Lipid–polymer hybrid nanoparticles as a next-generation drug delivery platform: state of the art, emerging technologies, and perspectives
Anubhab Mukherjee,1,2 Ariana K Waters,1,2 Pranav Kalyan,3 Achal Singh Achrol,2 Santosh Kesari,2 Venkata Mahidhar Yenugonda1,2 1Drug Discovery and Nanomedicine Research Program, 2Department of Translational Neurosciences and Neurotherapeutics, John Wayne Cancer Institute, Pacific Neuroscience Instit...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2019-03-01
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| Series: | International Journal of Nanomedicine |
| Subjects: | |
| Online Access: | https://www.dovepress.com/lipid-polymer-hybrid-nanoparticles-as-a-next-generation-drug-delivery--peer-reviewed-article-IJN |
| _version_ | 1818571571104579584 |
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| author | Mukherjee A Waters AK Kalyan P Achrol AS Kesari S Yenugonda VM |
| author_facet | Mukherjee A Waters AK Kalyan P Achrol AS Kesari S Yenugonda VM |
| author_sort | Mukherjee A |
| collection | DOAJ |
| description | Anubhab Mukherjee,1,2 Ariana K Waters,1,2 Pranav Kalyan,3 Achal Singh Achrol,2 Santosh Kesari,2 Venkata Mahidhar Yenugonda1,2 1Drug Discovery and Nanomedicine Research Program, 2Department of Translational Neurosciences and Neurotherapeutics, John Wayne Cancer Institute, Pacific Neuroscience Institute, Providence Saint John’s Health Center, Santa Monica, CA, USA; 3Agoura High School, Agoura Hills, CA, USA Abstract: Lipid–polymer hybrid nanoparticles (LPHNPs) are next-generation core–shell nanostructures, conceptually derived from both liposome and polymeric nanoparticles (NPs), where a polymer core remains enveloped by a lipid layer. Although they have garnered significant interest, they remain not yet widely exploited or ubiquitous. Recently, a fundamental transformation has occurred in the preparation of LPHNPs, characterized by a transition from a two-step to a one-step strategy, involving synchronous self-assembly of polymers and lipids. Owing to its two-in-one structure, this approach is of particular interest as a combinatorial drug delivery platform in oncology. In particular, the outer surface can be decorated in multifarious ways for active targeting of anticancer therapy, delivery of DNA or RNA materials, and use as a diagnostic imaging agent. This review will provide an update on recent key advancements in design, synthesis, and bioactivity evaluation as well as discussion of future clinical possibilities of LPHNPs. Keywords: lipid–polymer hybrid nanoparticle, lipid-based nanoparticle, polymer-based nanoparticles, drug delivery, gene delivery |
| first_indexed | 2024-12-14T13:57:45Z |
| format | Article |
| id | doaj.art-81f972ce6c44469f9b9de137c86ec48b |
| institution | Directory Open Access Journal |
| issn | 1178-2013 |
| language | English |
| last_indexed | 2024-12-14T13:57:45Z |
| publishDate | 2019-03-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | International Journal of Nanomedicine |
| spelling | doaj.art-81f972ce6c44469f9b9de137c86ec48b2022-12-21T22:58:49ZengDove Medical PressInternational Journal of Nanomedicine1178-20132019-03-01Volume 141937195244636Lipid–polymer hybrid nanoparticles as a next-generation drug delivery platform: state of the art, emerging technologies, and perspectivesMukherjee AWaters AKKalyan PAchrol ASKesari SYenugonda VMAnubhab Mukherjee,1,2 Ariana K Waters,1,2 Pranav Kalyan,3 Achal Singh Achrol,2 Santosh Kesari,2 Venkata Mahidhar Yenugonda1,2 1Drug Discovery and Nanomedicine Research Program, 2Department of Translational Neurosciences and Neurotherapeutics, John Wayne Cancer Institute, Pacific Neuroscience Institute, Providence Saint John’s Health Center, Santa Monica, CA, USA; 3Agoura High School, Agoura Hills, CA, USA Abstract: Lipid–polymer hybrid nanoparticles (LPHNPs) are next-generation core–shell nanostructures, conceptually derived from both liposome and polymeric nanoparticles (NPs), where a polymer core remains enveloped by a lipid layer. Although they have garnered significant interest, they remain not yet widely exploited or ubiquitous. Recently, a fundamental transformation has occurred in the preparation of LPHNPs, characterized by a transition from a two-step to a one-step strategy, involving synchronous self-assembly of polymers and lipids. Owing to its two-in-one structure, this approach is of particular interest as a combinatorial drug delivery platform in oncology. In particular, the outer surface can be decorated in multifarious ways for active targeting of anticancer therapy, delivery of DNA or RNA materials, and use as a diagnostic imaging agent. This review will provide an update on recent key advancements in design, synthesis, and bioactivity evaluation as well as discussion of future clinical possibilities of LPHNPs. Keywords: lipid–polymer hybrid nanoparticle, lipid-based nanoparticle, polymer-based nanoparticles, drug delivery, gene deliveryhttps://www.dovepress.com/lipid-polymer-hybrid-nanoparticles-as-a-next-generation-drug-delivery--peer-reviewed-article-IJNLipid Polymer Hybrid NanopartcleLipid Based NanoparticlePolymer Based NanopartclesDrug DeliveryGene Delivery |
| spellingShingle | Mukherjee A Waters AK Kalyan P Achrol AS Kesari S Yenugonda VM Lipid–polymer hybrid nanoparticles as a next-generation drug delivery platform: state of the art, emerging technologies, and perspectives International Journal of Nanomedicine Lipid Polymer Hybrid Nanopartcle Lipid Based Nanoparticle Polymer Based Nanopartcles Drug Delivery Gene Delivery |
| title | Lipid–polymer hybrid nanoparticles as a next-generation drug delivery platform: state of the art, emerging technologies, and perspectives |
| title_full | Lipid–polymer hybrid nanoparticles as a next-generation drug delivery platform: state of the art, emerging technologies, and perspectives |
| title_fullStr | Lipid–polymer hybrid nanoparticles as a next-generation drug delivery platform: state of the art, emerging technologies, and perspectives |
| title_full_unstemmed | Lipid–polymer hybrid nanoparticles as a next-generation drug delivery platform: state of the art, emerging technologies, and perspectives |
| title_short | Lipid–polymer hybrid nanoparticles as a next-generation drug delivery platform: state of the art, emerging technologies, and perspectives |
| title_sort | lipid ndash polymer hybrid nanoparticles as a next generation drug delivery platform state of the art emerging technologies and perspectives |
| topic | Lipid Polymer Hybrid Nanopartcle Lipid Based Nanoparticle Polymer Based Nanopartcles Drug Delivery Gene Delivery |
| url | https://www.dovepress.com/lipid-polymer-hybrid-nanoparticles-as-a-next-generation-drug-delivery--peer-reviewed-article-IJN |
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