn |
| author_sort | Emelie Lassén |
| collection | DOAJ |
| description | Diabetic kidney disease (DKD) is the leading cause of end-stage renal disease (ESRD), with prevalence increasing at an alarming rate worldwide and today, there are no known cures. The pathogenesis of DKD is complex, influenced by genetics and the environment. However, the underlying molecular mechanisms that contribute to DKD risk in about one-third of diabetics are still poorly understood. The early stage of DKD is characterized by glomerular hyperfiltration, hypertrophy, podocyte injury and depletion. Recent evidence of glomerular endothelial cell injury at the early stage of DKD has been suggested to be critical in the pathological process and has highlighted the importance of glomerular intercellular crosstalk. A potential mechanism may include reactive oxygen species (ROS), which play a direct role in diabetes and its complications. In this review, we discuss different cellular sources of ROS in diabetes and a new emerging paradigm of endothelial cell dysfunction as a key event in the pathogenesis of DKD. |
| first_indexed | 2024-03-10T14:07:52Z |
| format | Article |
| id | doaj.art-81f81b97cd4c4252b35a0857f0043704 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T14:07:52Z |
| publishDate | 2020-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-81f81b97cd4c4252b35a0857f00437042023-11-21T00:28:21ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-12-012124945610.3390/ijms21249456Molecular Mechanisms in Early Diabetic Kidney Disease: Glomerular Endothelial Cell DysfunctionEmelie Lassén0Ilse S. Daehn1Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USADivision of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USADiabetic kidney disease (DKD) is the leading cause of end-stage renal disease (ESRD), with prevalence increasing at an alarming rate worldwide and today, there are no known cures. The pathogenesis of DKD is complex, influenced by genetics and the environment. However, the underlying molecular mechanisms that contribute to DKD risk in about one-third of diabetics are still poorly understood. The early stage of DKD is characterized by glomerular hyperfiltration, hypertrophy, podocyte injury and depletion. Recent evidence of glomerular endothelial cell injury at the early stage of DKD has been suggested to be critical in the pathological process and has highlighted the importance of glomerular intercellular crosstalk. A potential mechanism may include reactive oxygen species (ROS), which play a direct role in diabetes and its complications. In this review, we discuss different cellular sources of ROS in diabetes and a new emerging paradigm of endothelial cell dysfunction as a key event in the pathogenesis of DKD.https://www.mdpi.com/1422-0067/21/24/9456diabetic kidney diseaseglomerular endothelial cellsROS |
| spellingShingle | Emelie Lassén Ilse S. Daehn Molecular Mechanisms in Early Diabetic Kidney Disease: Glomerular Endothelial Cell Dysfunction International Journal of Molecular Sciences diabetic kidney disease glomerular endothelial cells ROS |
| title | Molecular Mechanisms in Early Diabetic Kidney Disease: Glomerular Endothelial Cell Dysfunction |
| title_full | Molecular Mechanisms in Early Diabetic Kidney Disease: Glomerular Endothelial Cell Dysfunction |
| title_fullStr | Molecular Mechanisms in Early Diabetic Kidney Disease: Glomerular Endothelial Cell Dysfunction |
| title_full_unstemmed | Molecular Mechanisms in Early Diabetic Kidney Disease: Glomerular Endothelial Cell Dysfunction |
| title_short | Molecular Mechanisms in Early Diabetic Kidney Disease: Glomerular Endothelial Cell Dysfunction |
| title_sort | molecular mechanisms in early diabetic kidney disease glomerular endothelial cell dysfunction |
| topic | diabetic kidney disease glomerular endothelial cells ROS |
| url | https://www.mdpi.com/1422-0067/21/24/9456 |
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