CD137 expression is induced by Epstein-Barr virus infection through LMP1 in T or NK cells and mediates survival promoting signals.

CD137 expression is induced by Epstein-Barr virus infection through LMP1 in T or NK cells and mediates survival promoting signals.

To clarify the mechanism for development of Epstein-Barr virus (EBV)-positive T- or NK-cell neoplasms, we focused on the costimulatory receptor CD137. We detected high expression of CD137 gene and its protein on EBV-positive T- or NK-cell lines as compared with EBV-negative cell lines. EBV-positive...

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Bibliographic Details
Main Authors: Mayumi Yoshimori, Ken-Ichi Imadome, Honami Komatsu, Ludan Wang, Yasunori Saitoh, Shoji Yamaoka, Tetsuya Fukuda, Morito Kurata, Takatoshi Koyama, Norio Shimizu, Shigeyoshi Fujiwara, Osamu Miura, Ayako Arai
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4237363?pdf=render

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