Preserving inhibition with a disinhibitory microcircuit in the retina
Previously, we found that in the mammalian retina, inhibitory inputs onto starburst amacrine cells (SACs) are required for robust direction selectivity of On-Off direction-selective ganglion cells (On-Off DSGCs) against noisy backgrounds (Chen et al., 2016). However, the source of the inhibitory inp...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2020-12-01
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| Series: | eLife |
| Subjects: | |
| Online Access: | https://elifesciences.org/articles/62618 |
| _version_ | 1818019333955125248 |
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| author | Qiang Chen Robert G Smith Xiaolin Huang Wei Wei |
| author_facet | Qiang Chen Robert G Smith Xiaolin Huang Wei Wei |
| author_sort | Qiang Chen |
| collection | DOAJ |
| description | Previously, we found that in the mammalian retina, inhibitory inputs onto starburst amacrine cells (SACs) are required for robust direction selectivity of On-Off direction-selective ganglion cells (On-Off DSGCs) against noisy backgrounds (Chen et al., 2016). However, the source of the inhibitory inputs to SACs and how this inhibition confers noise resilience of DSGCs are unknown. Here, we show that when visual noise is present in the background, the motion-evoked inhibition to an On-Off DSGC is preserved by a disinhibitory motif consisting of a serially connected network of neighboring SACs presynaptic to the DSGC. This preservation of inhibition by a disinhibitory motif arises from the interaction between visually evoked network dynamics and short-term synaptic plasticity at the SAC-DSGC synapse. Although the disinhibitory microcircuit is well studied for its disinhibitory function in brain circuits, our results highlight the algorithmic flexibility of this motif beyond disinhibition due to the mutual influence between network and synaptic plasticity mechanisms. |
| first_indexed | 2024-04-14T07:50:55Z |
| format | Article |
| id | doaj.art-81fb7e766fa9491694fa1cd96e3edbf2 |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-14T07:50:55Z |
| publishDate | 2020-12-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-81fb7e766fa9491694fa1cd96e3edbf22022-12-22T02:05:11ZengeLife Sciences Publications LtdeLife2050-084X2020-12-01910.7554/eLife.62618Preserving inhibition with a disinhibitory microcircuit in the retinaQiang Chen0Robert G Smith1https://orcid.org/0000-0001-5703-1324Xiaolin Huang2https://orcid.org/0000-0001-7367-8347Wei Wei3https://orcid.org/0000-0002-7771-5974Committee on Computational Neuroscience, University of Chicago, Chicago, United StatesDepartment of Neuroscience, University of Pennsylvania, Philadelphia, United StatesCommittee on Neurobiology, University of Chicago, Chicago, United StatesCommittee on Computational Neuroscience, University of Chicago, Chicago, United States; Committee on Neurobiology, University of Chicago, Chicago, United States; Department of Neurobiology, the University of Chicago, Chicago, United States; Grossman Institute for Neuroscience, Quantitative Biology and Human Behavior, University of Chicago, Chicago, United StatesPreviously, we found that in the mammalian retina, inhibitory inputs onto starburst amacrine cells (SACs) are required for robust direction selectivity of On-Off direction-selective ganglion cells (On-Off DSGCs) against noisy backgrounds (Chen et al., 2016). However, the source of the inhibitory inputs to SACs and how this inhibition confers noise resilience of DSGCs are unknown. Here, we show that when visual noise is present in the background, the motion-evoked inhibition to an On-Off DSGC is preserved by a disinhibitory motif consisting of a serially connected network of neighboring SACs presynaptic to the DSGC. This preservation of inhibition by a disinhibitory motif arises from the interaction between visually evoked network dynamics and short-term synaptic plasticity at the SAC-DSGC synapse. Although the disinhibitory microcircuit is well studied for its disinhibitory function in brain circuits, our results highlight the algorithmic flexibility of this motif beyond disinhibition due to the mutual influence between network and synaptic plasticity mechanisms.https://elifesciences.org/articles/62618retinadisinhibitiondirection selectivityshort-term synaptic plasticitycenter surround receptive fieldvisual motion |
| spellingShingle | Qiang Chen Robert G Smith Xiaolin Huang Wei Wei Preserving inhibition with a disinhibitory microcircuit in the retina eLife retina disinhibition direction selectivity short-term synaptic plasticity center surround receptive field visual motion |
| title | Preserving inhibition with a disinhibitory microcircuit in the retina |
| title_full | Preserving inhibition with a disinhibitory microcircuit in the retina |
| title_fullStr | Preserving inhibition with a disinhibitory microcircuit in the retina |
| title_full_unstemmed | Preserving inhibition with a disinhibitory microcircuit in the retina |
| title_short | Preserving inhibition with a disinhibitory microcircuit in the retina |
| title_sort | preserving inhibition with a disinhibitory microcircuit in the retina |
| topic | retina disinhibition direction selectivity short-term synaptic plasticity center surround receptive field visual motion |
| url | https://elifesciences.org/articles/62618 |
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