Dabigatran and Argatroban Diametrically Modulate Thrombin Exosite Function.

Dabigatran and Argatroban Diametrically Modulate Thrombin Exosite Function.

Thrombin is a highly plastic molecule whose activity and specificity are regulated by exosites 1 and 2, positively-charged domains that flank the active site. Exosite binding by substrates and cofactors regulates thrombin activity by localizing thrombin, guiding substrates, and by inducing allosteri...

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Bibliographic Details
Main Authors: Calvin H Yeh, Alan R Stafford, Beverly A Leslie, James C Fredenburgh, Jeffrey I Weitz
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4909201?pdf=render

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